DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and SBF1

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_011529011.1	Gene:	SBF1 / 6305	HGNCID:	10542	Length:	1903	Species:	Homo sapiens

Alignment Length:	1013	Identity:	218/1013 - (21%)
Similarity:	322/1013 - (31%)	Gaps:	379/1013 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LAKPRLLHGEQIVASAPAYMYSPIDPMDSSGGSGSTLSAISSASG-------------------- 102
            |.:||||.||:.|.........|....:.:|||... .|:..|.|
Human   894 LLRPRLLPGEECVLDGLRVYLLPDGREEGAGGSAGG-PALLPAEGAVFLTTYRVIFTGMPTDPLV 957

  Fly   103 -----------------------TPADR------HHKEATFGLLSVTNFKLAF------------ 126
                                   ||.|:      ..:..||.||     |:||
Human   958 GEQVVVRSFPVAALTKEKRISVQTPVDQLLQDGLQLRSCTFQLL-----KMAFDEEVGSDSAELF 1017

  Fly   127 -VPLHEKR-------------NQAIT-----------APLIDLYQENTY------LGRNEITLNN 160
             ..||:.|             ..|.|           .|.:.....|..      :||..:|...
Human  1018 RKQLHKLRYPPDIRATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKKTIGRQHVTRKK 1082

  Fly   161 I-----------------DHIYTITELGRA----ASALQAARGMASHAGMSR------------- 191
            .                 |.|....||..:    :|||:.:..|...:.:.|
Human  1083 YNPPSWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGT 1147

  Fly   192 ------RKKLEPFKQQNISGRIA------------------ALHIVCKNFRLLKF---------- 222
                  |.|.|||:...::...|                  ||..|.:.:|..:|
Human  1148 LSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRS 1212

  Fly   223 -----------------AFQQQDSKMFGAS--DQGKL--------IASALVRFAYPM-RHDLS-F 258
                             .|:.|::...|.|  |...|        :.|::.|:|... |:.|| |
Human  1213 KAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGF 1277

  Fly   259 AYAHREPYY-----------STLGASGTSMYATKNDW--ARELIRCGATEWQVVSCASVQLLQNP 310
            :.||...:.           :.:.||.:...|.:..|  .|...|.......|.|..:.:....|
Human  1278 SSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDVGSRLAGRDALAP 1342

  Fly   311 LQAGKYTVPPHFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAAL--VRLAELQPAAQQDTK 373
            .||......|.|:.|:                 |||  :|..|..|.|  ||...||       :
Human  1343 PQANGGPPDPGFLRPQ-----------------RAA--LYILGDKAQLKGVRSDPLQ-------Q 1381

  Fly   374 SENVMLELVRKCDAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEK 438
            .|.|.:|:..    .||:|               .:::||.:.|.|..|.. ......:|..||.
Human  1382 WELVPIEVFE----ARQVK---------------ASFKKLLKACVPGCPAA-EPSPASFLRSLED 1426

  Fly   439 TNWLFYVSLCLRYASEASATLRSGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQK 503
            :.||..:...|:.:......|.||.:.::...:|.|:...:.||.|||.||.:||::||:.||:|
Human  1427 SEWLIQIHKLLQVSVLVVELLDSGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEK 1491

  Fly   504 EWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTL 568
            ||::..|.|..|..|....|.:|         .:||||.|||||.|:..|||.||||:|.||..|
Human  1492 EWLSFGHRFSHRGAHTLAGQSSG---------FTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFL 1547

  Fly   569 WDSCFMPIFDTFQFDTQAQRL--------KAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPLYQRQ 625
            ........|.||..|:..:|:        |.....|:..|.||::.::.|.:..: |.|.:|
Human  1548 GYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPV-FHNYMY--- 1608

  Fly   626 RGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQD-RYLQPAHRIFDL 689
                                                            .|:| ..|:|...:.:|
Human  1609 ------------------------------------------------APEDAEVLRPYSNVSNL 1625

  Fly   690 QVWDQCY----------YRW--------LPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLD---- 732
            :||| .|          |.|        .|..:...||.||         |....|..|.|
Human  1626 KVWD-FYTEETLAEGPPYDWELAQGPPEPPEEERSDGGAPQ---------SRRRVVWPCYDSCPR 1680

  Fly   733 YQNFDDLPDAYYEFAGE--------SRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGL 789
            .|     |||......|        .:|.:...:..|:...|:.::|     :|..: .||:|.|
Human  1681 AQ-----PDAISRLLEELQRLETELGQPAERWKDTWDRVKAAQRLEG-----RPDGR-GTPSSLL 1734

  Fly   790 TSVTGNLQLSTLSSFFPFGNPIAGDAPLQLYDILSSSS 827
            .|...:.:.| |..:...| |:.....|.|....||.|
Human  1735 VSTAPHHRRS-LGVYLQEG-PVGSTLSLSLDSDQSSGS 1770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	36/238 (15%)
		PTPc	<400..587	CDD:304379	63/186 (34%)
		3-PAP	<666..732	CDD:289355	19/84 (23%)
SBF1	XP_011529011.1	uDENN	36..92	CDD:281455
		DENN	139..320	CDD:214823
		dDENN	374..442	CDD:129037
		SBF2	553..774	CDD:289132
		PH-GRAM_MTMR5	903..1021	CDD:275417	19/123 (15%)
		Myotub-related	1138..1566	CDD:284109	120/482 (25%)
		PH_Sbf1_hMTMR5	1796..1901	CDD:269941
		PH	1800..1901	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840