Protein Alignment CG9518 and CHDH

DIOPT Version :9

• Sequence 1: NP_001285249.1
• Gene: CG9518 / 32416
• FlyBaseID: FBgn0030590
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_060867.2
• Gene: CHDH / 55349
• HGNCID: 24288
• Length: 594
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 229/593 - (38%)
• Similarity: 318/593 - (53%)
• Gaps: 56/593 - (9%)

  Fly    56 EYDFIVVGSGSAGAVVANRLSEVRKWKVLLIEAGPDEN---------EISDVPSLAAYLQLSKLD 111
            ||.::|||:||||.|:|.||:|....:|||:||||.:.         :|....:|.|.|...:.:
Human    40 EYSYVVVGAGSAGCVLAGRLTEDPAERVLLLEAGPKDVLAGSKRLSWKIHMPAALVANLCDDRYN 104

  Fly   112 WAYKTEPSTKACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYDNVLR 176
            |.|.||...    |:......||||||.||||.||.|:||||:..||:.|...|..||||.:.|.
Human   105 WCYHTEVQR----GLDGRVLYWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLP 165

  Fly   177 YFKKSEDNRNPYLANNKYHGRGGLLTVQESPWHSPLVAAFVEAGTQLGYD-NRDINGAKQAGFMI 240
            ||:|::.:.   |..::|.|..|.|.|.....:.||..||:||..|.||. ..|:||.:|.||..
Human   166 YFRKAQGHE---LGASRYRGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGW 227

  Fly   241 AQGTIRRGSRCSTAKAFLRPIRMRKNFHLSMNSHVTRVIIEPGTMRAQAVEFVKHGKVYRIAARR 305
            ...||..|.|.|.|.|:|.|...|.|......:.|:||:.| || ||..||:||:|:.:|..|.:
Human   228 MDMTIHEGKRWSAACAYLHPALSRTNLKAEAETLVSRVLFE-GT-RAVGVEYVKNGQSHRAYASK 290

  Fly   306 EVIISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLP-VGENMQDHVGMGGLTFLVDKPVAI-- 367
            |||:|.||||:|||:||||:|....|:|.||.|:..|| ||:|:|||:.: .:.....:|:.:
Human   291 EVILSGGAINSPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEI-YIQQACTRPITLHS 354

  Fly   368 VQDRFNPTAVTFQYVLRERGPMTTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPASINSDNGARV 432
            .|.......:..:::.:..|...| ..:|...|:.   |...:..||||||..|:.: .|:| ||
Human   355 AQKPLRKVCIGLEWLWKFTGEGAT-AHLETGGFIR---SQPGVPHPDIQFHFLPSQV-IDHG-RV 413

  Fly   433 KKVLGLKESVYQEVYHPIANKDSWTIMPLLLRPRSRGSVKLRSANPFHYPLINANYFDDPLDAKT 497
            .    .::..||....|             :|..|.|.:|||||||..:|:|..||    |..:|
Human   414 P----TQQEAYQVHVGP-------------MRGTSVGWLKLRSANPQDHPVIQPNY----LSTET 457

  Fly   498 LVEGAKIALRVAEAQVFKQFGSRLWRKPLPNCKQHKFLSDAYLECHVRTISMTIYHPCGTAKMGP 562
            .:|..::.:::.. ::|.|.....:|........| ..||..::..||..:.:.|||..|.|||.
Human   458 DIEDFRLCVKLTR-EIFAQEALAPFRGKELQPGSH-IQSDKEIDAFVRAKADSAYHPSCTCKMGQ 520

  Fly   563 AWDPEAVVDPRLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEKGADLIKED---WLTN-PEY 623
            ..||.|||||:.||.||..|||:||||||::.|||.|||.||||||.||:||..   |..: |.|
Human   521 PSDPTAVVDPQTRVLGVENLRVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALWDKDVPVY 585

  Fly   624 KVKRQANR 631
            |.:..|.:
Human   586 KPRTLATQ 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	222/570 (39%)
		NADB_Rossmann	128..351	CDD:304358	103/224 (46%)
		GMC_oxred_C	465..608	CDD:282984	61/142 (43%)
CHDH	NP_060867.2	PRK02106	40..594	CDD:235000	229/593 (39%)
		NADB_Rossmann	44..>149	CDD:304358	47/108 (44%)
		NADB_Rossmann	116..339	CDD:304358	105/227 (46%)
		GMC_oxred_C	430..567	CDD:282984	62/142 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2506
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2510
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm40396
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870