DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and mtm1

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001032773.2	Gene:	mtm1 / 560881	ZFINID:	ZDB-GENE-051113-128	Length:	639	Species:	Danio rerio

Alignment Length:	744	Identity:	171/744 - (22%)
Similarity:	289/744 - (38%)	Gaps:	202/744 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IVASAP--AYMYSPIDPMDSSGGSGSTLSAISSASGT--PADRH-----------HKEATFGLLS 118
            ::||||  .|..||:....|...|..:|.....|..|  |.:..           :..|..|.:.
Zfish    33 VMASAPIAPYNSSPLGNSSSQNASRESLKMEPLADVTLLPGEERVIDKDIIYICPYNAAVKGKVF 97

  Fly   119 VTNFKLAFVPLHEKRNQAITAPLIDLYQENTYLGRNEITLN-NIDHIYTITELGRAASALQAARG 182
            :||::|.|      :|.....|               :||| .:..|..:.::|.|:|     ||
Zfish    98 ITNYRLYF------KNTDSETP---------------VTLNIPLGVISRVEKMGGASS-----RG 136

  Fly   183 MASHAGMSRRKKLEPFKQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVR 247
            ..|:                      .|.|.||:.|.|:||.:|:     |.|.:.  |...:.:
Zfish   137 ENSY----------------------GLEITCKDMRNLRFALKQE-----GHSRRD--IFEIIFK 172

  Fly   248 FAYPMRHDLS-FAYAHREPYYSTLGASGTSMYATKNDWARELIRCGATEWQVVSC-ASVQLLQNP 310
            :|:|:.|.:. ||:..:|.|..    :|.::|....::.|:.:  ...||:|... .:.:|..
Zfish   173 YAFPLSHGMQLFAFLSQEKYEE----NGWNVYEALEEYRRQGL--PNNEWRVTFINKNYELCD-- 229

  Fly   311 LQAGKYTVPPHFVIPKSCSVD--RFLDLSRAFCDSRAAFWVYSYGSSAALVRLAE-LQPAAQQDT 372
                  |.|...|:|...:.|  |.:...|:.|......|.:. .:.|.:.|.:: |...:.:..
Zfish   230 ------TYPTILVVPYKATEDDLRKVATFRSRCRIPVMSWFHK-ENHAVITRCSQPLVGMSGKRN 287

  Fly   373 KSENVMLELVRKCDAGRQLKLLQLTDRLPSIQDVLR-----------AYQ--------------- 411
            |.:...|:|:|:.:...:|.:.   |..|::..|..           |||
Zfish   288 KDDERYLDLIREANGTTKLTIY---DARPNVNAVANKATGGGYEGDDAYQNAELVFLDIHNIHVM 349

  Fly   412 -----KLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQESN 471
                 ||:.:..|.      :::..:|..||.|:||.::.|.|..|.:.:..:.||.:.::..|:
Zfish   350 RESLKKLKDIVYPN------VEESHWLSSLESTHWLEHIKLVLSGAIQVADKVSSGSSVMVHCSD 408

  Fly   472 GRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQ 536
            |.|....::||:.|:||.::||:.|||.|::|||::..|.|..|:||        |:....|.::
Zfish   409 GWDRTAQLTSLSMLMLDSYYRTLRGFQVLMEKEWISFGHKFASRIGH--------GDKNHADQDR 465

  Fly   537 SPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLV-LR 600
            ||:||.|:|||||:.:|||..|||.:..|..:.|..:...|.||.::.:     :|.||..| .:
Zfish   466 SPIFLQFIDCVWQMTKQFPTAFEFNERLLVVILDHLYSCRFGTFLYNCE-----SVRDSNNVRTK 525

  Fly   601 PVWDWGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINP 665
            .|..|  .:.:.|...:.||.|                                  ||.
Zfish   526 TVSLW--SYINSDTSLYINPFY----------------------------------TPE------ 548

  Fly   666 QLFATASSVPQDRYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRC 730
                      ..|.|.|...:..|::|...|.||.|.:. .....|....|..||......:::.
Zfish   549 ----------SSRVLYPVASMRHLELWVTYYIRWNPRIQ-HQQQSPVEQRYKELLALRDQYLKKL 602

  Fly   731 LDYQNFDDLPDAYY----EFAGESRPNQH 755
            .:.|..|..|.:.:    .....:.||||
Zfish   603 EELQLSDSAPSSTHLTNSSTPNAATPNQH 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	25/111 (23%)
		PTPc	<400..587	CDD:304379	64/217 (29%)
		3-PAP	<666..732	CDD:289355	13/65 (20%)
mtm1	NP_001032773.2	PH-like	77..176	CDD:327399	31/153 (20%)
mtm1	NP_001032773.2	Myotub-related	199..517	CDD:310891	88/350 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840