Protein Alignment CG14411 and MTMR2

DIOPT Version :10

• Sequence 1: NP_572972.1
• Gene: CG14411 / 32408
• FlyBaseID: FBgn0030582
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_057240.3
• Gene: MTMR2 / 8898
• HGNCID: 7450
• Length: 643
• Species: Homo sapiens
• Alignment Length: 823
• Identity: 190/823 - (23%)
• Similarity: 309/823 - (37%)
• Gaps: 262/823 - (31%)

  Fly    15 SAGNADHHKRNTFTSYVAPLPGDLRATADTNEWCLPSDLRDV-------HLAKPRLLHGEQIVAS 72
            |:.:..|.:.:..|...:.:..|..:|:..|   ...|||.:       .:.:|.||.||.|...
Human    26 SSASTSHSENSVHTKSASVVSSDSISTSADN---FSPDLRVLRESNKLAEMEEPPLLPGENIKDM 87

  Fly    73 APAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKRNQAI 137
            |....|                  |...:|         |..|.|:|||::|.|..:.......:
Human    88 AKDVTY------------------ICPFTG---------AVRGTLTVTNYRLYFKSMERDPPFVL 125

  Fly   138 TAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQN 202
            .|.          ||    .:|.::      ::|.|:|     ||..|:
Human   126 DAS----------LG----VINRVE------KIGGASS-----RGENSY---------------- 149

  Fly   203 ISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLS-FAYAHREPY 266
                  .|..|||:.|.|:||.:.:....       :.|...|:::|:|:.::|. ||:.::|.:
Human   150 ------GLETVCKDIRNLRFAHKPEGRTR-------RSIFENLMKYAFPVSNNLPLFAFEYKEVF 201

  Fly   267 YSTLGASGTSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKY----TVPPHFVIPKS 327
                ..:|..:|....::.|:.|  ....|::.....           :|    |.|...|:|.:
Human   202 ----PENGWKLYDPLLEYRRQGI--PNESWRITKINE-----------RYELCDTYPALLVVPAN 249

  Fly   328 CSVDRFLDLSR-AFCDSRAAFWVYSY---GSSAALVRLAELQP---AAQQDTKSENVMLELVRKC 385
            ...:   :|.| |...||....|.|:   .|.|.:.|.:  ||   .:.:.:|.:...|:.:  .
Human   250 IPDE---ELKRVASFRSRGRIPVLSWIHPESQATITRCS--QPMVGVSGKRSKEDEKYLQAI--M 307

  Fly   386 DAGRQLKLLQLTDRLPSIQDVLR-----------AYQ--------------------KLRRLCTP 419
            |:..|...:.:.|..||:..|..           |||                    ||:.:..|
Human   308 DSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYP 372

  Fly   420 ETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQE-SNGRDLCCVISSLA 483
            .      :::..:|..||.|:||.::.|.|..|...:..:.||.|.|:.. |:|.|....::|||
Human   373 N------IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLA 431

  Fly   484 QLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVW 548
            .|:||.::|||.||:.||:|||::..|.||.|:||        |:....|:::|||||.|:||||
Human   432 MLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGH--------GDKNHADADRSPVFLQFIDCVW 488

  Fly   549 QLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDW-GEQFSDK 612
            |:.:|||..|||.:.:|.|:.|..:..:|.||..:::.||.|.....:.|  .:|.: ..|..|
Human   489 QMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTV--SLWSYINSQLED- 550

  Fly   613 DKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQD 677
                |:||||                      ||...|
Human   551 ----FTNPLY----------------------GSYSNH--------------------------- 562

  Fly   678 RYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLPDA 742
             .|.|...:..|::|...|.||.|.:      :||..:::|
Human   563 -VLYPVASMRHLELWVGYYIRWNPRM------KPQEPIHNR------------------------ 596

  Fly   743 YYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATP 785
            |.|...:....|.|.|:..:|.........||...| |:..||
Human   597 YKELLAKRAELQKKVEELQREISNRSTSSSERASSP-AQCVTP 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_572972.1	PH-like	<114..225	CDD:473070	25/110 (23%)
		PTP-MTMR10-like	343..549	CDD:350385	72/243 (30%)
MTMR2	NP_057240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		5/29 (17%)
		PH-like	73..187	CDD:473070	40/194 (21%)
		Myotub-related	202..528	CDD:461958	99/359 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..643		7/25 (28%)