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Protein Alignment CG14411 and MTMR2

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_057240.3	Gene:	MTMR2 / 8898	HGNCID:	7450	Length:	643	Species:	Homo sapiens

Alignment Length:	823	Identity:	190/823 - (23%)
Similarity:	309/823 - (37%)	Gaps:	262/823 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SAGNADHHKRNTFTSYVAPLPGDLRATADTNEWCLPSDLRDV-------HLAKPRLLHGEQIVAS 72
            |:.:..|.:.:..|...:.:..|..:|:..|   ...|||.:       .:.:|.||.||.|...
Human    26 SSASTSHSENSVHTKSASVVSSDSISTSADN---FSPDLRVLRESNKLAEMEEPPLLPGENIKDM 87

  Fly    73 APAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKRNQAI 137
            |....|                  |...:|         |..|.|:|||::|.|..:.......:
Human    88 AKDVTY------------------ICPFTG---------AVRGTLTVTNYRLYFKSMERDPPFVL 125

  Fly   138 TAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQN 202
            .|.          ||    .:|.::      ::|.|:|     ||..|:
Human   126 DAS----------LG----VINRVE------KIGGASS-----RGENSY---------------- 149

  Fly   203 ISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLS-FAYAHREPY 266
                  .|..|||:.|.|:||.:.:....       :.|...|:::|:|:.::|. ||:.::|.:
Human   150 ------GLETVCKDIRNLRFAHKPEGRTR-------RSIFENLMKYAFPVSNNLPLFAFEYKEVF 201

  Fly   267 YSTLGASGTSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKY----TVPPHFVIPKS 327
                ..:|..:|....::.|:.|  ....|::.....           :|    |.|...|:|.:
Human   202 ----PENGWKLYDPLLEYRRQGI--PNESWRITKINE-----------RYELCDTYPALLVVPAN 249

  Fly   328 CSVDRFLDLSR-AFCDSRAAFWVYSY---GSSAALVRLAELQP---AAQQDTKSENVMLELVRKC 385
            ...:   :|.| |...||....|.|:   .|.|.:.|.:  ||   .:.:.:|.:...|:.:  .
Human   250 IPDE---ELKRVASFRSRGRIPVLSWIHPESQATITRCS--QPMVGVSGKRSKEDEKYLQAI--M 307

  Fly   386 DAGRQLKLLQLTDRLPSIQDVLR-----------AYQ--------------------KLRRLCTP 419
            |:..|...:.:.|..||:..|..           |||                    ||:.:..|
Human   308 DSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYP 372

  Fly   420 ETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQE-SNGRDLCCVISSLA 483
            .      :::..:|..||.|:||.::.|.|..|...:..:.||.|.|:.. |:|.|....::|||
Human   373 N------IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLA 431

  Fly   484 QLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVW 548
            .|:||.::|||.||:.||:|||::..|.||.|:||        |:....|:::|||||.|:||||
Human   432 MLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGH--------GDKNHADADRSPVFLQFIDCVW 488

  Fly   549 QLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDW-GEQFSDK 612
            |:.:|||..|||.:.:|.|:.|..:..:|.||..:::.||.|.....:.|  .:|.: ..|..|
Human   489 QMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTV--SLWSYINSQLED- 550

  Fly   613 DKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQD 677
                |:||||                      ||...|
Human   551 ----FTNPLY----------------------GSYSNH--------------------------- 562

  Fly   678 RYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLPDA 742
             .|.|...:..|::|...|.||.|.:      :||..:::|
Human   563 -VLYPVASMRHLELWVGYYIRWNPRM------KPQEPIHNR------------------------ 596

  Fly   743 YYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATP 785
            |.|...:....|.|.|:..:|.........||...| |:..||
Human   597 YKELLAKRAELQKKVEELQREISNRSTSSSERASSP-AQCVTP 638

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.