DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Sbf1

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006521601.1	Gene:	Sbf1 / 77980	MGIID:	1925230	Length:	1901	Species:	Mus musculus

Alignment Length:	887	Identity:	202/887 - (22%)
Similarity:	297/887 - (33%)	Gaps:	290/887 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PLPGDLRATADTNEWCLPSDLRDVHLAKPRLLHGEQIVASAPAYMYSPIDPMDSSG--------- 88
            |.|.|.......:|...||.|                   .|:....|.|.|..|.
Mouse  1092 PPPEDQEDEISVSEELEPSTL-------------------TPSSALKPSDRMTMSSLVERACCRD 1137

  Fly    89 ----GSGSTLSAISSASGTPADRHHKEATFGLLSVTNF--------KLAFVPLHEKRNQAITAPL 141
                |.|:..|::|.|...|         |.:..|...        .|..||      |:|
Mouse  1138 YQRLGLGTLSSSLSRAKSEP---------FRISPVNRMYAICRSYPGLLIVP------QSI---- 1183

  Fly   142 IDLYQENTYLGRNEITLNNIDHIYTITEL-------GRAASALQAARGMASH--AGMSRRKKLEP 197
                |:|        .|..:...|.....       ||:.:.|..:.|:...  .|:
Mouse  1184 ----QDN--------ALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGL-------- 1228

  Fly   198 FKQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPM-RHDL-SFAY 260
            ||.||......|                |.||.........:.:.|::.|:|... |:.| ||:.
Mouse  1229 FKAQNTPSPGQA----------------QADSSSLEQEKYLQAVVSSMPRYADSSGRNTLSSFSS 1277

  Fly   261 AHREPYY-----------STLGASGTSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAG 314
            ||...:.           :.|.||.:...|::..|:.  :|.......:.|....:|....|.:.
Mouse  1278 AHMGGHVPSPRARVTTLSNPLAASASRWTASRGKWSS--VRASGRSSGLGSDVGSRLAGRDLLST 1340

  Fly   315 KYT--VPPH--FVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAAL--VRLAELQPAAQQDTK 373
            .:|  .||.  |:.|:                 |||  :|..|..|.|  ||...||       :
Mouse  1341 PHTNGAPPDSGFLRPQ-----------------RAA--LYIIGDKAQLKGVRPDPLQ-------Q 1379

  Fly   374 SENVMLELVRKCDAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEK 438
            .|.|.:|:..    .||:|               .:::||.:.|.|..|.. ......:|..||.
Mouse  1380 WELVPIEVFE----ARQVK---------------ASFKKLLKACVPGCPAT-EPSPASFLRSLED 1424

  Fly   439 TNWLFYVSLCLRYASEASATLRSGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQK 503
            :.||..:...|:.:......|.||.:.::...:|.|:...:.||.|||.||.:||::||:.||:|
Mouse  1425 SEWLIQIHKLLQISVLVVELLDSGSSVLVSLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEK 1489

  Fly   504 EWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTL 568
            ||::..|.|..|..|....|.:|         .:||||.|||||.|:..|||.||||:|.||..|
Mouse  1490 EWLSFGHRFSHRGAHTLAGQSSG---------FTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFL 1545

  Fly   569 WDSCFMPIFDTFQFDTQAQRL--------KAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPLYQRQ 625
            ........|.||..|:..:|:        |.....||..:.||::.::.|.:..||: |..|
Mouse  1546 GYHHTSRRFRTFLLDSDYERIELGLLYEEKGERRGQLACKSVWEYVDRLSKRTPMFY-NYTY--- 1606

  Fly   626 RGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQD-RYLQPAHRIFDL 689
                                                            .|:| ..|:|...:.:|
Mouse  1607 ------------------------------------------------APEDTEVLRPYSNVSNL 1623

  Fly   690 QVWDQCY----------YRW--------LPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNF 736
            :||| .|          |.|        .|..:...||.||         |....|..|.|.:..
Mouse  1624 KVWD-FYTEETLAEGPPYDWELAQGPPEPPEEERPDGGAPQ---------SRRRVVWPCYDSRPR 1678

  Fly   737 DDLPDAYYEFAGE--------SRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGLTSVT 793
            .. |||......|        .||::...:..|:...|:.::..:..|      .||:|.|.|..
Mouse  1679 VQ-PDAISRLLEELQRLETELGRPSERWKDTWDRVKAAQRLESRQDGR------GTPSSLLVSAV 1736

  Fly   794 GNLQLSTLSSFFPFGNPIAGDAPLQLYDILSSSSELLMETSS 835
            .:.:.| |..:...| |:.....|.|....||.|    .|||
Mouse  1737 PHHRRS-LGVYLQEG-PVGSTLSLSLDSDQSSGS----TTSS 1772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	21/127 (17%)
		PTPc	<400..587	CDD:304379	63/186 (34%)
		3-PAP	<666..732	CDD:289355	19/84 (23%)
Sbf1	XP_006521601.1	uDENN	1..86	CDD:214824
		DENN	129..318	CDD:214823
		dDENN	372..440	CDD:129037
		SBF2	551..772	CDD:372054
		PH-like	901..1019	CDD:388408
		PTP_DSP_cys	1158..1530	CDD:391942	112/474 (24%)
		PH_Sbf1_hMTMR5	1794..1899	CDD:269941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840