Protein Alignment CG12539 and CHDH

DIOPT Version :10

• Sequence 1: NP_572976.1
• Gene: CG12539 / 32412
• FlyBaseID: FBgn0030586
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_060867.2
• Gene: CHDH / 55349
• HGNCID: 24288
• Length: 594
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 205/615 - (33%)
• Similarity: 295/615 - (47%)
• Gaps: 72/615 - (11%)

  Fly    24 GDVNRLVLDQLNQVGLVNLIEQATRPNVPRDLSNYDFIVIGAGAAGCTLAARLSENPQVSVALIE 88
            |.:.|..|.|...:|...|   |:..:..||  .|.::|:|||:|||.||.||:|:|...|.|:|
Human    12 GALARGALGQQQSLGARAL---ASAGSESRD--EYSYVVVGAGSAGCVLAGRLTEDPAERVLLLE 71

  Fly    89 AGGVENIA---------HLTPVVAGYLQQTSSNWGYKSVPQKLSCHGMNNNECALPRGKILGGTS 144
            ||..:.:|         |:...:...|.....||.|.:..|:    |::......|||::.||:|
Human    72 AGPKDVLAGSKRLSWKIHMPAALVANLCDDRYNWCYHTEVQR----GLDGRVLYWPRGRVWGGSS 132

  Fly   145 SINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSEHAQLQGLEQSPYHNHSGPLSVEYVRF 209
            |:|.|:|.||:..|::.|...|..||.|...||||.:   ||...|..|.|....|||.|...:.
Human   133 SLNAMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRK---AQGHELGASRYRGADGPLRVSRGKT 194

  Fly   210 RSQMVDAFVEASVESGLPRT-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDLRSNLQIFT 273
            ...:..||:||:.::|.|.| |.||..|.|..::......|:|.||..||:.|... |:||:...
Human   195 NHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSAACAYLHPALS-RTNLKAEA 258

  Fly   274 FSQVTRILIDEATKSAYGVEFHYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGI 338
            .:.|:|:|. |.|: |.|||:....:::...|.||||||.|:.||||||||||||..|:|:.:||
Human   259 ETLVSRVLF-EGTR-AVGVEYVKNGQSHRAYASKEVILSGGAINSPQLLMLSGIGNADDLKKLGI 321

  Fly   339 PLIKALP-VGKRMFDHMCHFGPTFVTNT-TGQTTFTSRVTPAELISFLL------AGNPATRMSS 395
            |::..|| ||:.:.||:    ..::... |...|..|...|...:...|      .|..||....
Human   322 PVVCHLPGVGQNLQDHL----EIYIQQACTRPITLHSAQKPLRKVCIGLEWLWKFTGEGATAHLE 382

  Fly   396 IGGVEALAFLKTQRSNLPNDWPDIELIMVTGSLASDEGTGLKLGANFKDEIYDRMYRELAQAQQD 460
            .||     |:::| ..:|:  |||:...:. |...|.|.                    ...||:
Human   383 TGG-----FIRSQ-PGVPH--PDIQFHFLP-SQVIDHGR--------------------VPTQQE 418

  Fly   461 HFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGA 525
            .:.:.:......|||.|.|:..||...|.|.|.|...|.|:|.....:|.:..|....|:.....
Human   419 AYQVHVGPMRGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALAPFRG 483

  Fly   526 RLLKRTVPGCEGHQFASDDYWRCSIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRV 590
            :.|:      .|....||......:|..:.:.:|...||:||..||||.||:.|.:|.||..|||
Human   484 KELQ------PGSHIQSDKEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENLRV 542

  Fly   591 VDTSIIPFPPTAHTNAAAFMIGEKAADMIR 620
            ||.||:|...:.:.||...||.|||||:|:
Human   543 VDASIMPSMVSGNLNAPTIMIAEKAADIIK 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	BetA	58..622	CDD:441878	196/581 (34%)
CHDH	NP_060867.2	PRK02106	40..594	CDD:235000	196/582 (34%)