DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9518 and AgaP_AGAP003786

DIOPT Version :9

Sequence 1:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	XP_310337.6	Gene:	AgaP_AGAP003786 / 1271523	VectorBaseID:	AGAP003786	Length:	665	Species:	Anopheles gambiae

Alignment Length:	607	Identity:	283/607 - (46%)
Similarity:	373/607 - (61%)	Gaps:	24/607 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LIPLML-AAITYYRYDAVDPESRPLD--QLNLYPEYDFIVVGSGSAGAVVANRLSEVRKWKVLLI 86
            ||.|:| |.|...|.|.||..:|..|  ...:|..|||:|:|.|||||..|.|||||..|.|||:
Mosquito    24 LILLILDACIWLQRTDVVDYRNRVQDIPSQFIYDVYDFVVIGGGSAGAAAAARLSEVCDWNVLLL 88

  Fly    87 EAGPDENEISDVPSLAAYLQLSKLDWAYKTEPSTKACLGMQNNRCNWPRGRVLGGSSVLNYMLYV 151
            |||.||:.:||:|.|...||...|||.::|||:.:.|.||:.|||:||||:|||||||||.|:||
Mosquito    89 EAGTDESFLSDLPYLYPALQKGPLDWQFETEPNERFCQGMRGNRCSWPRGKVLGGSSVLNAMMYV 153

  Fly   152 RGNRHDYDHWASLGNPGWDYDNVLRYFKKSEDNRNPYLANNKYHGRGGLLTVQESPWHSPLVAAF 216
            ||:..|||.||..||.||.:.:||.||.|.|:.|:|.:|...|||..|.:||:.....|.|...|
Mosquito   154 RGHPEDYDEWARFGNRGWSWQDVLPYFVKMENVRDPNIAGRPYHGTTGPMTVELIRNRSALQPMF 218

  Fly   217 VEAGTQLGYDNRD-INGAKQAGFMIAQGTIRRGSRCSTAKAFLRPIRMRKNFHLSMNSHVTRVII 280
            ::|..:||....| :||..|..|....|:||.|.|||||||:||||..|||.|:||||.|.|::|
Mosquito   219 LQAAQELGMKLADEVNGPDQLVFAPLHGSIRDGLRCSTAKAYLRPIGNRKNLHISMNSMVERILI 283

  Fly   281 EPGTMRAQAVEFVKHGKVYRIAARREVIISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLP-V 344
            :|...||..|.|.|..:...:...:|:::||||:|:|.|:||||:|||..|::|||||:.:|| |
Mosquito   284 DPKDRRAYGVVFRKGNRRQFVLVTKEIVLSAGALNSPHLLMLSGVGPRDQLQRHGIRVIHELPGV 348

  Fly   345 GENMQDHVGMGGLTFLVDKP-------VAIVQDRFNPTAVTFQYVLRERGPMTTLGGVEGLAFVH 402
            |:|:||||..||..||:..|       :.:|:  .|..:|...::.|.:|.:.::...|.:.|::
Mosquito   349 GQNLQDHVAAGGGVFLIQNPTGSAPLSIRLVE--VNEVSVARDFLFRNQGRLLSMPSCEVMGFIN 411

  Fly   403 TPYSNRSLDWPDIQFHMAPASINSDNGARVKKVLGLKESVYQE-----VYHPIANKDSWTIMPLL 462
            |.|:.......|:|..|:..|..||.|...:...||....|..     |||     ||:.|||||
Mosquito   412 TKYNKPGSRRGDVQIFMSAQSDISDGGTEGQAGAGLTYEYYARNFESWVYH-----DSFLIMPLL 471

  Fly   463 LRPRSRGSVKLRSANPFHYPLINANYFDDPLDAKTLVEGAKIALRVAEAQVFKQFGSRLWRKPLP 527
            :.|.|||.::|.||||.....|..|||....|...||||.|..:||||..|.::..:........
Mosquito   472 MHPESRGWLELPSANPMDKIKIYPNYFAVERDLDILVEGLKFGVRVAETSVMRKINATFIYDAEH 536

  Fly   528 NCKQHKFLSDAYLECHVRTISMTIYHPCGTAKMGPAWDPEAVVDPRLRVYGVRGLRVIDASIMPT 592
            ....:..:.||:.:|.::..|.|||||.||||||||.||.||||.:|||:|:.||||:||||||.
Mosquito   537 GDTCNGQVGDAFFKCLIQHYSQTIYHPSGTAKMGPATDPMAVVDDQLRVHGIGGLRVVDASIMPK 601

  Fly   593 ISSGNTNAPVIMIAEKGADLIK 614
            |::||||||.|||||:.|||||
Mosquito   602 ITTGNTNAPTIMIAERAADLIK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	268/571 (47%)
		NADB_Rossmann	128..351	CDD:304358	115/224 (51%)
		GMC_oxred_C	465..608	CDD:282984	72/142 (51%)
AgaP_AGAP003786	XP_310337.6	PRK02106	59..634	CDD:235000	270/572 (47%)
		NADB_Rossmann	130..357	CDD:304358	117/226 (52%)
		GMC_oxred_C	474..618	CDD:282984	73/143 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
TreeFam	0	0.000	Not matched by this tool.
	5	4.920