DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9518 and CG9512

DIOPT Version :9

Sequence 1:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_001285253.1	Gene:	CG9512 / 32419	FlyBaseID:	FBgn0030593	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	225/582 - (38%)
Similarity:	330/582 - (56%)	Gaps:	41/582 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 EYDFIVVGSGSAGAVVANRLSEVRKWKVLLIEAGPDENEISDVPSLAAYLQLSKLDWAYKTEPST 120
            :|||||:|||::|||||.||:||:.|||||:|||.|....::..:.....|.|:.||.|.::|:.
  Fly    57 DYDFIVIGSGTSGAVVAGRLAEVKNWKVLLLEAGGDPPIETEFVAWHMATQFSEWDWQYHSKPNG 121

  Fly   121 KACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYDNVLRYFKKSED-- 183
            :||:.|:...|:||||::|||::.:|.|:|.||.|.|:|.|...|||||.||.||::|:|:||
  Fly   122 RACMAMKGESCHWPRGKMLGGTNGMNAMIYARGTRKDFDDWEERGNPGWGYDEVLKHFRKAEDLR 186

  Fly   184 -NRNPYLANNKYHGRGGLL----TVQESPWHSPLVAAFVEAGTQ-LGYDNR-DINGAKQAGFMIA 241
             .|..|...:  ||.||.:    .|.::.:.:.     :.||.| :||.:. |.......|.|..
  Fly   187 STRPDYKPGD--HGVGGPMGLNNYVSDNEFRTT-----IRAGMQEMGYGSAPDFTEGSFVGQMDI 244

  Fly   242 QGTIRRGSRCSTAKAFLRPIRMRKNFHLSMNSHVTRVIIEPGTMRAQAVEFVKHG-KVYRIAARR 305
            .||...|.|.:||::.|:  :...|.|:..::||.::.::... ||::|.||..| |.|.:.|.:
  Fly   245 LGTQDGGRRITTARSHLK--KNTPNLHILRHAHVKKINLDRNN-RAESVTFVHRGKKEYTVKASK 306

  Fly   306 EVIISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLPVGENMQDHVGMGGLTFLVDKPVA---- 366
            |||:|||||.:||:::|||:||..||:..||.|..|||||||::||..: .:.|.:||..|
  Fly   307 EVIVSAGAIGSPQILLLSGIGPADHLKSLGIPVKLDLPVGENLKDHASL-PMIFQIDKSTARKPT 370

  Fly   367 ---IVQDRFNPTAVTFQYVLRERGPMTTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPASINSDN 428
               :|...:|.....:..:|....  |.|.|......:..|.       ||||.....:.:.|..
  Fly   371 EEELVDAMYNLLMGRYSKLLHHEA--TALTGFINTTSIEGPN-------PDIQTTNFFSLMQSPE 426

  Fly   429 GARVKKVLGLKESVYQEVYHPIANKDSWTIMPLL--LRPRSRGSVKLRSANPFHYPLINANYFDD 491
            ........|..:.|.:.:..  ||:::.|.:..|  |:|.|.||:.|:|||....|:|:..|..|
  Fly   427 LKGYVAATGFNDRVAKSILS--ANQETNTYITYLLHLKPFSAGSLTLQSANYLDAPIIDPGYMTD 489

  Fly   492 PLDAKTLVEGAKIALRVAEAQVFKQFGSRLWRKPLPNCKQHKFLSDAYLECHVRTISMTIYHPCG 556
            ..|..|.:....|...:...:.|.:..:.|.:..|..|....:.||.|..|::|.::.|:|||.|
  Fly   490 ERDVDTYIRALNIYKNLPNTKAFSEREAALHKLDLEACNGLTYQSDDYWRCYIRHMTTTVYHPVG 554

  Fly   557 TAKMGPAWDPEAVVDPRLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEKGADLIKEDWL 618
            |.:|||:.||.|||||:|||:|.:|||||||||||.|...||||..|||||||||:|||::|
  Fly   555 TTRMGPSTDPTAVVDPQLRVHGAKGLRVIDASIMPDIVGANTNAACIMIAEKGADMIKEEYL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	221/576 (38%)
		NADB_Rossmann	128..351	CDD:304358	92/232 (40%)
		GMC_oxred_C	465..608	CDD:282984	64/142 (45%)
CG9512	NP_001285253.1	PRK02106	56..612	CDD:235000	221/576 (38%)
		NADB_Rossmann	120..352	CDD:304358	95/241 (39%)
		GMC_oxred_C	463..606	CDD:282984	64/142 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446455
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	10	9.890