DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9522 and Chdh

DIOPT Version :9

Sequence 1:	NP_644677.1	Gene:	CG9522 / 32413	FlyBaseID:	FBgn0030587	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_942026.1	Gene:	Chdh / 290551	RGDID:	735166	Length:	599	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	207/583 - (35%)
Similarity:	287/583 - (49%)	Gaps:	72/583 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YDFIIVGGGAAGCTLAARLSENPNWSVFLIEAG------GVENI---VHQVPLLAAHLQSTASNW 106
            |.||:||.|:|||.||.||:|:||..|.|:|||      |.:.:   :|....|.|:|.....||
  Rat    46 YTFIVVGAGSAGCVLANRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVANLCDDKYNW 110

  Fly   107 GYNSTPQRHACRGMPDNKCALPRGKVLGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPY 171
            .|::..|    .|:.......|||:|.||:||:|.|:|.||:..|::.|...|..||.|...|||
  Rat   111 YYHTEAQ----PGLDGRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWHRQGAEGWDYAHCLPY 171

  Fly   172 FLRSEHAQLQGLEHSPYHNHSGPLSVEDVRHRTRLAHAYIRAAQEAGHPRT-DYNGESQLGVSYV 235
            |.:   ||...|..:.|....|||.|...:....|..|:::||::||:|.| |.||..|.|..::
  Rat   172 FRK---AQKHELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPFTEDMNGFQQEGFGWM 233

  Fly   236 QATTLKGRRHSAFRAYIEPIRSRRHNLHILTLARVTRVLIDAATKSAYGVELTHQGRSFKVKARK 300
            ..|..:|:|.|...||:.|..| |.||.......|:|||.:..  .|.|||....|:|.|....:
  Rat   234 DMTIHQGKRWSTASAYLRPALS-RPNLRAEVQTLVSRVLFEGT--RAVGVEYIKDGQSHKAYVSR 295

  Fly   301 EIILSAGAFNSPQLLMLSGIGPEDNLKAIGIPLIKALP-VGKRMFDHMCHFGPTFVTNTTGQ--T 362
            |:|||.||.||||||||||:|..|:||.:|||::..|| ||:.:.||:    ..::.:...|  |
  Rat   296 EVILSGGAINSPQLLMLSGVGNADDLKKLGIPVVCHLPGVGQNLQDHL----EIYIQHACTQPIT 356

  Fly   363 LFAAQLGAPVAK-----EFL---LGRADTFLSSIGGVETLTFIKVPSGKSPATQPDVELIQVAGS 419
            |.:||  .|:.|     |:|   .|...|.....||     ||:...|   ...||:: .....|
  Rat   357 LHSAQ--KPLRKVCIGLEWLWRFTGDGATAHLETGG-----FIRSRPG---VPHPDIQ-FHFLPS 410

  Fly   420 LASDDGTALAKGANFKPEIYEKMYKNLTLRQQDHFSFLIMHFKPASVGRLWLHNRNPLEWPRIDP 484
            ...|.|.        ||            .||:.:...:...:..|||.|.|.:.||.:.|.|:|
  Rat   411 QVIDHGR--------KP------------TQQEAYQVHVGTMRATSVGWLKLRSTNPQDHPMINP 455

  Fly   485 KYFSAPSDVENLLEGIKEALRISKMPAMQAIGTRLLDKPVPGCENYEFASDDYWRCSIRTLSYTL 549
            .|.|..:|||:..:.:|....|....|......:.|.   ||.   ...||......:|..:.:.
  Rat   456 NYLSTETDVEDFRQCVKLTREIFAQEAFAPFRGKELQ---PGS---HVQSDKEIDAFVRAKADSA 514

  Fly   550 HHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIR 612
            :|...||:||..||||.||:.|.:|.||..|||:|.||:|...:.:.||...||.|||||:|:
  Rat   515 YHPSCTCKMGQPSDPTAVVDQQTRVIGVENLRVIDASIMPSVVSGNLNAPTIMIAEKAADVIK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9522	NP_644677.1	PRK02106	48..612	CDD:235000	206/581 (35%)
		NADB_Rossmann	52..>83	CDD:304358	18/30 (60%)
		NADB_Rossmann	127..348	CDD:304358	95/222 (43%)
		GMC_oxred_C	463..607	CDD:282984	51/143 (36%)
Chdh	NP_942026.1	PRK02106	45..591	CDD:235000	207/583 (36%)
		NADB_Rossmann	49..>151	CDD:304358	42/105 (40%)
		GMC_oxred_N	121..344	CDD:279121	95/232 (41%)
		GMC_oxred_C	435..572	CDD:282984	51/142 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2129
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2269
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm44531
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870