DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9521 and fiz

DIOPT Version :9

Sequence 1:	NP_572977.1	Gene:	CG9521 / 32414	FlyBaseID:	FBgn0030588	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001285254.1	Gene:	fiz / 32420	FlyBaseID:	FBgn0030594	Length:	646	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	216/582 - (37%)
Similarity:	315/582 - (54%)	Gaps:	41/582 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LDSEYDFIVVGAGTAGCALAARLSENPQWRVLLLEAGGPERLVMDVPIVAHFLQLGEMNWKYRTQ 120
            |...|||:|:|||:||..:|:||||||.||||:|||||...:..::|.:...||.....|.|.|:
  Fly    65 LSQPYDFVVIGAGSAGSVVASRLSENPDWRVLVLEAGGDPPVESELPALFFGLQHTNFTWNYFTE 129

  Fly   121 PSDHACLAMNNNRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWEALGNPGWSFKDVLPYFKKYE 185
            |||.||.||.:.||.|||||::|||..:|.|:|.||||||:|.|.|:|:.|||:..|:|:|:|
  Fly   130 PSDEACQAMKDGRCYWPRGKMLGGSGGVNAMLYVRGNRRDFDGWAAMGSTGWSYDQVMPFFEK-- 192

  Fly   186 GSSVPDAEEDYVGRNGPVKVSYVNWR------SKIAEAFVDAAQQDGLKYRDYNGRIQNG--VAF 242
             |..|..       |......||..:      :.|.:..:|..::.|..|.:   |.|.|  ..:
  Fly   193 -SVTPQG-------NATHPKGYVTLKPFERKDNDIHQMIIDGGRELGQPYVE---RFQEGSDTGY 246

  Fly   243 LHT--TTRNSTRWSSNRAYLYPLKGKRSNLHVRKNALVTKVLIDPQTKTAYGIMVQTEGRMQKIL 305
            .|.  |.|...|.|:.:.||..:...|.||||.|||||||:.:|.:  |...:..:..|...::.
  Fly   247 SHVPGTVRQGQRMSTGKGYLGAVSKSRPNLHVVKNALVTKLDLDGE--TVKEVKFERAGVTHRVK 309

  Fly   306 ARKEVIVSAGAINTPQLLMLSGVGPAKHLREVGIKPLADL-AVGYNLQDHTAPAVTFTTNATSLK 369
            ..|:|::|||||::|.||:.||:||:|||:|:||....|| .||.|||||....|....:..  :
  Fly   310 VTKDVVISAGAIDSPALLLRSGIGPSKHLKELGIPVKLDLPGVGRNLQDHVLVPVFLRLDEG--Q 372

  Fly   370 FEDFSDPTLINRFNR----MEGPYGSPGGCEAIAFWDLDHERDEDG-WPDIE---LFLVGGSMSS 426
            .|..:|...::...:    ..||..:......:.|  ::.....|| :||.|   :|......:|
  Fly   373 GEPMTDQAALDSIYQYLIYRAGPLAAHSTASLVGF--INTNASSDGAYPDTENHHMFFQRAHHAS 435

  Fly   427 NPAISRAFGLKKSIYDTLFAEIEDKSLNAFMIFPMILRPKSRGRIMLKSSDPFKYPLIHANYFAH 491
            ....::...::....:.|...::|..|  ..:|.::..|.:||.:.|||:||...|::.:||...
  Fly   436 LELFTKGLSIQDQYTEVLQEYLKDSHL--LCVFVLLSHPAARGELRLKSTDPKVPPILTSNYLTE 498

  Fly   492 PYDVDISVRGLLKAISLMEQRGMEKINARLWEKKIPTCKQ-HPYKSWAYWACYVRHFTFTIYHYS 555
            ..||...:||:....||.:.:..:...|.:....|..|.| ..|:|..||.||.::||.|.||.|
  Fly   499 SEDVATLMRGIRYIESLEQTKAFQDHLAEIARIPIKECDQIENYRSEEYWRCYAKYFTVTCYHQS 563

  Fly   556 GTAKMGPKSDRAAVVDHRLRVHGIKNLRVADASIMPEIMSGHPNGPVFMIAEKAADMIKQDH 617
            ||.||||..|..|.|..||:|||::|||||||||||.::|.:.|....||.|:||..|::|:
  Fly   564 GTVKMGPDYDNEACVSQRLKVHGLENLRVADASIMPAVVSANTNAATVMIGERAAHFIQEDY 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9521	NP_572977.1	PRK02106	57..614	CDD:235000	213/576 (37%)
		NADB_Rossmann	61..>92	CDD:304358	21/30 (70%)
		NADB_Rossmann	125..356	CDD:304358	97/241 (40%)
		GMC_oxred_C	465..609	CDD:282984	63/144 (44%)
fiz	NP_001285254.1	PRK02106	66..621	CDD:235000	213/575 (37%)
		NADB_Rossmann	70..>105	CDD:304358	24/34 (71%)
		NADB_Rossmann	142..359	CDD:304358	91/231 (39%)
		GMC_oxred_C	472..617	CDD:282984	63/144 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446464
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	11	10.800