DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Mtmr11

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001178025.1	Gene:	Mtmr11 / 689613	RGDID:	1589965	Length:	700	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	218/784 - (27%)
Similarity:	316/784 - (40%)	Gaps:	213/784 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGAGSAGNADHHKRNTFTSYVAPL--PGDLRATADTNEW--CLPSDLRDVHLAKPRLLHGEQIVA 71
            ||.|.:.|....|......:..|.  ||:......:::.  ||.|.          .|.||.|:|
  Rat     4 GGRGQSFNIAPQKEEPELGFSGPKSDPGNRMPEPSSHQLGSCLASG----------CLPGEHILA 58

  Fly    72 SAPAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKRNQA 136
            .||.....|          |..|.                   |.|..|||::.|.|...:|||
  Rat    59 WAPGRRKGP----------GLELP-------------------GTLICTNFRVTFQPCGWQRNQ- 93

  Fly   137 ITAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQ 201
             ..||...|.                  :.:..:||    |:|.      :|:||.:.|.|..|.
  Rat    94 -DTPLSSEYD------------------FALINIGR----LEAV------SGLSRVQLLRPGSQL 129

  Fly   202 NISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLSFAYAHREPY 266
            ........:|  .::||||:..|:..     |.:.|...:..|:::    .|...|....:|...
  Rat   130 KFIPEEVLIH--GRDFRLLRIGFEAG-----GLAPQAFQVTMAIIQ----ARAQSSQVQQYRGIT 183

  Fly   267 YSTLG-ASGT-----SMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKYTVPPHFVIP 325
            .|..| .||:     .:..|..||..|..:.||..|: ||..:.:.......:|.:.||
  Rat   184 LSKAGKVSGSRKPPIPLLETLEDWETERKKQGARGWR-VSMVNERFDVATSLSGYFWVP------ 241

  Fly   326 KSCSVDRFLD--LSRAFCDSRAAF---------WVYSYGSSAALVRLAELQPAA---QQDTKSEN 376
                 :|.||  :.|||    |.|         |.:..||.  |:|.|....|:   ::|.::..
  Rat   242 -----NRILDSEVRRAF----AHFHQGRGPRLSWHHPGGSD--LLRCAGFYIASDPNKEDIRAVE 295

  Fly   377 VMLELVRKCDAGR-QLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTN 440
            :||:      ||. .:.|:...|.:||:.||..|:.|||.||.|::    .:.:||:|..||.|.
  Rat   296 LMLQ------AGHSDVVLVDTMDEMPSLADVQLAHLKLRALCLPDS----SVAEDKWLSALEGTR 350

  Fly   441 WLFYVSLCLRYASEASATLRSGV-TCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKE 504
            ||.||..|||.||:.|..:.|.| :.||||...||...::|||.||||.|..||:.|||||||:|
  Rat   351 WLDYVRSCLRKASDISVLVTSRVRSVVLQERGDRDFNGLLSSLVQLLLAPEARTLFGFQSLVQRE 415

  Fly   505 WVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLW 569
            |||..|||..|||            |...||::||..|||||.||||||||.||||::.:|..|.
  Rat   416 WVAAGHPFLTRLG------------ETGASEEAPVLPLFLDCAWQLLQQFPAEFEFSEFFLLALH 468

  Fly   570 DSCFMPIFDTF-------------QFDTQAQRLKAVTDSQLVLRP------VWDWGEQFSDKDKM 615
            ||..:|...||             ||::..|.........|...|      ||||..::|.:...
  Rat   469 DSIRVPDTLTFLRNTPWERGKKSGQFNSYTQVYTPEYSQPLAGSPANLHLSVWDWDLRYSKEQIS 533

  Fly   616 FFSNPLYQ----------RQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTIN------ 664
            .|.||.|.          ||:..|....:.    .|:.:.|:||....:.:.|.:::.:
  Rat   534 QFLNPGYDPEHCPDSGLPRQQPSLMVPGSP----SSMWLFSRGALTPLNQLCPWQDSTSLLTVSS 594

  Fly   665 ---PQLFATASSVPQDRY---------------LQPAHRIFDLQVWDQCYYRWLPILDIRGGGQP 711
               |:...::.|:....:               |.|.:....::.|.:||.|          |:|
  Rat   595 HWLPRPARSSESLADQEWGLPSHWGACPLPPGLLLPGYLGPQIRFWKRCYLR----------GRP 649

  Fly   712 QVDL 715
            :|.:
  Rat   650 EVQI 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	28/110 (25%)
		PTPc	<400..587	CDD:304379	93/200 (47%)
		3-PAP	<666..732	CDD:289355	10/65 (15%)
Mtmr11	NP_001178025.1	PH-like	51..165	CDD:302622	41/179 (23%)
		PTPc	195..469	CDD:304379	120/313 (38%)
		3-PAP	553..683	CDD:289355	18/115 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349528
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810