DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9518 and AgaP_AGAP013123

DIOPT Version :9

Sequence 1:	NP_001285249.1	Gene:	CG9518 / 32416	FlyBaseID:	FBgn0030590	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	XP_003436606.1	Gene:	AgaP_AGAP013123 / 11176021	VectorBaseID:	AGAP013123	Length:	528	Species:	Anopheles gambiae

Alignment Length:	575	Identity:	196/575 - (34%)
Similarity:	299/575 - (52%)	Gaps:	69/575 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 YDFIVVGSGSAGAVVANRLSEVRKWKVLLIEA--GPDENEISDVPSLAAYLQLSKLDWAYKTEPS 119
            |||||||.|:||:|:|:||:|:::|.:|||||  ||.:.::|               |..:.:..
Mosquito    19 YDFIVVGGGTAGSVIASRLAELQQWHILLIEAGGGPSDKDLS---------------WNLQAQRQ 68

  Fly   120 TKACLGMQNNRCNWPRGRVLGGSSVLNYMLYVRGNRHDYDHWASLGNPGWDYDNVLRYFKKSED- 183
            ..:|||....||..|.||.|||:::.|.||||||:..|||.||...|..|.|.|||.||.|.|:
Mosquito    69 MGSCLGAPEQRCEIPTGRGLGGNTLTNNMLYVRGSEADYDAWAKQTNVDWSYRNVLPYFLKLENF 133

  Fly   184 NRNPYLANNKYHGRGGLLTVQESPWHSPLVAAFVEAGTQLGYDNRDINGAKQAGFMIAQGTIRRG 248
            .:|....:.:..|:||.:.:......||||.:|:.|..:||....|.|..:.......|.|..|.
Mosquito   134 RKNASSTSRQQRGKGGPVPIAGLREKSPLVRSFISACNRLGLRTTDYNAERNQTVGFVQLTQYRT 198

  Fly   249 SRCSTAKAFLRPIR-MRKNFHLSMNSHVTRVIIEPGTMRAQAVEFVKHGKVYRIAARREVIISAG 312
            .|.:.|.|::||:: :..|.|:..::.||:|:|.....:|..|:.:.:||..::.|.:|||:|||
Mosquito   199 KRITAADAYIRPVKQLFNNLHIMSSARVTKVLINGMNRQAVGVKVLVNGKQRKLRATKEVILSAG 263

  Fly   313 AINTPQLMMLSGLGPRKHLEKHGIRVLQDLPVGENMQDHVGMGGLTFLVDKPVAIVQDRFNPTAV 377
            .|.||.|::|||:|||..|:...|.||.|||||..|.        ..||..|:.:..:|
Mosquito   264 PIFTPHLLLLSGIGPRAQLDALQIPVLADLPVGATMN--------LRLVSFPLHLATNR------ 314

  Fly   378 TFQYVLRERGPMTTLGGVEGLAFVHTPYSNRSLDWPDIQFHMAPASINSDNGARVKKVLGLKESV 442
            |..|..::.        :|.:||::|...|                 |:|         ...|.:
Mosquito   315 TVPYAAQKM--------IEAIAFLNTTKQN-----------------NTD---------PTHEIL 345

  Fly   443 YQEVYHPIANKDSWTIMPLLLRPRSRGSVKLRSANPFHYPLINANYFDDPLDAKTLVEGAKIALR 507
            :|  |.|....:.:::..:.|||.|||.|:|.:.||...|::..|:|..|.|.:.::.|....|:
Mosquito   346 FQ--YEPRGTLEYFSLGLIHLRPASRGFVQLNATNPSRNPVVYTNFFSAPNDMEEILSGITECLK 408

  Fly   508 VAEAQVFKQFGSRLWRKPLPNCKQHKFLSDAYLECHVRTISMTIYHPCGTAKMGPAWDPEAVVDP 572
            :..::.|.:.|.:..:..:|.|.:.::.:|.|..|.||.:......|.||..||...:.:|||.|
Mosquito   409 IVHSEEFTKLGLQSRKLIVPPCDKLRYGTDEYWRCVVRHVGHAADQPYGTCPMGRQDNRQAVVSP 473

  Fly   573 RLRVYGVRGLRVIDASIMPTISSGNTNAPVIMIAEKGADLIKEDWLTNPEYKVKR 627
            .|||:|:..||:.|||:|..:|:|:|.|.|.|||||.:||||..|....|.:.:|
Mosquito   474 ELRVHGIGNLRIADASVMLPVSNGHTQATVYMIAEKASDLIKSSWDWGNELERRR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9518	NP_001285249.1	PRK02106	56..614	CDD:235000	191/560 (34%)
		NADB_Rossmann	128..351	CDD:304358	89/224 (40%)
		GMC_oxred_C	465..608	CDD:282984	51/142 (36%)
AgaP_AGAP013123	XP_003436606.1	NADB_Rossmann	1..>50	CDD:304358	19/30 (63%)
		PRK02106	18..515	CDD:235000	191/560 (34%)
		NADB_Rossmann	19..281	CDD:304358	107/276 (39%)
		GMC_oxred_C	366..510	CDD:282984	52/143 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
TreeFam	0	0.000	Not matched by this tool.
	5	4.920