DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9519 and CHDH

DIOPT Version :9

Sequence 1:	NP_572978.1	Gene:	CG9519 / 32415	FlyBaseID:	FBgn0030589	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_060867.2	Gene:	CHDH / 55349	HGNCID:	24288	Length:	594	Species:	Homo sapiens

Alignment Length:	627	Identity:	219/627 - (34%)
Similarity:	299/627 - (47%)	Gaps:	114/627 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ALMDMLEIYRRGQAQLDLENLDEGQVITTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEAGGP 96
            ||.....:..|..|....|:.||       |.::|||||:|||.||.||:|:|..||||||||..
Human    18 ALGQQQSLGARALASAGSESRDE-------YSYVVVGAGSAGCVLAGRLTEDPAERVLLLEAGPK 75

  Fly    97 ENYA----------MDIPIVAHLLQLGEINWKYKTEPSNSYCLAMNNNRCNWPRGKVMGGSSVLN 151
            :..|          |...:||:|.. ...||.|.||...    .::.....||||:|.||||.||
Human    76 DVLAGSKRLSWKIHMPAALVANLCD-DRYNWCYHTEVQR----GLDGRVLYWPRGRVWGGSSSLN 135

  Fly   152 YMMYTRGNRRDYDRWARLGNPGWSYEEVLPYFKKYEGSVVPDADENLVGRNGPVKVSYSETRTRI 216
            .|:|.||:..||:||.|.|..||.|...||||:|.:|..:  ......|.:||::||..:|...:
Human   136 AMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRKAQGHEL--GASRYRGADGPLRVSRGKTNHPL 198

  Fly   217 ADAFVGATQDAGLP-RGDYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKGKRRNLHVKKNALV 280
            ..||:.|||.||.| ..|.||.:|....::...|:...|||:..|||:|.. .|.||..:...||
Human   199 HCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSAACAYLHPAL-SRTNLKAEAETLV 262

  Fly   281 TKILIDPQTKSAFGIIVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLA 345
            :::|.  :...|.|:....:|:..:..|.||||||.||||:||||||||:|.|..|:::||..:.
Human   263 SRVLF--EGTRAVGVEYVKNGQSHRAYASKEVILSGGAINSPQLLMLSGIGNADDLKKLGIPVVC 325

  Fly   346 DL-AVGYNLQDHIAPAISFLCN---------------VSSLQTSEMFRSEAMSDFLKGRGVLRIP 394
            .| .||.|||||:...|...|.               ...|:....|..|..:..|:..|.:|..
Human   326 HLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLRKVCIGLEWLWKFTGEGATAHLETGGFIRSQ 390

  Fly   395 GGV--EAISFY-----ALDDARNPDAWADMELFVVGGGLQTNLALRLALGIQSNIYETMFGELER 452
            .||  ..|.|:     .:|..|.|                          .|...|:...|
Human   391 PGVPHPDIQFHFLPSQVIDHGRVP--------------------------TQQEAYQVHVG---- 425

  Fly   453 QSANGFLIFPMILRAKSRGRIKLKSRNPEEHPRIYANYFANPYDM---NITVRGIEQAVSLLDMP 514
                     ||  |..|.|.:||:|.||::||.|..||.:...|:   .:.|:...:..:...:.
Human   426 ---------PM--RGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALA 479

  Fly   515 AFKA----IGAHL-LEKRIPNCAKYKWKSSAYWACYARHFTFTIYHYSGTAKMGPRSDPSAVVDA 574
            .|:.    .|:|: .:|.|....:.|..|:              ||.|.|.|||..|||:||||.
Human   480 PFRGKELQPGSHIQSDKEIDAFVRAKADSA--------------YHPSCTCKMGQPSDPTAVVDP 530

  Fly   575 RLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEKAADMIK 616
            :.||.|::.||||||||||.::||:.|.|..:|||||||:||
Human   531 QTRVLGVENLRVVDASIMPSMVSGNLNAPTIMIAEKAADIIK 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9519	NP_572978.1	PRK02106	59..616	CDD:235000	210/598 (35%)
		NADB_Rossmann	63..>99	CDD:304358	22/35 (63%)
		NADB_Rossmann	132..356	CDD:304358	95/225 (42%)
		GMC_oxred_C	468..611	CDD:282984	55/150 (37%)
CHDH	NP_060867.2	PRK02106	40..594	CDD:235000	213/605 (35%)
		NADB_Rossmann	44..>149	CDD:304358	49/109 (45%)
		NADB_Rossmann	116..339	CDD:304358	97/227 (43%)
		GMC_oxred_C	430..567	CDD:282984	55/150 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2506
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2510
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm40396
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780