DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9514 and CG9518

DIOPT Version :9

Sequence 1:	NP_572981.1	Gene:	CG9514 / 32418	FlyBaseID:	FBgn0030592	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	341/694 - (49%)
Similarity:	463/694 - (66%)	Gaps:	32/694 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LAIAGAIKLATAVIGVGKLTILPFLIAAIAYYNYDLFDPENRPFNVQQVDLAYDFIIIGGGSAGT 107
            |.|...||....|:..| |.::|.::|||.||.||..|||:||.:...:...||||::|.||||.
  Fly     6 LFITTVIKSTFGVVTTG-LWLIPLMLAAITYYRYDAVDPESRPLDQLNLYPEYDFIVVGSGSAGA 69

  Fly   108 VLASRLSEIPHWKILLLEAGGHETEISDVPLLSLYLHKSKMDWKYRTQPQPTACQAMKDKRCCWT 172
            |:|:||||:..||:||:|||..|.||||||.|:.||..||:||.|:|:|...||..|::.||.|.
  Fly    70 VVANRLSEVRKWKVLLIEAGPDENEISDVPSLAAYLQLSKLDWAYKTEPSTKACLGMQNNRCNWP 134

  Fly   173 RGKVLGGSSVLNTMLYIRGNKRDFDQWADFGNPGWSYEDILPYFRKSEDQRNPYLARNKRYHGTG 237
            ||:|||||||||.|||:|||:.|:|.||..|||||.|:::|.||:||||.||||||.|| |||.|
  Fly   135 RGRVLGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYDNVLRYFKKSEDNRNPYLANNK-YHGRG 198

  Fly   238 GLWTVQDAPYNTPIGPAFLQAGEEMGYDIVDVNGEQQTGFGFYQFNMRRGSRSSTAKSFLRPARL 302
            ||.|||::|:::|:..||::||.::|||..|:||.:|.||...|..:|||||.||||:||||.|:
  Fly   199 GLLTVQESPWHSPLVAAFVEAGTQLGYDNRDINGAKQAGFMIAQGTIRRGSRCSTAKAFLRPIRM 263

  Fly   303 RPNLHVALFSHVTKVLTDPHTKRATGVQFIRDGRLQNVYATREVILSAGAIGSPHLMMLSGIGHG 367
            |.|.|:::.||||:|:.:|.|.||..|:|::.|::..:.|.||||:|||||.:|.||||||:|..
  Fly   264 RKNFHLSMNSHVTRVIIEPGTMRAQAVEFVKHGKVYRIAARREVIISAGAINTPQLMMLSGLGPR 328

  Fly   368 EELGRVGIPLVQHLPGVGQNLQDHIAVGGIAFLIDYPISIVMKRMVNINTALRYAITEDGPLTSS 432
            :.|.:.||.::|.|| ||:|:|||:.:||:.||:|.|::||..|........:|.:.|.||:|:.
  Fly   329 KHLEKHGIRVLQDLP-VGENMQDHVGMGGLTFLVDKPVAIVQDRFNPTAVTFQYVLRERGPMTTL 392

  Fly   433 IGLEAVAFINTKYANASDDWPDMNFMMTSASVMSDGGSQVKTAHGLTDEFYQEVFGEVNNRDVFG 497
            .|:|.:||::|.|:|.|.||||:.|.|..||:.||.|::||...||.:..||||:..:.|:|.:.
  Fly   393 GGVEGLAFVHTPYSNRSLDWPDIQFHMAPASINSDNGARVKKVLGLKESVYQEVYHPIANKDSWT 457

  Fly   498 VFPMMLRPKSRGYIKLASKNPLRYPLLYHNYLTHPDDVNVLREGVKAAVAMGETQAMKRFGARYW 562
            :.|::|||:|||.:||.|.||..|||:..||...|.|...|.||.|.|:.:.|.|..|:||:|.|
  Fly   458 IMPLLLRPRSRGSVKLRSANPFHYPLINANYFDDPLDAKTLVEGAKIALRVAEAQVFKQFGSRLW 522

  Fly   563 NKPVPNCKHLTLYTDDYWNCFIRQYTMTIYHMSGTAKMGPPTDPWAVVDPQLRVYGIPGLRVIDA 627
            .||:||||.....:|.|..|.:|..:|||||..|||||||..||.|||||:|||||:.|||||||
  Fly   523 RKPLPNCKQHKFLSDAYLECHVRTISMTIYHPCGTAKMGPAWDPEAVVDPRLRVYGVRGLRVIDA 587

  Fly   628 SIMPAITNGNIHAPVVMIGEKGADMIKQLWLT---------------PTTAPVGVQG-------- 669
            ||||.|::||.:|||:||.|||||:||:.|||               |..|...:||
  Fly   588 SIMPTISSGNTNAPVIMIAEKGADLIKEDWLTNPEYKVKRQANRLRDPDPASSNIQGIITLPNNI 652

  Fly   670 -QGPSPRQGHNTSPAPPPRTQWRSKRSLNSTEADTETENSENLD 712
             ||.|    .|.|......:.:.:...:|:...::.: ||.|::
  Fly   653 TQGDS----SNISDRSNMESNFSNSSHINNINFNSNS-NSSNIE 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9514	NP_572981.1	PRK02106	95..679	CDD:235000	315/607 (52%)
		NADB_Rossmann	96..>126	CDD:304358	18/29 (62%)
		NADB_Rossmann	167..391	CDD:304358	127/223 (57%)
		GMC_oxred_C	505..648	CDD:282984	81/142 (57%)
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	303/559 (54%)
		NADB_Rossmann	128..351	CDD:304358	127/224 (57%)
		GMC_oxred_C	465..608	CDD:282984	81/142 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	10	9.970