DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9522 and chdh-1

DIOPT Version :9

Sequence 1:	NP_644677.1	Gene:	CG9522 / 32413	FlyBaseID:	FBgn0030587	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_495846.1	Gene:	chdh-1 / 174390	WormBaseID:	WBGene00007917	Length:	599	Species:	Caenorhabditis elegans

Alignment Length:	654	Identity:	194/654 - (29%)
Similarity:	301/654 - (46%)	Gaps:	136/654 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 HSQRSSQLDELRRLGLGNVVNVPFFS-DVPQRNYDFIIVGGGAAGCTLAARLSENPNWSVFLIEA 82
            |:.||.|....|.:...:.:....|| |:.:.....||||.|:|||.||.||:|:|:..|.||||
Worm     5 HAARSLQRTSKRWINWRDSMKEGTFSADIAENKPTHIIVGAGSAGCVLANRLTEDPSNRVLLIEA 69

  Fly    83 GGVEN----IVHQVPLLAAHLQSTASNWGYNSTPQRHACRGMPDNKCALPRGKVLGGTSSINYMI 143
            |.|::    .:|....|..:|.|...||.|::|.|::    :.:.....|||:|.||:|::|.|.
Worm    70 GPVDHKWDWRIHMPAALMYNLCSDTYNWHYHTTAQKN----LGNRVFYWPRGRVWGGSSTLNAMC 130

  Fly   144 YNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSE-HAQLQGLEHSPYHNHSGPLSVEDVRHRTRLA 207
            |.||:..|::.|...|..||:|...||||.::| ::...| .:.||..::|||.|:.......|.
Worm   131 YVRGHAYDYNRWEKEGASGWNYANCLPYFKKAETYSDATG-PNDPYRGNNGPLYVKKGDAENPLH 194

  Fly   208 HAYIRAAQEAGHP---RTDYNGESQLGVSYVQATTLKGRRHSAFRAYIEPIRSRRHNLHILTLAR 269
            .|::...:|  ||   ..|.|||.|.|:|.:..|...|.|.||.:||:.|||:|.   :::|.:.
Worm   195 KAWLNVGKE--HPLGWTNDMNGEKQEGISTMDMTIHNGERWSASKAYVHPIRNRP---NLITSSG 254

  Fly   270 V--TRVLIDAATKSAYGVEL--------THQGRSF---KVKARKEIILSAGAFNSPQLLMLSGIG 321
            :  ||||.|  |..|.|:|.        |....|:   |:..:.::||:.||.|:||||||||:|
Worm   255 ITCTRVLFD--TNKAIGIEFIRKLNFVGTDSIDSYSREKIYCQGDVILAGGAINTPQLLMLSGVG 317

  Fly   322 PEDNLKAIGIPLIKALP-VGKRMFDH--------------------------MCHFGPTFVTNTT 359
            |.|:|::..||::..|| ||:.:.||                          |...|..:.||.|
Worm   318 PADHLRSHEIPIVANLPGVGQNLQDHLEIYVQQESTQPVTLYNKSSWKFPHNMIKIGLEWFTNRT 382

  Fly   360 GQTLFAAQLGAPVAKEFLLGRADTFLSSIGGVETLTFIKVPSGKSPATQPDVELIQVAGSLASDD 424
            |       |||.                 ..:||..|.:   .....|.||:: .....|...||
Worm   383 G-------LGAS-----------------SHLETGGFAR---SDDTVTHPDIQ-FHFLPSTVHDD 419

  Fly   425 GTALAKGANFKPEIYEKMYKNLTLRQQDHFSFLIMHFKP---ASVGRLWLHNRNPLEWPRIDPKY 486
            |........::                       :|..|   .|.|.:.|..::|...|.|:|.|
Worm   420 GRTNGTCHGYQ-----------------------VHVGPMRSQSKGYIMLQAKDPRRAPIINPNY 461

  Fly   487 FSAPSDVENLLEGIKEALRISKMPAMQAIGTRLLDK-------PVPGCENYEFASDDYWRCSIRT 544
            ....||...    .::.:|:|:    :...::..|:       |.|.|:     ||......::.
Worm   462 MEEDSDWRE----FRKCIRVSR----ELFASKAFDEFRGKELAPGPDCQ-----SDADIDRFVKE 513

  Fly   545 LSYTLHHQVATCRMGAESDPTTVVNHQ-LKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAA 608
            .:.:.:|...||:||:|:|...|||.: :.|:|...|:|||.|::|...:.:.||...|:.|:||
Worm   514 KAASAYHPSCTCKMGSENDKMAVVNPETMGVYGTENLKVVDASVMPSIVSGNLNAPVIMMAERAA 578

  Fly   609 DMIR 612
            |:|:
Worm   579 DLIK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9522	NP_644677.1	PRK02106	48..612	CDD:235000	185/622 (30%)
		NADB_Rossmann	52..>83	CDD:304358	18/30 (60%)
		NADB_Rossmann	127..348	CDD:304358	91/264 (34%)
		GMC_oxred_C	463..607	CDD:282984	41/154 (27%)
chdh-1	NP_495846.1	PRK02106	41..599	CDD:235000	186/618 (30%)
		NADB_Rossmann	41..>78	CDD:304358	21/36 (58%)
		NADB_Rossmann	108..345	CDD:304358	91/244 (37%)
		GMC_oxred_C	439..577	CDD:282984	40/150 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	214	1.000	Domainoid score	I1583
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I1553
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm14159
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870