DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9514 and Gld

DIOPT Version :9

Sequence 1:	NP_572981.1	Gene:	CG9514 / 32418	FlyBaseID:	FBgn0030592	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	260/588 - (44%)
Similarity:	361/588 - (61%)	Gaps:	31/588 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 DLFDPENRPFN--VQQVDLAYDFIIIGGGSAGTVLASRLSEIPHWKILLLEAGGHETEISDVPLL 139
            ||.||..|..:  ..:.|..||||:|||||||:|:||||||:|.||:||:||||.|...:.:|.:
  Fly    45 DLEDPCGRASSRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSM 109

  Fly   140 SLYLHKSKMDWKYRTQPQPTACQAMKDKRCCWTRGKVLGGSSVLNTMLYIRGNKRDFDQWADFGN 204
            .|....|.:|::|.|:|:|.||.:..::||.|.|||||||:||||.|:|:|||:.|:|.||..||
  Fly   110 FLNFIGSDIDYRYNTEPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGN 174

  Fly   205 PGWSYEDILPYFRKSEDQRNPYLAR-NKRYHGTGGLWTVQDAPYNTPIGPAFLQAGEEMGYDIVD 268
            |||:|.|:||:|:||||  |..|.. ...||..|||..|...|||.|:..|.|:||||:|:.:.|
  Fly   175 PGWAYNDVLPFFKKSED--NLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHD 237

  Fly   269 VNGEQQTGFGFYQFNMRRGSRSSTAKSFLRPARLRPNLHVALFSHVTKVLTDPHTKRATGVQFIR 333
            :||:..|||...|...|.|.|.|:|::||||||:|.|||:.|.:..||:|..||||...||: :.
  Fly   238 LNGQNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVLGVE-VS 301

  Fly   334 D--GRLQNVYATREVILSAGAIGSPHLMMLSGIGHGEELGRVGIPLVQHLPGVGQNLQDHIAVGG 396
            |  |..:.:...:||:|||||:.|||:::|||:|..:||.:|.:..|.:|||||:||.:|
  Fly   302 DQFGSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNH----- 361

  Fly   397 IAFLIDYPISIVMKRMVNINTALRYAITEDGPLTSSIGL-EAVAFINTKYANASDDWPDMNFMMT 460
            :.:..::.|.......:|..||:.|.:..|| |.|..|: :..|.:.|:||: |.:.||:....
  Fly   362 VTYFTNFFIDDADTAPLNWATAMEYLLFRDG-LMSGTGISDVTAKLATRYAD-SPERPDLQLYF- 423

  Fly   461 SASVMSDGGSQVKTAH-GLTDEFYQEVFGEVNNRDVFGVFPMMLRPKSRGYIKLASKNPLRYPLL 524
                   ||.....|. |...|...      ||.....:||.:|.|:|||:|.|.|.:||..|.:
  Fly   424 -------GGYLASCARTGQVGELLS------NNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRI 475

  Fly   525 YHNYLTHPDDVNVLREGVKAAVAMGETQAMKRFGARYWNKPVPNCKHLTLYTDDYWNCFIRQYTM 589
            ..|||||..||..|.||:|..:.:.:|..:|::|.|.....|..|:.....:|.||.|.:||.|.
  Fly   476 VANYLTHEQDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTG 540

  Fly   590 TIYHMSGTAKMGPPTDPWAVVDPQLRVYGIPGLRVIDASIMPAITNGNIHAPVVMIGEKGADMIK 654
            ...|.:|:.||||..||.|||:.:|||:||.||||:|.||||.:::||.|||.|||.||||.::|
  Fly   541 PENHQAGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLK 605

  Fly   655 QLW 657
            :.|
  Fly   606 RAW 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9514	NP_572981.1	PRK02106	95..679	CDD:235000	254/568 (45%)
		NADB_Rossmann	96..>126	CDD:304358	22/29 (76%)
		NADB_Rossmann	167..391	CDD:304358	115/226 (51%)
		GMC_oxred_C	505..648	CDD:282984	67/142 (47%)
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	29/49 (59%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	250/560 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	10	9.870