DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9514 and Eo

DIOPT Version :9

Sequence 1:	NP_572981.1	Gene:	CG9514 / 32418	FlyBaseID:	FBgn0030592	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_572986.1	Gene:	Eo / 32423	FlyBaseID:	FBgn0030597	Length:	657	Species:	Drosophila melanogaster

Alignment Length:	685	Identity:	209/685 - (30%)
Similarity:	317/685 - (46%)	Gaps:	96/685 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VVVPALGAAAVSVGGLLFKASAASKAAAAAGVAAAGASKLGLAIAGAIKLATAVIGVGKLTILPF 66
            :::|.|         |||.....|.......|.::|   ||:::..::.:|...
  Fly    22 ILLPML---------LLFSGETTSVVTQLFSVDSSG---LGISLMQSVAIALNA----------- 63

  Fly    67 LIAAIAYYNYDLFDPENRPFNVQQVDLAYDFIIIGGGSAGTVLASRLSEIPHWKILLLEAGGHET 131
              :::|..|...:..::.|...:....:||:|::|.||||:::||||||:...|:||||.|....
  Fly    64 --SSLALANNTAWPLQHEPPEDRLEIESYDYIVVGAGSAGSIVASRLSELCQVKVLLLEEGQLPP 126

  Fly   132 EISDVPLLSLYLHKSKMDWKY----RTQPQPTACQAMKDKR-CCWTRGKVLGGSSVLNTMLYIRG 191
            ..|::..|:..||.   |.:|    ...|.|..||||.... |.|..|:::||...:|..::|.|
  Fly   127 LESEIFGLTGALHH---DERYMFLEEAVPNPKCCQAMASMHGCVWWHGRMMGGGGAINGNIFIPG 188

  Fly   192 NKRDFDQWADFGNPGWSYEDILPYFRKSEDQRNP-YLARNKRYHGTGGLWTVQDAPYNTPIGPAF 255
            ::.:|.:|   .:.||.:..:...:.:.:.:.|| ||..||.......|.....|....|.....
  Fly   189 SRENFRRW---NSTGWDWTQVHKTYSRLQQRLNPSYLQPNKLNLKLANLIYSGSAELGVPRMKQP 250

  Fly   256 LQAGEEMGYDIVDVNGEQQTGFGFYQFNMRRGSRSSTAKSFLRPARL--RPNLHVALFSHVTKVL 318
            |.||...||          |.......|.||  |:|:|:.:|...::  |.||.|...:.|.:||
  Fly   251 LIAGATFGY----------THHVPVTVNQRR--RASSARLYLANDQVNRRGNLKVIRGAQVQRVL 303

  Fly   319 TDPHTKRATGVQFIRDGRLQNVYATREVILSAGAIGSPHLMMLSGIGHGEELGRVGIPLVQHLPG 383
            .:....|||||.:..:|.........|||||||.:.|..|::|||||..|||.|..|...|.||
  Fly   304 LNAAGSRATGVIYTLNGVEHTAKTLGEVILSAGTLNSAKLLLLSGIGPREELQRWNITTHQDLP- 367

  Fly   384 VGQNLQDHIAVGGI--AFLI----------------DY-PISIVMKRMVNINTALRYAITEDGPL 429
            ||:|||||    |:  .||:                .| |:||....:.|          :.|||
  Fly   368 VGRNLQDH----GMMPLFLLFGSNCAVNSTRDPTENPYAPVSITQYLLDN----------QKGPL 418

  Fly   430 TSSIGLEAVAFINTKYANASDDWPDMNFMMTSASVMSDGGSQVKTAH-GLTDEFYQEVFGEVNNR 493
            .|  |...:.:||:...::|...||::.:   |..:...||.....: |...|..|.....:...
  Fly   419 AS--GFYMMGYINSSSPSSSRGEPDLHVV---AHTLLPKGSTGSFGYLGFRPELIQAQQDILQKG 478

  Fly   494 DVFGVFPMMLRPKSRGYIKLASKNPLRYPLLYHNYLTHPDDVNVLREGVKAAVAMGETQAMKRFG 558
            |:..:...:|||.|.|.:.|:|||......:.::|....:|...|...|:....:.:|:..:|.|
  Fly   479 DLLQIMGSLLRPLSHGKVSLSSKNSADQAKIENHYGEAVEDQQTLLRYVRYIQKLSKTRPFRRCG 543

  Fly   559 ARYWNKPVPNCKHLTLYTDDYWNCFIRQYTMTIYHMSGTAKMGP-----PTDPWAVVDPQLRVYG 618
            .|.|..|:..|..|...:||||.|:||.:.:..:|..||.:|.|     ..:...|||.:|||:|
  Fly   544 LRLWKPPLHECDTLAADSDDYWLCYIRYFYVGAWHSVGTCRMAPRKGVDSQENGGVVDERLRVHG 608

  Fly   619 IPGLRVIDASIMPAITNGNIHAPVVMIGEKGADMI 653
            :.||||:||||||.:..||.:.|.:|||||||.||
  Fly   609 VKGLRVVDASIMPELPAGNTNGPAMMIGEKGAQMI 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9514	NP_572981.1	PRK02106	95..679	CDD:235000	195/592 (33%)
		NADB_Rossmann	96..>126	CDD:304358	17/29 (59%)
		NADB_Rossmann	167..391	CDD:304358	74/227 (33%)
		GMC_oxred_C	505..648	CDD:282984	54/147 (37%)
Eo	NP_572986.1	BetA	88..649	CDD:225186	195/594 (33%)
		NADB_Rossmann	185..375	CDD:304358	68/205 (33%)
		GMC_oxred_C	490..638	CDD:282984	54/147 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		mtm950
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.970