DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9518 and CG6142

DIOPT Version :9

Sequence 1:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_651466.1	Gene:	CG6142 / 43178	FlyBaseID:	FBgn0039415	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	609	Identity:	272/609 - (44%)
Similarity:	399/609 - (65%)	Gaps:	14/609 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GVVTTGLWLIPLMLAAITYYR--------YDAVDPESRPLDQLNLYPEYDFIVVGSGSAGAVVAN 73
            ||:...||.|     .:|:.:        ::.....:|..|.....||||||:||:||||.|:||
  Fly     5 GVLIICLWYI-----QVTWSQLLVDLARDFETSFLNNRIPDTTRFLPEYDFIIVGAGSAGCVMAN 64

  Fly    74 RLSEVRKWKVLLIEAGPDENEISDVPSLAAYLQLSKLDWAYKTEPSTKACLGMQNNRCNWPRGRV 138
            ||||:....|||:|||..|..|||||..||..|:::.:|.||.||:..||.|::...||||:||.
  Fly    65 RLSEISSASVLLLEAGDQETFISDVPLTAALTQMTRYNWGYKAEPTEHACQGLKGGVCNWPKGRG 129

  Fly   139 LGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYDNVLRYFKKSEDNRNPYLANNKYHGRGGLLTV 203
            :||:|::|:|||.||:|.|||.||:..|.||.||.:|.||:|||....|.|..:.||||.|.|.|
  Fly   130 VGGTSLINFMLYTRGHRRDYDEWAAANNSGWSYDELLPYFRKSERIGIPELYKSPYHGRNGQLDV 194

  Fly   204 QESPWHSPLVAAFVEAGTQLGYDNRDINGAKQAGFMIAQGTIRRGSRCSTAKAFLRPIRMRKNFH 268
            |.:.:.|.|:.||:::|.::||:..|.||....||..:|.|||.|.||||:|||::|:..|||.|
  Fly   195 QYTDYRSQLLKAFLKSGREMGYEITDPNGEHLMGFARSQATIRNGRRCSTSKAFIQPVVNRKNLH 259

  Fly   269 LSMNSHVTRVIIEPGTMRAQAVEFVKHGKVYRIAARREVIISAGAINTPQLMMLSGLGPRKHLEK 333
            :||.|.|||:||:|.|..|..|||||..:.|.:.||:|||:|||.|.:|||:||||:||.:||.:
  Fly   260 ISMKSWVTRLIIDPITKTATGVEFVKQRQRYVVRARKEVILSAGTIASPQLLMLSGIGPAEHLRE 324

  Fly   334 HGIRVLQDLPVGENMQDHVGMGGLTFLVDKPVAIVQDRFNPTAVTFQYVLRERGPMTTLGGVEGL 398
            |.|.|:||||||.|:|||:.:.||.|:|:..........||:.: |:|:...:||.|..||.|..
  Fly   325 HNITVMQDLPVGYNLQDHITLNGLVFVVNDSTVNDARLLNPSDI-FRYIFAGQGPYTIPGGAEAF 388

  Fly   399 AFVHTPYSNRSLDWPDIQFHMAPASINSDNGARVKKVLGLKESVYQEVYHPIANKDSWTIMPLLL 463
            |||.||.|..:.|:||::..:...|::.|....::.:||:.:..|..::..:.:|:::.::|:||
  Fly   389 AFVRTPSSKFAKDYPDMELVLGAGSLSGDRFGTMRNLLGITDEFYDYMFGDLQSKETFGLVPVLL 453

  Fly   464 RPRSRGSVKLRSANPFHYPLINANYFDDPLDAKTLVEGAKIALRVAEAQVFKQFGSRLWRKPLPN 528
            ||:|||.:.|||.||||:|.:..|:...|.|.:.::||.::.|:::.::...:.|:|...:|.|.
  Fly   454 RPKSRGRISLRSRNPFHWPRMEPNFMQHPDDVRAMIEGIEMILKLSRSKPMAKMGTRFHDRPFPG 518

  Fly   529 CKQHKFLSDAYLECHVRTISMTIYHPCGTAKMGPAWDPEAVVDPRLRVYGVRGLRVIDASIMPTI 593
            |:..||.|:||.:|.:|....::.|..||.|||||.|..:|||.:||::|:|||||:|||::|.:
  Fly   519 CENLKFASEAYWKCCLRRYGSSLQHQSGTCKMGPATDNTSVVDAQLRIHGIRGLRVVDASVLPNV 583

  Fly   594 SSGNTNAPVIMIAEKGADLIKEDW 617
            .:|:|||.|||:|||..|:||:.|
  Fly   584 PAGHTNAIVIMVAEKAGDMIKDAW 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	260/557 (47%)
		NADB_Rossmann	128..351	CDD:304358	119/222 (54%)
		GMC_oxred_C	465..608	CDD:282984	62/142 (44%)
CG6142	NP_651466.1	PRK02106	47..604	CDD:235000	260/557 (47%)
		NADB_Rossmann	48..342	CDD:304358	159/293 (54%)
		GMC_oxred_C	455..599	CDD:282984	63/143 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	8	8.060