DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and mtmr9

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001038535.1	Gene:	mtmr9 / 565063	ZFINID:	ZDB-GENE-040724-223	Length:	549	Species:	Danio rerio

Alignment Length:	580	Identity:	131/580 - (22%)
Similarity:	226/580 - (38%)	Gaps:	132/580 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 QQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLSFAYAHRE 264
            ::...|.:..:.:.||:.|:::......:..:..||....|.....|...||      |.|   .
Zfish    59 EKRFVGSLGTIIVKCKDLRVIQLDIPGMEECLNIASSVEALSTLDSVSLMYP------FFY---R 114

  Fly   265 PYYSTLGASGTSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGK-YTVPPHFVIPKSC 328
            |.:..: ..|..::..:.  |.:.:.....||::            .:..| ::|.|.:  |...
Zfish   115 PLFEVI-EDGWQLFVPEE--AFKDLESMTDEWRL------------SEVNKDFSVCPSY--PSLL 162

  Fly   329 SVDRFLD----LSRAFCDSRAAFWVYS-YGSSAALVRLAELQP-------AAQQDTKSENVMLEL 381
            :|.:.:|    :..|.......|.|.| |.....:|.:...||       ..::|.|..|..|..
Zfish   163 TVPKDIDDESLIKAASFRHGGRFPVLSYYHKKNGMVMMRAAQPLTGTNGRRCKEDEKLINATLCA 227

  Fly   382 --------VRKCDAGRQLKL----LQLTDRLPSIQDVLRAYQ----------KLRRLCTPETPEK 424
                    .|.....:|.|.    .:.....|..:.:.:|.:          ||...|..::...
Zfish   228 GKRGYIIDTRTIAVAQQAKARGGGFEQEANYPQWRRIHKAIERSNILQESLIKLVEACNDQSHNM 292

  Fly   425 FMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATL-RSGVTCVLQESNGRDLCCVISSLAQLLLD 488
                 |::|..||.:||..:|...|..|..|:..: |.|.:.::..|.|.|....::||||::||
Zfish   293 -----DRWLSKLEASNWQSHVKEILTTACLAAQCIDREGASVLVHGSEGTDSTLQVTSLAQIILD 352

  Fly   489 PHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQ 553
            |..|||.||::|:::||:...||||:|.     ||.|..|.:  ...::||||||||||||:|:|
Zfish   353 PACRTIRGFEALIEREWLQAGHPFQQRC-----AQSAYSNGK--PRSEAPVFLLFLDCVWQILRQ 410

  Fly   554 FPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFFS 618
            ||..|:|::::|..|::..:...|.||..::.|:|.|.....:.|  .:|.|..:..:.::  :.
Zfish   411 FPCSFQFSESFLIMLFEHTYASQFGTFLGNSVAERAKLQLSHKTV--SLWSWVNRPQELER--YL 471

  Fly   619 NPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYLQPA 683
            ||||:..                                        .|....|..||
Zfish   472 NPLYEAN----------------------------------------NLVIWPSVAPQ------- 489

  Fly   684 HRIFDLQVWDQCYYRW---LPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLP 740
                .|.:|:..:.||   ...||........:..|::.|.:.:..::|.|.....:|.|
Zfish   490 ----SLLLWEGVFLRWNRSTKCLDEAYQEMVHIIEYNKELQNKVNSLRRQLAQLETEDSP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	4/24 (17%)
		PTPc	<400..587	CDD:304379	67/197 (34%)
		3-PAP	<666..732	CDD:289355	13/68 (19%)
mtmr9	NP_001038535.1	PH-GRAM_MTMR9	1..97	CDD:275398	6/37 (16%)
mtmr9	NP_001038535.1	Myotub-related	108..444	CDD:284109	97/373 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840