DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9514 and AgaP_AGAP009541

DIOPT Version :9

Sequence 1:	NP_572981.1	Gene:	CG9514 / 32418	FlyBaseID:	FBgn0030592	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_310150.4	Gene:	AgaP_AGAP009541 / 1271369	VectorBaseID:	AGAP009541	Length:	628	Species:	Anopheles gambiae

Alignment Length:	573	Identity:	205/573 - (35%)
Similarity:	324/573 - (56%)	Gaps:	11/573 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 QVDLAYDFIIIGGGSAGTVLASRLSEIPHWKILLLEAG-GHETEISDVPLLSLYLHKSKMDWKYR 153
            |:...||::|:|.|.||.|||:||||.|...:|:||.| |.....::.|:|...|..|...:.|.
Mosquito    57 QLRKVYDYVIVGAGPAGCVLANRLSEDPSVSVLILELGRGERPAFAEPPMLGPMLMGSDYSFGYE 121

  Fly   154 TQPQPTACQAMKDKRCCWTRGKVLGGSSVLNTMLYIRGNKRDFDQWADFGNPGWSYEDILPYFRK 218
            |:.|...|..:.|::|.||.|:.:||||::|.::|.|||:||||.||..|..|||::|:|||::|
Mosquito   122 TERQKYGCLGLTDRKCSWTHGRGVGGSSIINNIIYTRGNRRDFDNWARAGMEGWSWKDVLPYYKK 186

  Fly   219 SEDQRNPYLARNKRYHGTGGLWTVQDAPYNTPIGPAFLQAGEEMGYDIVDVNGEQQTGFGFYQFN 283
            .|.........|.. ||..|..:|:|.|:.:.:..||:.:..:.||..:|.|.....|..|.|.:
Mosquito   187 IEHANVKDFDENGA-HGKSGRVSVEDCPFRSEVAKAFVASAAQSGYPYLDYNAGDILGVSFLQAH 250

  Fly   284 MRRGSRSSTAKSFLRPARLRPNLHVALFSHVTKVLTDPHTKRATGVQFIRDGRLQNVYATREVIL 348
            .::|.|.:...::|:..|.|||||::..|..|::|.:..||..|||:|.::.|...|.|.|||||
Mosquito   251 SKKGHRVTAGTAYLKDVRHRPNLHISTRSWATQILFNEDTKETTGVRFTKNKRYHTVRARREVIL 315

  Fly   349 SAGAIGSPHLMMLSGIGHGEELGRVGIPLVQHLPGVGQNLQDHIAVGGIAFLI--DYPIS---IV 408
            ||||..:|.|:|.||||....|.:.||.::|.|| ||:.:.:|....|..|.:  ..|..   :.
Mosquito   316 SAGAFETPKLLMNSGIGPAAHLQQHGIRVLQDLP-VGRRVYEHGGAFGPIFTMRNGSPAEQNLLS 379

  Fly   409 MKRMVNINTALRYAITEDGPLTSSIGLEAVAFINTKYANASD-DWPDMNFMMTSASVMSDGGSQV 472
            :::::.::..||:. ...||.||: .:|::.::.:.:|:..| |.||:..|....|:..|....:
Mosquito   380 LEQVLTLDEYLRFR-NGTGPATSN-SIESLLYVKSPFASDPDPDLPDVEVMQACGSMSFDSSFAL 442

  Fly   473 KTAHGLTDEFYQEVFGEVNNRDVFGVFPMMLRPKSRGYIKLASKNPLRYPLLYHNYLTHPDDVNV 537
            :||:.|.:...::.:|.:.....|...||:::..:.|.::|.|:||..:|:.::.|.....||..
Mosquito   443 RTAYRLPEALIRDYYGPLVGVRNFMFLPMLMKTHTVGRVELKSRNPFHHPVFHYQYFEDERDVEA 507

  Fly   538 LREGVKAAVAMGETQAMKRFGARYWNKPVPNCKHLTLYTDDYWNCFIRQYTMTIYHMSGTAKMGP 602
            |...::..:.:.|.:.::|.|...:|:|:|.|:.....:||||.|.:|:.|.|..|...|..|||
Mosquito   508 LVYSIREVLRIAEAEPLQRLGIELYNRPLPGCEEFEFNSDDYWRCHVRRQTATFQHQVSTCSMGP 572

  Fly   603 PTDPWAVVDPQLRVYGIPGLRVIDASIMPAITNGNIHAPVVMIGEKGADMIKQ 655
            ..||.|||||:|||.||..|||.|.||:|...:.:..|...:||||.|||||:
Mosquito   573 VGDPDAVVDPRLRVRGIGRLRVADVSIIPEPPSAHTCAMSYLIGEKAADMIKE 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9514	NP_572981.1	PRK02106	95..679	CDD:235000	204/568 (36%)
		NADB_Rossmann	96..>126	CDD:304358	16/29 (55%)
		NADB_Rossmann	167..391	CDD:304358	90/223 (40%)
		GMC_oxred_C	505..648	CDD:282984	52/142 (37%)
AgaP_AGAP009541	XP_310150.4	PRK02106	62..624	CDD:235000	202/565 (36%)
		NADB_Rossmann	63..>94	CDD:304358	17/30 (57%)
		NADB_Rossmann	128..357	CDD:304358	92/230 (40%)
		GMC_oxred_C	476..619	CDD:282984	53/142 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
TreeFam	0	0.000	Not matched by this tool.
	6	5.830