DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and mtmr10

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_005168938.1	Gene:	mtmr10 / 555239	ZFINID:	ZDB-GENE-061103-52	Length:	765	Species:	Danio rerio

Alignment Length:	812	Identity:	230/812 - (28%)
Similarity:	353/812 - (43%)	Gaps:	190/812 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TFTSYVAPLPGDLRATADTNEWCLPSDLRDVHLAKPRLLHGEQIVASAPAYMYSPIDPMDSSGGS 90
            ||.||:.||..||:.:..     ||     :...:.:||.||.:|..|
Zfish    10 TFKSYLPPLQTDLKKSPQ-----LP-----IKKLEAKLLPGEIVVNEA----------------- 47

  Fly    91 GSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFV---PLHEKRNQAITAPLIDLYQENTYLG 152
            ......|.:.||       ::..:|.|..||||::|:   .|.::|.|.          .:..||
Zfish    48 NFVRKCIGADSG-------QDDLWGKLVCTNFKVSFISHNSLPQQRFQC----------THRLLG 95

  Fly   153 RNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQNISGRIAALHIVCKNF 217
            .::|.|..::.:.|:.::          :|.....|.:::.|..|          ..|.:.||:|
Zfish    96 EHDIPLACVEQVVTVNDV----------KGKQKILGSNQKLKFNP----------TELILYCKDF 140

  Fly   218 RLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLSFAYAHREPYYSTLGASG-------- 274
            |:::|.|.:      ...:..|.:..|:..:::|....|.|.:.:....|.  |::|
Zfish   141 RIIRFRFDE------AGPESAKKVCLAIAHYSHPADPQLLFGFEYVGKRYH--GSAGERVNGVDP 197

  Fly   275 -----TSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKY---TVPPHFVIPKSCSVD 331
                 |.::...:||.||:.|.||:||:|.:          :..|.:   ::|..||:|.|.:..
Zfish   198 GGGLQTPLFDCSSDWDREIKRTGASEWRVCT----------INQGYFISPSLPEFFVVPVSLADQ 252

  Fly   332 RFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQDTKSENVMLELVRKCDAGRQLKLLQL 396
            .....:..|...|...|.:::...:||||::.:....||....:.:...:.:.......:....|
Zfish   253 DLKQYACCFYSQRIPLWCWNHPCGSALVRMSNISDPQQQRKVEQRISSAITKSHPLRSDVFKSDL 317

  Fly   397 TDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRS 461
            ...||:|||:..|..|||::|..|:.|:   .::|:|..||.:.|:.||...||:|.|....|.|
Zfish   318 DKNLPNIQDIQAALLKLRQICVIESFEE---SEEKWLSSLESSRWMEYVRTFLRHAVEVVYMLES 379

  Fly   462 -GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPA 525
             .|:.:|.|...|||.||||||.||:.|||.|::.|||:|:|||||...|.|..|..|:..:
Zfish   380 RHVSVILLEKEDRDLSCVISSLVQLMCDPHCRSLHGFQALIQKEWVMAGHRFLDRCNHLKKS--- 441

  Fly   526 GGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRL- 589
                   |.|:||:|||||||||||..|:|..||||:.|||.|.||.::|:|.||.|:...||.
Zfish   442 -------DKEESPLFLLFLDCVWQLWNQYPAAFEFTEVYLTVLGDSMWVPVFSTFLFNCPRQRAE 499

  Fly   590 --------KAV---TDSQLVLRPVWDWGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAV------- 636
                    |::   .|..|...|||||.:|||.||:..|:||||      :|..|..:
Zfish   500 HSRDFASSKSIHLGQDQALRFPPVWDWSQQFSLKDQTLFNNPLY------VGKIATCLQNGTVKT 558

  Fly   637 -AHRRSLAVGSKGAHGAAS-----GVTPS-----RNTINPQLFATASSV------PQDRY----- 679
             .||||....|....|..|     .:.|:     ||::..:|.:..|.|      |.:|:
Zfish   559 FTHRRSKKNYSSTVRGLPSLMRNGSLGPNDTLTRRNSLVLRLRSDLSQVREQPETPSERFVRDFF 623

  Fly   680 -------------LQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRL--LLSNIAKVQR 729
                         |.|:|    |.||...:.||:|...|..||  .|..:|:|  |...|..:|.
Zfish   624 SRAVDLQGLLLPQLLPSH----LSVWKLYFLRWVPEAQIPHGG--PVTAFHKLSVLTDEIEMLQN 682

  Fly   730 CL-DYQ------NFDDLPDAYYEFAGESRPNQ 754
            .| .|:      |......:...|...|.|.|
Zfish   683 QLRQYKGAAGTANTSHAEHSKMYFKATSTPQQ 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	25/113 (22%)
		PTPc	<400..587	CDD:304379	88/187 (47%)
		3-PAP	<666..732	CDD:289355	24/92 (26%)
mtmr10	XP_005168938.1	PH-GRAM_MTMR10	20..196	CDD:270154	47/247 (19%)
		PTPc	208..496	CDD:304379	114/310 (37%)
		3-PAP	566..689	CDD:289355	31/128 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590785
Domainoid	1	1.000	40	1.000	Domainoid score	I12519
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9822
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3404
OMA	1	1.010	-	-		QHG46952
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	1	1.000	-	-		FOG0003782
OrthoInspector	1	1.000	-	-		otm25183
orthoMCL	1	0.900	-	-		OOG6_107756
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5728
SonicParanoid	1	1.000	-	-		X2638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800