DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12539 and HTH

DIOPT Version :9

Sequence 1:	NP_572976.1	Gene:	CG12539 / 32412	FlyBaseID:	FBgn0030586	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_565050.1	Gene:	HTH / 843628	AraportID:	AT1G72970	Length:	594	Species:	Arabidopsis thaliana

Alignment Length:	621	Identity:	159/621 - (25%)
Similarity:	234/621 - (37%)	Gaps:	169/621 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SNYDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGV----ENIAHLTPVVAGYLQQTSSNWGYK 116
            |:||:||||.|.|||.|||.||:|  .||.::|.|||    .|::.|.....|....::|:....
plant    61 SSYDYIVIGGGTAGCPLAATLSQN--FSVLVLERGGVPFTNANVSFLRNFHIGLADISASSASQA 123

  Fly   117 SVPQKLSCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLR 181
            .|    |..|:.|     .|.::|||.|.||...|:|.     || |.....||.     |..::
plant   124 FV----STDGVYN-----ARARVLGGGSCINAGFYSRA-----DA-AFVKRAGWD-----PKLVK 168

  Fly   182 SEHAQLQGLEQSPYHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPRTDYNGESQLGVSYVQ-AN 245
            ..:   ..:|:...|.....|      ::..:.|:.:|..|.      .:||.:...||..: ..
plant   169 ESY---PWVEREIVHQPKLTL------WQKALRDSLLEVGVR------PFNGFTYDHVSGTKIGG 218

  Fly   246 TL---NGRRHSAYS--AYIKPVRDLRSNLQIFTFSQVTRILIDEA--TKSAYGVEFHYKNKAYTF 303
            |:   .||||:|..  ||..|     ..|::..::.|.:|:.|.:  .....||.|. ..|....
plant   219 TIFDRFGRRHTAAELLAYANP-----QKLRVLIYATVQKIVFDTSGTRPRVTGVIFK-DEKGNQH 277

  Fly   304 KA----RK--EVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLI-KALPVGKRMFDHMCHFGPTF 361
            :|    ||  |||||:|:..|||:||||||||:..|:.:.||:: :...|||.|.|:..:
plant   278 QALLSNRKGSEVILSSGAIGSPQMLMLSGIGPKKELQRLKIPVVLENEHVGKGMADNPMN----- 337

  Fly   362 VTNTTGQTTFTSRVTPAELISFLLAGNPATRMSSIGGVEALAFLKTQRSNLPNDWPDIELIMVTG 426
                   |.......|.|.......|  .|:|...  |||                      .||
plant   338 -------TILVPSKAPIEQSLIQTVG--ITKMGVY--VEA----------------------STG 369

  Fly   427 SLASDEGTGLKLG-ANFKDEIYDRM--YRELAQAQQDHFTLLIMQFH--------------PKSV 474
            ...|.|......| .:.|:|::..:  .:...:|.|.:.|....|.|              |.|.
plant   370 FGQSPESIHTHYGIMSNKNELFSTIPAKQRRPEATQAYITRNKYQLHEAFNGSFILEKLAYPISR 434

  Fly   475 GRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGH- 538
            |.|.|.:.|....|.:...||....|::..::.|:...:::       ...|.|..|  .|:..
plant   435 GHLSLVNTNVDDNPSVTFNYFKHPVDLQRCVEAIRLVSKVV-------TSNRFLNYT--QCDKQN 490

  Fly   539 ---------------------------QFASDDYWRCSIRTLSYTLHHQVATCRMGAESDPTTVV 576
                                       ||..|..         .|:.|....|.:|      .||
plant   491 VHKMLSLSVKANINLRPKQLNDTKSMAQFCKDTV---------VTIWHYHGGCLVG------KVV 540

  Fly   577 NHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIG 612
            :...||.||.:|||:|.|.....|..:..|...|:|
plant   541 SPNRKVLGVDRLRVIDGSTFDESPGTNPQATMMMMG 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	158/619 (26%)
		NADB_Rossmann	59..>90	CDD:304358	18/30 (60%)
		NADB_Rossmann	128..355	CDD:304358	71/241 (29%)
		GMC_oxred_C	471..615	CDD:282984	37/170 (22%)
HTH	NP_565050.1	PLN02785	18..594	CDD:215420	159/621 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D798314at2759
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		mtm950
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770