DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12539 and CG9514

DIOPT Version :9

Sequence 1:	NP_572976.1	Gene:	CG12539 / 32412	FlyBaseID:	FBgn0030586	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_572981.1	Gene:	CG9514 / 32418	FlyBaseID:	FBgn0030592	Length:	726	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	234/588 - (39%)
Similarity:	342/588 - (58%)	Gaps:	12/588 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NLIEQATRP-NVPR-DLSNYDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGVENIAHLTPVVA 103
            :|.:...|| ||.: ||: ||||:||.|:||..||:||||.|...:.|:||||.|......|:::
  Fly    77 DLFDPENRPFNVQQVDLA-YDFIIIGGGSAGTVLASRLSEIPHWKILLLEAGGHETEISDVPLLS 140

  Fly   104 GYLQQTSSNWGYKSVPQKLSCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNP 168
            .||.::..:|.|::.||..:|..|.:..|...|||:|||:|.:|.|:|.|||:||||.||..|||
  Fly   141 LYLHKSKMDWKYRTQPQPTACQAMKDKRCCWTRGKVLGGSSVLNTMLYIRGNKRDFDQWADFGNP 205

  Fly   169 GWSYDEVLPYFLRSEHAQLQGLEQSP-YHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPRTDYN 232
            ||||:::||||.:||..:...|.::. ||...|..:|:...:.:.:..||::|..|.|....|.|
  Fly   206 GWSYEDILPYFRKSEDQRNPYLARNKRYHGTGGLWTVQDAPYNTPIGPAFLQAGEEMGYDIVDVN 270

  Fly   233 GESQLGVSYVQANTLNGRRHSAYSAYIKPVRDLRSNLQIFTFSQVTRILIDEATKSAYGVEFHYK 297
            ||.|.|..:.|.|...|.|.|...::::|.| ||.||.:..||.||::|.|..||.|.||:|...
  Fly   271 GEQQTGFGFYQFNMRRGSRSSTAKSFLRPAR-LRPNLHVALFSHVTKVLTDPHTKRATGVQFIRD 334

  Fly   298 NKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFGPTF 361
            .:.....|.:|||||||:..||.|:||||||..:.|..:||||::.|| ||:.:.||:...|..|
  Fly   335 GRLQNVYATREVILSAGAIGSPHLMMLSGIGHGEELGRVGIPLVQHLPGVGQNLQDHIAVGGIAF 399

  Fly   362 VTNTTGQTTFTSRVTPAELISFLLA-GNPATRMSSIGGVEALAFLKTQRSNLPNDWPDIELIMVT 425
            :.:..........|.....:.:.:. ..|.|  ||| |:||:||:.|:.:|..:||||:..:|.:
  Fly   400 LIDYPISIVMKRMVNINTALRYAITEDGPLT--SSI-GLEAVAFINTKYANASDDWPDMNFMMTS 461

  Fly   426 GSLASDEGTGLKLGANFKDEIYDRMYRELAQAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKI 490
            .|:.||.|:.:|......||.|..::.|:  ..:|.|.:..|...|||.|.:.|..:|||.:|.:
  Fly   462 ASVMSDGGSQVKTAHGLTDEFYQEVFGEV--NNRDVFGVFPMMLRPKSRGYIKLASKNPLRYPLL 524

  Fly   491 DPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGHQFASDDYWRCSIRTLSY 555
            ...|....:||..|.:|:||::.:.|..||:|.|||...:.||.|:.....:||||.|.||..:.
  Fly   525 YHNYLTHPDDVNVLREGVKAAVAMGETQAMKRFGARYWNKPVPNCKHLTLYTDDYWNCFIRQYTM 589

  Fly   556 TLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIR 620
            |::|...|.:||..:||..||:.||:|:|:..|||:|.||:|.....:.:|...|||||.||||:
  Fly   590 TIYHMSGTAKMGPPTDPWAVVDPQLRVYGIPGLRVIDASIMPAITNGNIHAPVVMIGEKGADMIK 654

  Fly   621 TDW 623
            ..|
  Fly   655 QLW 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	225/564 (40%)
		NADB_Rossmann	59..>90	CDD:304358	17/30 (57%)
		NADB_Rossmann	128..355	CDD:304358	100/228 (44%)
		GMC_oxred_C	471..615	CDD:282984	58/143 (41%)
CG9514	NP_572981.1	PRK02106	95..679	CDD:235000	227/569 (40%)
		NADB_Rossmann	96..>126	CDD:304358	16/29 (55%)
		NADB_Rossmann	167..391	CDD:304358	98/224 (44%)
		GMC_oxred_C	505..648	CDD:282984	57/142 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	10	9.870