DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Sbf2

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_008758019.1	Gene:	Sbf2 / 691042	RGDID:	1588657	Length:	1904	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	204/961 - (21%)
Similarity:	310/961 - (32%)	Gaps:	373/961 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LAKPRLLHGEQIVASAPAYMYSPIDPMDSSGG--SGSTLSAISSA----------SGTPADRHHK 110
            :.:|.||.||:||......:..|....:::||  .|..|.....|          .|||.|:...
  Rat   871 ILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVG 935

  Fly   111 EAT----FGLLSVTN---------------------------FKLAF--------VPLHEKR--- 133
            |.|    |.:.|:|.                           .|:||        |.:.:|:
  Rat   936 EQTVVRSFPIASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVDIFKKQLMK 1000

  Fly   134 ---NQAI----------TAPLIDL---YQENT------------------------YL------- 151
               .|:|          |.|.|.|   .::||                        ||
  Rat  1001 FRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKKAGKMTIGRQYLLKKRTGT 1065

  Fly   152 ---------GRNE---ITLNNIDHIYTITELGRAASALQ------------AARGMASHAGMSRR 192
                     |.||   |::::...:.|.|.|..:..:..            ...|:.:.:|.|.|
  Rat  1066 IVEERANRPGWNEEDDISVSDDCELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSR 1130

  Fly   193 KKLEPFKQQNISGRIAA---LHIVCKNF-RLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMR 253
            .|.|.|       |:.|   |:.:|::: .||......||              |:|.|.|...|
  Rat  1131 SKPEYF-------RVTASNRLYSLCRSYPGLLVIPQAVQD--------------SSLPRVARCYR 1174

  Fly   254 HDLSFAYAHREPYYSTL--------GASGTSMYATKNDWARELIRCGATEWQVVSCASVQ----- 305
            |:.......:.....||        |.....::.::|            ..|.||.:|::
  Rat  1175 HNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQN------------SPQAVSTSSLESSSSI 1227

  Fly   306 ------------------------LLQNP---LQAG------------KYTVPPHFVIPKSCSVD 331
                                    |...|   |..|            |..||.|..:..|.|..
  Rat  1228 EQEKYLQALLTAVIVHQKLRGNSTLTVRPTLALSPGTERRSSRMSTVLKQVVPGHLDVNPSNSFA 1292

  Fly   332 RFLDLSRAFCDSRA-------------AFWVYSYGSSAALV-----------RLAELQPAA--QQ 370
            |.:...|..|.:::             ..|. |..||..|:           |||....:|  ..
  Rat  1293 RGVHGYRDKCFTQSNSKSSAKEPVHNQGVWA-SLRSSTRLISSPTSLIDVGARLAGKDHSASFSN 1356

  Fly   371 DTKSENVMLELVRKCDAGRQLKLLQLTDR----------------LP----SIQDVLRAYQKLRR 415
            .|..:|.:        :.||..|....::                :|    .|:.|..:::||.|
  Rat  1357 STYLQNQL--------SKRQAALYIFGEKSQLRSSKVEFAFNCEFVPVEFHEIRQVKASFKKLMR 1413

  Fly   416 LCTPETPEKFMLQDDK---YLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQESNGRDLCC 477
            .|.|.|     :..|.   :|..||.:.|...:...::.|...|..|.:|.:..:....|.|:..
  Rat  1414 ACIPST-----IPTDSEVTFLKALEDSEWFPQLHRIMQLAVVVSEVLENGSSVWVCLEEGWDITT 1473

  Fly   478 VISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLL 542
            .::||.|||.||.:|||:||:.||:|||::..|.|.:|......:|.:|         .:|:||.
  Rat  1474 QVTSLVQLLSDPFYRTIEGFRMLVEKEWLSFGHKFSQRSSLALNSQGSG---------FAPIFLQ 1529

  Fly   543 FLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGE 607
            |||||.|:..|:|.||||...||..|........|.||..|:..:||              :.|.
  Rat  1530 FLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERL--------------EHGT 1580

  Fly   608 QFSDK-DKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATA 671
            .|.|| ||        ..::|....:.....|:||                       |..|...
  Rat  1581 LFDDKGDK--------HAKKGVCIWECIDKMHKRS-----------------------PVFFNYL 1614

  Fly   672 SSVPQDRYLQPAHRIFDLQVWDQCYYR-----------WLPIL---------DIRGGGQPQVDLY 716
            .|..:...|:|...:..|:.||  ||.           |:.:.         |:.||..||
  Rat  1615 YSPVEIEALKPNVNVSSLKKWD--YYTEETLSAGPSYDWMMLTPKHFPYEESDVAGGAGPQ---- 1673

  Fly   717 HRLLLSNIAKVQRCLDYQNFDDL----PDAYYEFAGESRPNQHK-DEKPDK 762
                      .||...:..:||:    |||......|....:|| ::.|:|
  Rat  1674 ----------SQRKTVWPCYDDVTCSQPDALTRLFSEIEKLEHKLNQTPEK 1714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	38/223 (17%)
		PTPc	<400..587	CDD:304379	64/193 (33%)
		3-PAP	<666..732	CDD:289355	17/85 (20%)
Sbf2	XP_008758019.1	uDENN	1..86	CDD:214824
		DENN	115..297	CDD:280329
		dDENN	351..419	CDD:129037
		SBF2	530..752	CDD:289132
		PH-GRAM_MTMR13	880..998	CDD:275416	23/117 (20%)
		Myotub-related	1114..1574	CDD:284109	120/515 (23%)
		PH_Sbf1_hMTMR5	1797..1902	CDD:269941
		PH	1802..1902	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840