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Protein Alignment CG14411 and MTMR8

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_060147.2	Gene:	MTMR8 / 55613	HGNCID:	16825	Length:	704	Species:	Homo sapiens

Alignment Length:	727	Identity:	161/727 - (22%)
Similarity:	273/727 - (37%)	Gaps:	212/727 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 ITAP------LIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKL 195
            ||.|      |:|.|....  ..|.|......|:..:    .|:.|.:....:|.|       .:
Human     4 ITVPKVENVKLVDRYVSKK--PANGILYLTATHLIYV----EASGAARKETWIALH-------HI 55

  Fly   196 EPFKQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLSFAY 260
            ...::..|:.....|.:.|||||:..|..   ||.:....     :..:|::.:.|...:..:|:
Human    56 ATVEKLPITSLGCPLTLRCKNFRVAHFVL---DSDLVCHE-----VYISLLKLSQPALPEDLYAF 112

  Fly   261 AHREPYYSTLGASGTSMYATKNDWARELIRCGATEWQVVS-------CASVQLLQNPLQAGKYTV 318
            ::.......:..||..:....:|:.|  :......|.:..       |:              |.
Human   113 SYNPKSSKEMRESGWKLIDPISDFGR--MGIPNRNWTITDANRNYEICS--------------TY 161

  Fly   319 PPHFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSY-GSSAALVRLAELQPAAQQDTK--SENVMLE 380
            ||..|:|||.::...:..|:.....|.....|.| .::||:.|.:  ||.:...|:  .:.::||
Human   162 PPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCS--QPLSGFYTRCVDDELLLE 224

  Fly   381 LVRKCDAGRQL--------KLLQLTDR---------------------LPSIQDVLRAYQKLRRL 416
            .:.:.:.|.|.        ||..:.:|                     :.:|..:..:.|||..:
Human   225 AISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEV 289

  Fly   417 CTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLR---YASEASATLRSGVTCVLQESNGRDLCCV 478
            |..:||..     .::|..||.:.||.::...:.   :.::|....::.|  ::..|:|.|....
Human   290 CELKTPTM-----SEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASV--LVHCSDGWDRTAQ 347

  Fly   479 ISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLF 543
            :.|:|.:||||.:||..|...|::|||:::.|.|.:|.||:      .|:::    |.||:|..|
Human   348 VCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHL------DGDSK----EVSPIFTQF 402

  Fly   544 LDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTF----QFDTQAQRLKAVTDSQLVLRPVWD 604
            |||:|||::|||..|||.:.:|..:.|..|...|..|    |.|.:..|:...|.|      ||
Human   403 LDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHS------VW- 460

  Fly   605 WGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFA 669
               .|..:.|..|.||||:                               |.| ....:||
Human   461 ---PFLVQRKPDFRNPLYK-------------------------------GFT-MYGVLNP---- 486

  Fly   670 TASSVPQDRYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQ 734
              |:||           :::|.|...|.|:      ..|.||:..:...||  .|.|.:..|:
Human   487 --STVP-----------YNIQFWCGMYNRF------DKGLQPKQSMLESLL--EIKKQRAMLE-- 528

  Fly   735 NFDDLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGLTSVTGNLQLS 799
                             .:.|:.||.           ::.|.:|..:..|     .|..||:...
Human   529 -----------------TDVHELEKK-----------LKVRDEPPEEICT-----CSQLGNILSQ 560

  Fly   800 TLSSFFPFGNPI 811
            .|.|  |..||:
Human   561 HLGS--PLTNPL 570

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.