DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9521 and CG9512

DIOPT Version :9

Sequence 1:	NP_572977.1	Gene:	CG9521 / 32414	FlyBaseID:	FBgn0030588	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001285253.1	Gene:	CG9512 / 32419	FlyBaseID:	FBgn0030593	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	595	Identity:	213/595 - (35%)
Similarity:	317/595 - (53%)	Gaps:	72/595 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 EYDFIVVGAGTAGCALAARLSENPQWRVLLLEAGGPERLVMDVPIVAHFL------QLGEMNWKY 117
            :|||||:|:||:|..:|.||:|...|:||||||||      |.||...|:      |..|.:|:|
  Fly    57 DYDFIVIGSGTSGAVVAGRLAEVKNWKVLLLEAGG------DPPIETEFVAWHMATQFSEWDWQY 115

  Fly   118 RTQPSDHACLAMNNNRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWEALGNPGWSFKDVLPYFK 182
            .::|:..||:||....|:|||||::||::.:|.|:|.||.|:|:|.||..|||||.:.:||.:|:
  Fly   116 HSKPNGRACMAMKGESCHWPRGKMLGGTNGMNAMIYARGTRKDFDDWEERGNPGWGYDEVLKHFR 180

  Fly   183 KYEG--SSVPDAEEDYVGRNGPVKV-SYVN---WRSKI-----------AEAFVDAA---QQDGL 227
            |.|.  |:.||.:....|..||:.: :||:   :|:.|           |..|.:.:   |.|.|
  Fly   181 KAEDLRSTRPDYKPGDHGVGGPMGLNNYVSDNEFRTTIRAGMQEMGYGSAPDFTEGSFVGQMDIL 245

  Fly   228 KYRDYNGRIQNGVAFLHTTTRNSTRWSSNRAYLYPLKGKRSNLHVRKNALVTKVLIDPQTKTAYG 292
            ..:|...||        ||.|:.            ||....|||:.::|.|.|:.:|...:....
  Fly   246 GTQDGGRRI--------TTARSH------------LKKNTPNLHILRHAHVKKINLDRNNRAESV 290

  Fly   293 IMVQTEGRMQKILARKEVIVSAGAINTPQLLMLSGVGPAKHLREVGIKPLADLAVGYNLQDHTAP 357
            ..|....:...:.|.||||||||||.:||:|:|||:|||.||:.:||....||.||.||:||.:.
  Fly   291 TFVHRGKKEYTVKASKEVIVSAGAIGSPQILLLSGIGPADHLKSLGIPVKLDLPVGENLKDHASL 355

  Fly   358 AVTFTTNATSLKFEDFSDPT---LIN-RFNRMEGPYGSPGGCEAIAFWDLDHERDEDG-WPDIEL 417
            .:.|..:.::.:     .||   |:: .:|.:.|.|......||.|.....:....:| .|||:.
  Fly   356 PMIFQIDKSTAR-----KPTEEELVDAMYNLLMGRYSKLLHHEATALTGFINTTSIEGPNPDIQT 415

  Fly   418 --FLVGGSMSSNPAIS---RAFGLKKSIYDTLFAEIEDKSLNAFMIFPMILRPKSRGRIMLKSSD 477
              |.   |:..:|.:.   .|.|....:..::.:  .::..|.::.:.:.|:|.|.|.:.|:|::
  Fly   416 TNFF---SLMQSPELKGYVAATGFNDRVAKSILS--ANQETNTYITYLLHLKPFSAGSLTLQSAN 475

  Fly   478 PFKYPLIHANYFAHPYDVDISVRGLLKAISLMEQRGMEKINARLWEKKIPTCKQHPYKSWAYWAC 542
            ....|:|...|.....|||..:|.|....:|...:...:..|.|.:..:..|....|:|..||.|
  Fly   476 YLDAPIIDPGYMTDERDVDTYIRALNIYKNLPNTKAFSEREAALHKLDLEACNGLTYQSDDYWRC 540

  Fly   543 YVRHFTFTIYHYSGTAKMGPKSDRAAVVDHRLRVHGIKNLRVADASIMPEIMSGHPNGPVFMIAE 607
            |:||.|.|:||..||.:|||.:|..||||.:|||||.|.|||.||||||:|:..:.|....||||
  Fly   541 YIRHMTTTVYHPVGTTRMGPSTDPTAVVDPQLRVHGAKGLRVIDASIMPDIVGANTNAACIMIAE 605

  Fly   608 KAADMIKQDH 617
            |.|||||:::
  Fly   606 KGADMIKEEY 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9521	NP_572977.1	PRK02106	57..614	CDD:235000	211/590 (36%)
		NADB_Rossmann	61..>92	CDD:304358	18/30 (60%)
		NADB_Rossmann	125..356	CDD:304358	95/250 (38%)
		GMC_oxred_C	465..609	CDD:282984	60/143 (42%)
CG9512	NP_001285253.1	PRK02106	56..612	CDD:235000	211/590 (36%)
		NADB_Rossmann	120..352	CDD:304358	93/251 (37%)
		GMC_oxred_C	463..606	CDD:282984	59/142 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446466
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	11	10.800