Protein Alignment CG12539 and Chdh

DIOPT Version :9

• Sequence 1: NP_572976.1
• Gene: CG12539 / 32412
• FlyBaseID: FBgn0030586
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_001129712.1
• Gene: Chdh / 218865
• MGIID: 1860776
• Length: 596
• Species: Mus musculus
• Alignment Length: 592
• Identity: 202/592 - (34%)
• Similarity: 288/592 - (48%)
• Gaps: 75/592 - (12%)

  Fly    50 NVPRDLSNYDFIVIGAGAAGCTLAARLSENPQVSVALIEAG------GVENI---AHLTPVVAGY 105
            :|.:|  .|.|:|:|||:|||.||:||:|:|...|.|:|||      |.:.:   .|:...:...
Mouse    37 SVGKD--EYTFVVVGAGSAGCVLASRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVSN 99

  Fly   106 LQQTSSNWGYKSVPQKLSCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGW 170
            |.....||.|.:.||.    ||::.....|||::.||:||:|.|:|.||:..|::.|...|..||
Mouse   100 LCDDKYNWYYHTEPQP----GMDSRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWHREGAEGW 160

  Fly   171 SYDEVLPYFLRSEHAQLQGLEQSPYHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPRT-DYNGE 234
            .|...||||.:   ||...|..:.|....|||.|...:....:..||::|:.::|.|.| |.||.
Mouse   161 DYAHCLPYFRK---AQRHELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPFTEDMNGF 222

  Fly   235 SQLGVSYVQANTLNGRRHSAYSAYIKPVRDLRSNLQIFTFSQVTRILIDEATKSAYGVEF---HY 296
            .|.|..::......|:|.|...||:.||.. |.||:....:.|:|:|. |.|: |.|||:   ..
Mouse   223 QQEGFGWMDMTVHQGKRWSTACAYLHPVLS-RPNLRAEVQTLVSRVLF-EGTR-AVGVEYIKDGQ 284

  Fly   297 KNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFGPT 360
            ::|||   ..:|||||.|:.||||||||||:|..|:||.:.||::..|| ||:.:.||:    ..
Mouse   285 RHKAY---VSREVILSGGAINSPQLLMLSGVGNADDLRKLDIPVVCHLPGVGQNLQDHL----EV 342

  Fly   361 FVTNT-TGQTTFTSRVTPAELISFLL------AGNPATRMSSIGGVEALAFLKTQRSNLPNDWPD 418
            :|... |...|..|...|...:...|      .|:.||.....||     |::: |..:|:  ||
Mouse   343 YVQQACTQPITLHSAQKPLRKVCIGLEWLWSYTGDGATAHLETGG-----FIRS-RPGVPH--PD 399

  Fly   419 IELIMVTGSLASDEGTGLKLGANFKDEIYDRMYRELAQAQQDHFTLLIMQFHPKSVGRLWLKDRN 483
            |:...:. |...|.|.                    ...||:.:.:.:......|||.|.|:..|
Mouse   400 IQFHFLP-SQVIDHGR--------------------KPTQQEAYQVHVGTMRATSVGWLKLRSAN 443

  Fly   484 PLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGHQFASDDYWRC 548
            |...|.|.|.|...|.|||.....::.|..|....|:.....:.|:      .|....||.....
Mouse   444 PRDHPVIHPNYLSTETDVEDFRQCVRLSREIFAQEALAPFRGKELQ------PGSHVQSDKEIDA 502

  Fly   549 SIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGE 613
            .:|..:.:.:|...||:||..||||.||:.|.||.||..|||||.||:|...:.:.||...||.|
Mouse   503 FVRAKADSAYHPSCTCKMGRSSDPTAVVDAQTKVIGVENLRVVDASIMPSVVSGNLNAPTVMIAE 567

  Fly   614 KAADMIR 620
            ||||:|:
Mouse   568 KAADIIK 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	199/582 (34%)
		NADB_Rossmann	59..>90	CDD:304358	17/30 (57%)
		NADB_Rossmann	128..355	CDD:304358	91/231 (39%)
		GMC_oxred_C	471..615	CDD:282984	52/143 (36%)
Chdh	NP_001129712.1	PRK02106	42..588	CDD:235000	200/585 (34%)
		NAD_binding_8	47..>76	CDD:290186	17/28 (61%)
		GMC_oxred_N	118..341	CDD:279121	91/235 (39%)
		GMC_oxred_C	432..569	CDD:282984	52/142 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6569
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm42468
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770