DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and MTMR6

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001372159.1	Gene:	MTMR6 / 9107	HGNCID:	7453	Length:	659	Species:	Homo sapiens

Alignment Length:	773	Identity:	168/773 - (21%)
Similarity:	276/773 - (35%)	Gaps:	260/773 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 NQAITAPL---------IDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGM 189
            |:::|..|         ||.:|:.|::..:        ||.::.:|....|.
Human    22 NKSLTGTLYLTATHLLFIDSHQKETWILHH--------HIASVEKLALTTSG------------- 65

  Fly   190 SRRKKLEPFKQQNISGRIAALHIVCKNFRLLKF----------------------------AF-- 224
                              ..|.|.|||||.:.|                            ||
Human    66 ------------------CPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSY 112

  Fly   225 --QQQDSKMFGASDQG-KLI--ASALVRFAYPMRH----DLSFAYA-----HREPYYSTLGAS-- 273
              :|.||:..    || :||  |....|...|..|    |.:..|.     .||.|...:.:.
Human   113 NPKQNDSERL----QGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPI 173

  Fly   274 --GTSMYATK----------NDWARELIRCGATEWQVVSCASVQLLQNP--LQAGKYTVPPHFVI 324
              |:|.:.:|          .|....:.||.    |.:|..|.:.|::.  |||          |
Human   174 IVGSSKFRSKGRFPVLSYYHQDKEAAICRCS----QPLSGFSARCLEDEHLLQA----------I 224

  Fly   325 PKSCSVDRFLDLSRAFCDSR-----AAFWVYSYGSSAALVRLAELQPAAQQDTK----SENVMLE 380
            .|:..|:|::.:    .|:|     .::|.........:||::.   ..|.|.|    :|...|.
Human   225 SKANPVNRYMYV----MDTRPKRRMQSWWATQKDIGRIIVRISS---KIQNDEKIRESNEKKRLN 282

  Fly   381 LVRKCDAGRQLKLLQLTDRLPSIQ---------DVLR-AYQKLRRLCTPETPEKFMLQDDKYLGL 435
            .:....||   |..:..|...:|:         .|:| :.|||..:    ...|.:..:|.|.|
Human   283 AMANRAAG---KGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEV----NGTKGLSVNDFYSG- 339

  Fly   436 LEKTNWLFYVSLCLRYASEASATLRSGVT-----CVLQESNGRDLCCVISSLAQLLLDPHFRTID 495
            ||.:.||.::...:    :|:..|...:|     .::..|:|.|....:.||..||||.::|||.
Human   340 LESSGWLRHIKAVM----DAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIK 400

  Fly   496 GFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEF 560
            ||..|::|:|::..|.|..|.|.: ...|         .|.||||..||:|||.|.:|||..|||
Human   401 GFMVLIEKDWISFGHKFSERCGQL-DGDP---------KEVSPVFTQFLECVWHLTEQFPQAFEF 455

  Fly   561 TQTYLTTLWDSCFMPIFDTFQFDTQAQR----LKAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPL 621
            ::.:|..:.:......|..|..:.|.:|    ||..|.|      :|    .|..:|:..:.|||
Human   456 SEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYS------LW----PFLLEDQKKYLNPL 510

  Fly   622 YQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYLQPAHRI 686
            |..:           :||.::                                     |:|....
Human   511 YSSE-----------SHRFTV-------------------------------------LEPNTVS 527

  Fly   687 FDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLPDAYYEFAGESR 751
            |:.:.|...|:::...|      .|:..:::  ::.|:.:..:.|:    .|:.|.      ||:
Human   528 FNFKFWRNMYHQFDRTL------HPRQSVFN--IIMNMNEQNKQLE----KDIKDL------ESK 574

  Fly   752 PNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGLTSVTGNLQLSTLSSFFPFGN 809
            ..|.|:::.|.....|.:..| ....|..|.:......|.:..|..|.|:....|..|
Human   575 IKQRKNKQTDGILTKELLHSV-HPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPADN 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	21/131 (16%)
		PTPc	<400..587	CDD:304379	60/201 (30%)
		3-PAP	<666..732	CDD:289355	8/65 (12%)
MTMR6	NP_001372159.1	PH-GRAM_MTMR6	1..101	CDD:270151	19/117 (16%)
MTMR6	NP_001372159.1	PTP_DSP_cys	130..469	CDD:421693	97/381 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740