Protein Alignment CG12539 and chdh-1

DIOPT Version :10

• Sequence 1: NP_572976.1
• Gene: CG12539 / 32412
• FlyBaseID: FBgn0030586
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_495846.1
• Gene: chdh-1 / 174390
• WormBaseID: WBGene00007917
• Length: 599
• Species: Caenorhabditis elegans
• Alignment Length: 602
• Identity: 185/602 - (30%)
• Similarity: 283/602 - (47%)
• Gaps: 90/602 - (14%)

  Fly    61 IVIGAGAAGCTLAARLSENPQVSVALIEAGGVEN----IAHLTPVVAGYLQQTSSNWGYKSVPQK 121
            |::|||:|||.||.||:|:|...|.|||||.|::    ..|:...:...|...:.||.|.:..||
 Worm    41 IIVGAGSAGCVLANRLTEDPSNRVLLIEAGPVDHKWDWRIHMPAALMYNLCSDTYNWHYHTTAQK 105

  Fly   122 LSCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSE-HA 185
                .:.|.....|||::.||:|::|.|.|.||:..|::.|...|..||:|...||||.::| ::
 Worm   106 ----NLGNRVFYWPRGRVWGGSSTLNAMCYVRGHAYDYNRWEKEGASGWNYANCLPYFKKAETYS 166

  Fly   186 QLQGLEQSPYHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPRT-DYNGESQLGVSYVQANTLNG 249
            ...| ...||..::|||.|:.....:.:..|::....|..|..| |.|||.|.|:|.:.....||
 Worm   167 DATG-PNDPYRGNNGPLYVKKGDAENPLHKAWLNVGKEHPLGWTNDMNGEKQEGISTMDMTIHNG 230

  Fly   250 RRHSAYSAYIKPVRDLRSNLQIFTFSQVTRILIDEATKSAYGVEF--------------HYKNKA 300
            .|.||..||:.|:|: |.||...:....||:|.|  |..|.|:||              :.:.|.
 Worm   231 ERWSASKAYVHPIRN-RPNLITSSGITCTRVLFD--TNKAIGIEFIRKLNFVGTDSIDSYSREKI 292

  Fly   301 YTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFGPTFVTN 364
            |   .:.:|||:.|:.|:||||||||:||.|:||...||::..|| ||:.:.||:    ..:|
 Worm   293 Y---CQGDVILAGGAINTPQLLMLSGVGPADHLRSHEIPIVANLPGVGQNLQDHL----EIYV-- 348

  Fly   365 TTGQTTFTSRVTPAELISFLLAGNPATRMSSIG--------GVEALAFLKT---QRSNLPNDWPD 418
               |...|..||.....|:....|    |..||        |:.|.:.|:|   .||:.....||
 Worm   349 ---QQESTQPVTLYNKSSWKFPHN----MIKIGLEWFTNRTGLGASSHLETGGFARSDDTVTHPD 406

  Fly   419 IELIMVTGSLASD---EGTGLKLGANFKDEIYDRMYRELAQAQQDHFTLLIMQFHPKSVGRLWLK 480
            |:...:..::..|   .||                    ....|.|    :.....:|.|.:.|:
 Worm   407 IQFHFLPSTVHDDGRTNGT--------------------CHGYQVH----VGPMRSQSKGYIMLQ 447

  Fly   481 DRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGHQFASDDY 545
            .::|...|.|:|.|...:.|.......|:.|..:....|......   |...||.:....|..|.
 Worm   448 AKDPRRAPIINPNYMEEDSDWREFRKCIRVSRELFASKAFDEFRG---KELAPGPDCQSDADIDR 509

  Fly   546 WRCSIRTLSYTLHHQVATCRMGAESDPTTVVNHQ-LKVHGVRKLRVVDTSIIPFPPTAHTNAAAF 609
            :   ::..:.:.:|...||:||:|:|...|||.: :.|:|...|:|||.|::|...:.:.||...
 Worm   510 F---VKEKAASAYHPSCTCKMGSENDKMAVVNPETMGVYGTENLKVVDASVMPSIVSGNLNAPVI 571

  Fly   610 MIGEKAADMIRTDWELI 626
            |:.|:|||:|:...:|:
 Worm   572 MMAERAADLIKHKKQLL 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	BetA	58..622	CDD:441878	184/596 (31%)
chdh-1	NP_495846.1	Rossmann-fold NAD(P)(+)-binding proteins	41..599	CDD:473865	185/602 (31%)