DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12539 and AT1G12570

DIOPT Version :9

Sequence 1:	NP_572976.1	Gene:	CG12539 / 32412	FlyBaseID:	FBgn0030586	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_172718.2	Gene:	AT1G12570 / 837814	AraportID:	AT1G12570	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	684	Identity:	173/684 - (25%)
Similarity:	262/684 - (38%)	Gaps:	214/684 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QLFLLLHLLIFTTVARGDVNRLVLDQLNQVGLVNLIEQATRPNVPRD------LSNYDFIVIGAG 66
            :||:.|.|.:.:.:...|                   :|...:..||      .|.||:|:||.|
plant     9 RLFVALSLFLHSPICSSD-------------------KAPNYSFMRDATGSPTTSYYDYIIIGGG 54

  Fly    67 AAGCTLAARLSENPQVSVALIEAG----GVENIAHLTPVVAGYLQQTSSNWGYKSVPQKLSCHGM 127
            .|||.|||.||:|  .||.|:|.|    ...||..|:...|.....:.|:...:.|.:    .|:
plant    55 TAGCPLAATLSQN--ASVLLLERGDSPYNNPNITRLSAFGAALSDLSESSPSQRFVSE----DGV 113

  Fly   128 NNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSEHAQLQGLE- 191
            .|     .|.::|||.|::|...|.|...:      ...|.||  |..|      .:...|.:|
plant   114 IN-----ARARVLGGGSALNAGFYTRAGTK------YVRNMGW--DGAL------ANESYQWVEA 159

  Fly   192 ----QSPYHNHSGPLSVEYVRFRSQMVDAFVEASV--ESGLPRTDYNGESQLGVSYVQANTLNGR 250
                |.|..           |:::.:.|..:||.:  .:|......||....|..:.:    ||.
plant   160 KVAFQPPMG-----------RWQTAVRDGLLEAGIVPNNGFTYDHINGTKFGGTIFDR----NGN 209

  Fly   251 RHSAYS--AYIKPVRDLRSNLQIFTFSQVTRILIDE--ATKS-AYGVEFHYK----NKAYTFK-A 305
            ||:|..  .|..|     ..:.:...:.|.|||...  .||. |.||.:..:    ::||..: |
plant   210 RHTAADLLEYADP-----KGITVLLHATVHRILFRTRGTTKPIANGVVYRDRTGQAHRAYLKEGA 269

  Fly   306 RKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFGPTFVTNTTGQT 369
            ..|:|||||:..|||||||||:||...|:...|.::...| ||:.|:|
plant   270 LSEIILSAGTLGSPQLLMLSGVGPSAQLQAQNITVVMDQPHVGQGMYD----------------- 317

  Fly   370 TFTSRVTPAELISFLLAGNPATRMSSIGGVEALAFLKTQRSNLPNDWPDIELIMVTGSLASDEGT 434
                              ||   |:::       |:.   |.:|.:...||::.:||     |||
plant   318 ------------------NP---MNAV-------FVP---SPVPVEVSLIEVVGITG-----EGT 346

  Fly   435 GLKL--GANF-------------KDEIYDRMY------------RELAQAQ--QDHFTLLIMQFH 470
            .::.  |.||             :|  |..|:            .:|:.||  |..| ||.....
plant   347 YVEAAGGENFGGGGGGSSGSSSTRD--YYAMFSPRATLLESNSMTKLSSAQPFQGGF-LLEKVMG 408

  Fly   471 PKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQR-----IGARLL-- 528
            |.|.|.|.||.|||...|.:...||...:|::..:.||:...|:::..|..|     :....|
plant   409 PLSTGHLELKTRNPKDNPIVTFNYFQHPDDLKRCVRGIQTIERVVQSKAFSRYKYADVSFEYLLN 473

  Fly   529 -----------KRTVPGC----EGHQFASDDYWRCSIRTLSYTLHHQVATCRMGAESDPTTVVNH 578
                       .|:.||.    ...:|..        .|:: |:.|....|.:|      .||:.
plant   474 LTASTPVNLRPPRSGPGASLPPSAEEFCQ--------HTVT-TIWHYHGGCVVG------RVVDG 523

  Fly   579 QLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIG 612
            ..||.|:.:|||:|.|.:.:.|..:..|...|:|
plant   524 DYKVIGIDRLRVIDMSTVGYCPGTNPQATVMMLG 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	164/628 (26%)
		NADB_Rossmann	59..>90	CDD:304358	18/30 (60%)
		NADB_Rossmann	128..355	CDD:304358	69/244 (28%)
		GMC_oxred_C	471..615	CDD:282984	42/164 (26%)
AT1G12570	NP_172718.2	PLN02785	10..572	CDD:215420	173/683 (25%)
		NADB_Rossmann	46..301	CDD:304358	90/299 (30%)
		NADB_Rossmann	47..>100	CDD:304358	23/54 (43%)
		GMC_oxred_C	409..557	CDD:282984	41/162 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D798314at2759
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		mtm950
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770