DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9521 and CG45065

DIOPT Version :9

Sequence 1:	NP_572977.1	Gene:	CG9521 / 32414	FlyBaseID:	FBgn0030588	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001285251.1	Gene:	CG45065 / 19835504	FlyBaseID:	FBgn0266435	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	248/594 - (41%)
Similarity:	353/594 - (59%)	Gaps:	18/594 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 INFLRRGQADVELENYDNNVILDSEYDFIVVGAGTAGCALAARLSENPQWRVLLLEAGGPERLVM 99
            :||.|....|.| .......::..:|||:|:|.|:||..:|.||||...|.||||||||.|..:.
  Fly    20 MNFYRYQSVDPE-NKVQEPTVIRRQYDFVVIGGGSAGAVVANRLSEVRNWTVLLLEAGGDETEIS 83

  Fly   100 DVPIVAHFLQLGEMNWKYRTQPSD--HACLAMNNNRCNWPRGKVMGGSSVLNYMMYTRGNRRDYD 162
            |||.:|.:|||.|::|||:|.||.  ..|.||..:||.||||||:|||||||.|:|.||::.||:
  Fly    84 DVPALAGYLQLTELDWKYQTTPSSTRQYCQAMKGDRCFWPRGKVLGGSSVLNAMVYVRGSKNDYN 148

  Fly   163 RWEALGNPGWSFKDVLPYFKKYEGSSVPD-AEEDYVGRNGPVKVSYVNWRSKIAEAFVDAAQQDG 226
            .|.:||||||.:..:|.||.|.|....|. |:..|....|.:.|....||:.::.||:.|..:.|
  Fly   149 HWASLGNPGWDYDSMLKYFLKSEDVRNPYLAKTPYHETGGYLTVQEAPWRTPLSIAFLQAGIEMG 213

  Fly   227 LKYRDYNGRIQNGVAFLHTTTRNSTRWSSNRAYLYPLKGKRSNLHVRKNALVTKVLIDPQTKTAY 291
            .:.||.||..|.|.....:|.|...|.|:.:|::.|:: :|.|..|..:|..|::|.|.| |.|.
  Fly   214 YENRDINGAQQTGFMLTQSTIRRGARCSTGKAFIRPVR-QRKNFDVLLHAEATRILFDKQ-KRAI 276

  Fly   292 GIMVQTEGRMQKILARKEVIVSAGAINTPQLLMLSGVGPAKHLREVGIKPLADLAVGYNLQDHTA 356
            |:.....||...:..|:|||.||||:|||:||||||||||:||:|..|..::||.||.|:|||..
  Fly   277 GVEYMRGGRKNVVFVRREVIASAGALNTPKLLMLSGVGPAEHLQEHNIPVISDLPVGNNMQDHVG 341

  Fly   357 -PAVTFTTNA----TSLKFEDFSDPTLINRFNRMEGPYGSPGGCEAIAFWDLDHERDEDGWPDIE 416
             ..:||..:|    |..:|:..  |..:....|..||. :..|.|.:||.:..::.....|||::
  Fly   342 LGGLTFVVDAPLTVTRNRFQTI--PVSMEYILRERGPM-TFSGVEGVAFLNTKYQDPSVDWPDVQ 403

  Fly   417 LFLVGGSMSSN--PAISRAFGLKKSIYDTLFAEIEDKSLNAFMIFPMILRPKSRGRIMLKSSDPF 479
            ......|::|:  ..|.:...|:...|:|::..::..  ..:.|.|::|||||.|.:.|.|.:|.
  Fly   404 FHFCPSSINSDGGEQIRKILNLRDGFYNTVYKPLQHS--ETWSILPLLLRPKSTGWVRLNSRNPQ 466

  Fly   480 KYPLIHANYFAHPYDVDISVRGLLKAISLMEQRGMEKINARLWEKKIPTCKQHPYKSWAYWACYV 544
            ..|.|..|||||..|:|:.|.|:..||::...:..::..:||....:|.|:..|::|..||||.:
  Fly   467 HQPKIIPNYFAHQEDIDVLVEGIKLAINVSNTQAFQRFGSRLHNIPLPGCRHLPFQSNEYWACCI 531

  Fly   545 RHFTFTIYHYSGTAKMGPKSDRAAVVDHRLRVHGIKNLRVADASIMPEIMSGHPNGPVFMIAEKA 609
            :.|||||||.:||.:|||..|..||||.||||:|:..:||.||||||.|::|:||.||..|.|||
  Fly   532 KEFTFTIYHPAGTCRMGPSWDVTAVVDPRLRVYGVSGVRVVDASIMPTIVNGNPNAPVIAIGEKA 596

  Fly   610 ADMIKQDHG 618
            :|:||:|.|
  Fly   597 SDLIKEDWG 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9521	NP_572977.1	PRK02106	57..614	CDD:235000	239/566 (42%)
		NADB_Rossmann	61..>92	CDD:304358	18/30 (60%)
		NADB_Rossmann	125..356	CDD:304358	105/231 (45%)
		GMC_oxred_C	465..609	CDD:282984	68/143 (48%)
CG45065	NP_001285251.1	PRK02106	42..601	CDD:235000	239/565 (42%)
		NADB_Rossmann	117..339	CDD:304358	100/223 (45%)
		GMC_oxred_C	452..596	CDD:282984	68/143 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446468
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.890