DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12539 and chdh

DIOPT Version :9

Sequence 1:	NP_572976.1	Gene:	CG12539 / 32412	FlyBaseID:	FBgn0030586	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_002663301.2	Gene:	chdh / 100331020	ZFINID:	ZDB-GENE-120111-1	Length:	585	Species:	Danio rerio

Alignment Length:	596	Identity:	192/596 - (32%)
Similarity:	284/596 - (47%)	Gaps:	71/596 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IEQATRPNVPRDLSNYDFIVIGAGAAGCTLAARLSENPQVSVALIEAG------GVENIA---HL 98
            |......|.|    :|.::::|||:|||.||:||:|||..||.|:|||      |...::   |:
Zfish    24 ISTVVNKNTP----SYSYVIVGAGSAGCVLASRLTENPSDSVLLLEAGPKDKHLGSTRLSWKIHM 84

  Fly    99 TPVVAGYLQQTSSNWGYKSVPQKLSCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWA 163
            ...:...|.....||.|.::||   .| |::.....|||::.||:||:|.|:|.||:..|::.|.
Zfish    85 PAALTYNLCDDRYNWFYHTLPQ---AH-MDDRVMYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWQ 145

  Fly   164 AAGNPGWSYDEVLPYFLRSEHAQLQGLEQSPYHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPR 228
            :.|..||:||..||||.:   ||...|....|....|||.|...:.::.:..||::|..::|.|.
Zfish   146 SEGADGWNYDHCLPYFRK---AQTHELGPDRYRGGDGPLHVSRGKTQNPLHYAFIQAGQQAGYPY 207

  Fly   229 T-DYNGESQLGVSYVQANTLNGRRHSAYSAYIKPVRDLRSNLQIFTFSQVTRILIDEATKSAYGV 292
            | |.||..|.||.::......|:|.|..|||::|... |.||.......|||:|.|.|  .|.||
Zfish   208 TEDMNGFQQEGVGWMDMTIHKGQRWSTASAYLRPALS-RPNLSTEVRCMVTRVLFDGA--RARGV 269

  Fly   293 EFHYKNKAYTFKARKEVILSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCH 356
            |:....:.....|.||||||.|:.||||||:|||:|..|.|:.:.||:::.|| ||..:.||:
Zfish   270 EYQQNGQIKKVFAEKEVILSGGAINSPQLLLLSGVGNADELKTLDIPVVQHLPGVGCNLQDHL-- 332

  Fly   357 FGPTFVTNT-TGQTTFTSRVTPAELISFLL------AGNPATRMSSIGGVEALAFLKTQRSNLPN 414
              ..:|.:. |...|......|.:::...|      .|..||.....||     |::: |.::|:
Zfish   333 --ELYVQHACTQPITLYRAQKPLQMLKIGLEWLLKFTGYGATAHLESGG-----FIRS-RPDVPH 389

  Fly   415 DWPDIELIMVTGSLASDEGTGLKLGANFKDEIYDRMYRELAQAQQDHFTLLIMQFHPKSVGRLWL 479
              |||:...:...:........|:.|                     |.:.:......|||.|.|
Zfish   390 --PDIQFHFLPSQVIDHGRVSSKIEA---------------------FQVHVGPMRSTSVGWLKL 431

  Fly   480 KDRNPLGWPKIDPKYFVAEEDVEYLLDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGHQFASDD 544
            |.::|...|.:.|.|...|.||....:.::.:..|....|......   ....||......|..|
Zfish   432 KSKDPRDHPILQPNYLSTETDVLEFRECVRLTREIFAQQAFDEFRG---PEVQPGPAVQSDAEID 493

  Fly   545 YWRCSIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAF 609
            .:   :|..:.:.:|...||:||...|...||:.:|:|.||..|||||.|::|...:.:.||...
Zfish   494 AF---VRQKADSAYHPSCTCKMGRPEDRMAVVSPELRVFGVEGLRVVDASVMPSMVSGNLNAPTI 555

  Fly   610 MIGEKAADMIR 620
            ||.|||||.|:
Zfish   556 MIAEKAADAIK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	188/579 (32%)
		NADB_Rossmann	59..>90	CDD:304358	17/30 (57%)
		NADB_Rossmann	128..355	CDD:304358	91/228 (40%)
		GMC_oxred_C	471..615	CDD:282984	44/143 (31%)
chdh	XP_002663301.2	PRK02106	30..585	CDD:235000	191/590 (32%)
		NADB_Rossmann	38..>69	CDD:304358	19/30 (63%)
		GMC_oxred_N	110..333	CDD:279121	91/232 (39%)
		GMC_oxred_C	424..561	CDD:282984	44/142 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6434
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2314
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880