DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9518 and AgaP_AGAP002551

DIOPT Version :9

Sequence 1:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	XP_312388.4	Gene:	AgaP_AGAP002551 / 1273414	VectorBaseID:	AGAP002551	Length:	622	Species:	Anopheles gambiae

Alignment Length:	579	Identity:	253/579 - (43%)
Similarity:	366/579 - (63%)	Gaps:	19/579 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PESRPLDQLNLYPEYDFIVVGSGSAGAVVANRLSEVRKWKVLLIEAGPDENEISDVPSLAAYLQL 107
            ||::     .:..||||:|:|:||.|:|:||||||||.|.|||:|.|.:||.||:||..|.....
Mosquito    54 PEAK-----RIRDEYDFVVIGAGSGGSVMANRLSEVRDWSVLLLEVGKEENLISNVPLTAGLTTA 113

  Fly   108 SKLDWAYKTEPSTKACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYD 172
            :...|.|:::|...||.|::...|.||:||.|||:|::|::||.||::.|||.|...||.||.|.
Mosquito   114 TGYSWGYRSDPMRNACRGLEQGVCYWPKGRGLGGTSLINFLLYGRGHQRDYDDWERAGNYGWGYR 178

  Fly   173 NVLRYFKKSEDNR----NPYLANNKYHGRGGLLTVQESPWHSPLVAAFVEAGTQLGYDNRDINGA 233
            :|.|||:|:|..:    ||:          |.|.::||.:.:|::..::|||.:.||.:.|.|..
Mosquito   179 DVRRYFEKAEQIKGQPYNPH----------GYLHIEESSFETPMLGRYIEAGKRFGYRHIDPNDP 233

  Fly   234 KQAGFMIAQGTIRRGSRCSTAKAFLRPIRMRKNFHLSMNSHVTRVIIEPGTMRAQAVEFVKHGKV 298
            .|.||..||.|:..|.|||.|:|:|:|:..|.|..:|..|..||::|:|.|..|..|||.|:.::
Mosquito   234 VQLGFYKAQATMVNGERCSAARAYLKPVADRPNLDISTRSWATRILIDPVTKTAFGVEFTKNKRL 298

  Fly   299 YRIAARREVIISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLPVGENMQDHVGMGGLTFLVDK 363
            :.:..|:|||::||||.:|||:||||:|||:||::..|.|::||.||.|:|||..:.||.|.|::
Mosquito   299 HTVRVRKEVILAAGAIASPQLLMLSGVGPREHLQQLDIPVVKDLRVGYNLQDHQTLSGLVFTVNQ 363

  Fly   364 PVAIVQDRFNPTAVTFQYVLRERGPMTTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPASINSDN 428
            ||.|.:......|....|:...|||.|..||.||:|||.|..|....|:||::..:...::|:|.
Mosquito   364 PVTIRERDMRRPAPFLSYLFARRGPFTVPGGAEGIAFVKTNNSRSPEDYPDVELVLGTGAVNNDE 428

  Fly   429 GARVKKVLGLKESVYQEVYHPIANKDSWTIMPLLLRPRSRGSVKLRSANPFHYPLINANYFDDPL 493
            ...::...|:....|...:.....:.::.|.|:|:||:|||.|.|:|.||||:|.:..|:||.|.
Mosquito   429 SGSLRHTFGMTREFYDRSFGSARGQHAFGIAPVLMRPKSRGRVWLKSRNPFHWPHMEGNFFDHPD 493

  Fly   494 DAKTLVEGAKIALRVAEAQVFKQFGSRLWRKPLPNCKQHKFLSDAYLECHVRTISMTIYHPCGTA 558
            |..|:|||.|:|:|:.|:..|..:|:||...|...|:.|.|.||.|..|.:|.:..:|.|..||.
Mosquito   494 DLATMVEGIKLAVRIGESDSFASYGARLLGTPFYGCEAHPFRSDDYWRCCLRQVGASIQHQSGTC 558

  Fly   559 KMGPAWDPEAVVDPRLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEKGADLIKEDW 617
            |||||.||:|||||.|||:||.||||:||||.|.|.:.:||..|||:.||.||::|:.|
Mosquito   559 KMGPASDPDAVVDPELRVHGVGGLRVVDASIFPVIPAAHTNGVVIMVGEKAADMVKDYW 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	249/561 (44%)
		NADB_Rossmann	128..351	CDD:304358	99/226 (44%)
		GMC_oxred_C	465..608	CDD:282984	74/142 (52%)
AgaP_AGAP002551	XP_312388.4	PRK02106	62..614	CDD:235000	249/561 (44%)
		NADB_Rossmann	137..351	CDD:304358	99/223 (44%)
		GMC_oxred_C	465..609	CDD:282984	75/143 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
TreeFam	0	0.000	Not matched by this tool.
	5	4.920