DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9518 and AgaP_AGAP003783

DIOPT Version :9

Sequence 1:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	XP_003436611.1	Gene:	AgaP_AGAP003783 / 1271522	VectorBaseID:	AGAP003783	Length:	695	Species:	Anopheles gambiae

Alignment Length:	573	Identity:	353/573 - (61%)
Similarity:	438/573 - (76%)	Gaps:	4/573 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PLDQLNLYPEYDFIVVGSGSAGAVVANRLSEVRKWKVLLIEAGPDENEISDVPSLAAYLQLSKLD 111
            |...|:|...|||:|:|:||||||||:||||:..|.|||:|||.||||::||||||.||||::.|
Mosquito   119 PKQDLDLRRYYDFVVIGAGSAGAVVASRLSEIGDWSVLLLEAGGDENEVTDVPSLAGYLQLTEYD 183

  Fly   112 WAYKTEPST--KACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYDNV 174
            |.|:|.||.  :.|..|..:|||||||:|:|||||||.|:||||||.|||.|...||.||.|:||
Mosquito   184 WKYQTTPSADRRYCQAMIGDRCNWPRGKVMGGSSVLNAMVYVRGNRLDYDQWQEQGNVGWGYENV 248

  Fly   175 LRYFKKSEDNRNPYLANNKYHGRGGLLTVQESPWHSPLVAAFVEAGTQLGYDNRDINGAKQAGFM 239
            |.||.|||||||||:|.:.|||.||.|||||:||.:||..|||.||.::||:|||||||:|.|||
Mosquito   249 LPYFIKSEDNRNPYMARSPYHGVGGYLTVQEAPWRTPLSVAFVAAGQEMGYENRDINGAEQTGFM 313

  Fly   240 IAQGTIRRGSRCSTAKAFLRPIRMRKNFHLSMNSHVTRVIIEPGTMRAQAVEFVKHGKVYRIAAR 304
            :.|.||||||||||:||||||:|:|||.|::||:||||::.: ...||..||||:|.|...:.||
Mosquito   314 LLQATIRRGSRCSTSKAFLRPVRLRKNLHIAMNAHVTRILFD-DQHRAYGVEFVRHQKRQYVFAR 377

  Fly   305 REVIISAGAINTPQLMMLSGLGPRKHLEKHGIRVLQDLPVGENMQDHVGMGGLTFLVDKPVAIVQ 369
            :|:|:||||:||||::||||:||..||::.||.|:.|||||:|:|||||:||||||||:||.:..
Mosquito   378 KEIILSAGALNTPQILMLSGVGPADHLDELGIPVVSDLPVGDNLQDHVGLGGLTFLVDQPVTVKT 442

  Fly   370 DRFNPTAVTFQYVLRERGPMTTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPASINSDNGARVKK 434
            .|::...|..:|.|.||||| |..|:||:|||:|.|::.|..|||||||..|:|:|||.|..::|
Mosquito   443 SRYSSVPVALEYFLNERGPM-TFPGIEGVAFVNTKYADPSGKWPDIQFHFGPSSVNSDGGQNIRK 506

  Fly   435 VLGLKESVYQEVYHPIANKDSWTIMPLLLRPRSRGSVKLRSANPFHYPLINANYFDDPLDAKTLV 499
            :|.|::..|..||.||.|.::|||:||||||:|.|.|:|||.|||..|.|..|||....|...||
Mosquito   507 ILNLRDGFYNTVYKPIQNAETWTILPLLLRPKSTGWVRLRSKNPFVQPSIEPNYFAHEEDVAVLV 571

  Fly   500 EGAKIALRVAEAQVFKQFGSRLWRKPLPNCKQHKFLSDAYLECHVRTISMTIYHPCGTAKMGPAW 564
            ||.|||:.|:..|.|::|.||....|||.|:...|:||||..|.::..:.|||||.|||||||:|
Mosquito   572 EGIKIAINVSYTQAFQRFNSRPHAIPLPGCRHLPFMSDAYWACTIKQFTFTIYHPAGTAKMGPSW 636

  Fly   565 DPEAVVDPRLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEKGADLIKEDW 617
            ||.||||||||||||.||||:||||||||.|||.|||||||.||.||:|||||
Mosquito   637 DPGAVVDPRLRVYGVSGLRVVDASIMPTIISGNPNAPVIMIGEKAADMIKEDW 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	345/559 (62%)
		NADB_Rossmann	128..351	CDD:304358	144/222 (65%)
		GMC_oxred_C	465..608	CDD:282984	88/142 (62%)
AgaP_AGAP003783	XP_003436611.1	NADB_Rossmann	117..>151	CDD:304358	20/31 (65%)
		PRK02106	129..686	CDD:235000	345/558 (62%)
		NADB_Rossmann	188..424	CDD:304358	149/236 (63%)
		GMC_oxred_C	537..681	CDD:282984	89/143 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
TreeFam	0	0.000	Not matched by this tool.
	4	4.020