DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12539 and Chdh

DIOPT Version :9

Sequence 1:	NP_572976.1	Gene:	CG12539 / 32412	FlyBaseID:	FBgn0030586	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_942026.1	Gene:	Chdh / 290551	RGDID:	735166	Length:	599	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	193/581 - (33%)
Similarity:	282/581 - (48%)	Gaps:	67/581 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEAG------GVENI---AHLTPVVAGYLQQTSSNW 113
            |.|||:|||:|||.||.||:|:|...|.|:|||      |.:.:   .|:...:...|.....||
  Rat    46 YTFIVVGAGSAGCVLANRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVANLCDDKYNW 110

  Fly   114 GYKSVPQKLSCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPY 178
            .|.:..|.    |::......|||::.||:||:|.|:|.||:..|::.|...|..||.|...|||
  Rat   111 YYHTEAQP----GLDGRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWHRQGAEGWDYAHCLPY 171

  Fly   179 FLRSEHAQLQGLEQSPYHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPRT-DYNGESQLGVSYV 242
            |.:   ||...|..:.|....|||.|...:....:..||::|:.::|.|.| |.||..|.|..::
  Rat   172 FRK---AQKHELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPFTEDMNGFQQEGFGWM 233

  Fly   243 QANTLNGRRHSAYSAYIKPVRDLRSNLQIFTFSQVTRILIDEATKSAYGVEFHYKNKAYTFKARK 307
            ......|:|.|..|||::|... |.||:....:.|:|:|. |.|: |.|||:....:::.....:
  Rat   234 DMTIHQGKRWSTASAYLRPALS-RPNLRAEVQTLVSRVLF-EGTR-AVGVEYIKDGQSHKAYVSR 295

  Fly   308 EVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFGPTFVTNT-TGQTT 370
            |||||.|:.||||||||||:|..|:|:.:|||::..|| ||:.:.||:    ..::.:. |...|
  Rat   296 EVILSGGAINSPQLLMLSGVGNADDLKKLGIPVVCHLPGVGQNLQDHL----EIYIQHACTQPIT 356

  Fly   371 FTSRVTPAELISFLL------AGNPATRMSSIGGVEALAFLKTQRSNLPNDWPDIELIMVTGSLA 429
            ..|...|...:...|      .|:.||.....||     |::: |..:|:  |||:...:. |..
  Rat   357 LHSAQKPLRKVCIGLEWLWRFTGDGATAHLETGG-----FIRS-RPGVPH--PDIQFHFLP-SQV 412

  Fly   430 SDEGTGLKLGANFKDEIYDRMYRELAQAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKY 494
            .|.|.                    ...||:.:.:.:......|||.|.|:..||...|.|:|.|
  Rat   413 IDHGR--------------------KPTQQEAYQVHVGTMRATSVGWLKLRSTNPQDHPMINPNY 457

  Fly   495 FVAEEDVEYLLDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGHQFASDDYWRCSIRTLSYTLHH 559
            ...|.|||.....:|.:..|....|......:.|:      .|....||......:|..:.:.:|
  Rat   458 LSTETDVEDFRQCVKLTREIFAQEAFAPFRGKELQ------PGSHVQSDKEIDAFVRAKADSAYH 516

  Fly   560 QVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIR 620
            ...||:||..||||.||:.|.:|.||..|||:|.||:|...:.:.||...||.|||||:|:
  Rat   517 PSCTCKMGQPSDPTAVVDQQTRVIGVENLRVIDASIMPSVVSGNLNAPTIMIAEKAADVIK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	192/579 (33%)
		NADB_Rossmann	59..>90	CDD:304358	18/30 (60%)
		NADB_Rossmann	128..355	CDD:304358	88/228 (39%)
		GMC_oxred_C	471..615	CDD:282984	50/143 (35%)
Chdh	NP_942026.1	PRK02106	45..591	CDD:235000	193/581 (33%)
		NADB_Rossmann	49..>151	CDD:304358	39/105 (37%)
		GMC_oxred_N	121..344	CDD:279121	88/232 (38%)
		GMC_oxred_C	435..572	CDD:282984	50/142 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6373
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2269
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm44531
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780