DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9518 and Gld

DIOPT Version :9

Sequence 1:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	263/583 - (45%)
Similarity:	358/583 - (61%)	Gaps:	23/583 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DAVDPESRPLDQLNLYP--EYDFIVVGSGSAGAVVANRLSEVRKWKVLLIEAGPDENEISDVPSL 101
            |..||..|...:....|  ||||||:|.||||:|||:|||||.:|||||||||.||...:.:||:
  Fly    45 DLEDPCGRASSRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSM 109

  Fly   102 AAYLQLSKLDWAYKTEPSTKACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGN 166
            ......|.:|:.|.|||...|||.....||.||||:||||:||||.|:||||||.|||.||:.||
  Fly   110 FLNFIGSDIDYRYNTEPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGN 174

  Fly   167 PGWDYDNVLRYFKKSEDNRNPYLANNKYHGRGGLLTVQESPWHSPLVAAFVEAGTQLGYDNRDIN 231
            |||.|::||.:|||||||.:......:||.:||||.|.:.|::.||..|.::||.:||:...|:|
  Fly   175 PGWAYNDVLPFFKKSEDNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHDLN 239

  Fly   232 GAKQAGFMIAQGTIRRGSRCSTAKAFLRPIRMRKNFHLSMNSHVTRVIIEPGTMRAQAVEFV-KH 295
            |....||||||.|.|.|.|.|:|:|||||.|||.|.|:.:|:..|:::|.|.|.....||.. :.
  Fly   240 GQNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVLGVEVSDQF 304

  Fly   296 GKVYRIAARREVIISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLP-VGENMQDHVGMGGLTF 359
            |...:|..::||::||||:|:|.:::|||:||:..|::..:|.:.:|| ||:|:.:||......|
  Fly   305 GSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNFF 369

  Fly   360 LVDKPVAIVQDRFNPTAVTFQYVLRERGPMTTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPASI 424
            :.|...|.:.     .|...:|:|...|.|:..|..:..|.:.|.|:: |.:.||:|.:......
  Fly   370 IDDADTAPLN-----WATAMEYLLFRDGLMSGTGISDVTAKLATRYAD-SPERPDLQLYFGGYLA 428

  Fly   425 NSDNGARVKKVLGLKESVYQEVYHPIANKDSWTIMPLLLRPRSRGSVKLRSANPFHYPLINANYF 489
            :.....:|.::|.             .|..|..|.|.:|.|||||.:.||||:|...|.|.|||.
  Fly   429 SCARTGQVGELLS-------------NNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYL 480

  Fly   490 DDPLDAKTLVEGAKIALRVAEAQVFKQFGSRLWRKPLPNCKQHKFLSDAYLECHVRTISMTIYHP 554
            ....|.||||||.|..:|:::....||:|.||.:..:..|:.|.|.||||.||.||..:....|.
  Fly   481 THEQDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTGPENHQ 545

  Fly   555 CGTAKMGPAWDPEAVVDPRLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEKGADLIKEDW 617
            .|:.||||:.||.|||:..|||:|:|||||:|.||||.:|||||:||.:|||||||.|:|..|
  Fly   546 AGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAW 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	256/559 (46%)
		NADB_Rossmann	128..351	CDD:304358	110/224 (49%)
		GMC_oxred_C	465..608	CDD:282984	75/142 (53%)
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	29/49 (59%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	253/555 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.960