DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and MTMR12

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001035536.1	Gene:	MTMR12 / 54545	HGNCID:	18191	Length:	747	Species:	Homo sapiens

Alignment Length:	919	Identity:	239/919 - (26%)
Similarity:	356/919 - (38%)	Gaps:	254/919 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GGGGSGHGGAGSAGNADHHKRNTFTSYVAPLPGDLRATADTNEWCLPSDLRDVHLAKPRLLHGEQ 68
            |.|..|.||...|      .:.:|.|||.|      ....|||..:......:|     ||.|||
Human     3 GKGVVGGGGGTKA------PKPSFVSYVRP------EEIHTNEKEVTEKEVTLH-----LLPGEQ 50

  Fly    69 IVASAPAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFV-----P 128
            ::..|                 .:.|..:...|       .:...:|.|..|:||:||:     .
Human    51 LLCEA-----------------STVLKYVQEDS-------CQHGVYGRLVCTDFKIAFLGDDESA 91

  Fly   129 LHEKRNQAITAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRK 193
            |.....|.          :|..:|.|:|||:.:|.||                      |:...|
Human    92 LDNDETQF----------KNKVIGENDITLHCVDQIY----------------------GVFDEK 124

  Fly   194 KLEPFKQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYP---MRHD 255
            |...|.|.........:|  ||:.|:.:|..:      :...::.|.|.|.::.....   ::..
Human   125 KKTLFGQLKKYPEKLIIH--CKDLRVFQFCLR------YTKEEEVKRIVSGIIHHTQAPKLLKRL 181

  Fly   256 LSFAYAHREPYYS-TLGASGTSMYATKNDWARELIRC-GATEWQVVSCASVQLLQNPLQAGKYTV 318
            ..|:||......: |...:.|.|:.|..||..||.|. |..:::.||          :..| |.|
Human   182 FLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVS----------VNEG-YKV 235

  Fly   319 ----PPHFVIPKSC---SVDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQD--TKS 374
                |.:||:|...   :|.||.       ......|.:|..:.:||::::.| |..|.|  .:.
Human   236 CERLPAYFVVPTPLPEENVQRFQ-------GHGIPIWCWSCHNGSALLKMSAL-PKEQDDGILQI 292

  Fly   375 ENVMLELVRKC---DAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLL 436
            :...|:.:.|.   .....:|...|:....|:|::..||.|.::|...:...:|...|.|:..||
Human   293 QKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLL 357

  Fly   437 EKTNWLFYVSLCLRYASEASATLRS-GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSL 500
            |.::||..:..||:.|.|.:..:.: .:..:|.|.|..||||:||||.||::|||.||..|||||
Human   358 ESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSL 422

  Fly   501 VQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYL 565
            :|||||...|.|..|..|:          ...|.|:.|||||||||||||:.|.|..||||:|||
Human   423 IQKEWVMGGHCFLDRCNHL----------RQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYL 477

  Fly   566 TTLWDSCFMPIFDTFQF---------------DTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKM 615
            |.|.||.::|||.||.|               |||::.|..:|        ||||..||..|.:.
Human   478 TVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLT--------VWDWSVQFEPKAQT 534

  Fly   616 FFSNPLY-QRQRGDLG-AQAAAVAHRRSLAVGSKGAHGAASGVTPSR------------NTINPQ 666
            ...|||| ::.:.|.| .:.....|:|.|::..     ..|..:|.|            |.:..:
Human   535 LLKNPLYVEKPKLDKGQRKGMRFKHQRQLSLPL-----TQSKSSPKRGFFREETDHLIKNLLGKR 594

  Fly   667 L--FATASSVPQDRY-----------------LQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQ 712
            :  ...:|...||.:                 |.|.....:::||.|.|.||:|...|.|||  |
Human   595 ISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGG--Q 657

  Fly   713 VDLYHRLL--LSNIAKVQRCLDYQNFDDLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVDGVERR 775
            |....:||  :..:..:|..:|.::                   |..:.|..|
Human   658 VATLSKLLEMMEEVQSLQEKIDERH-------------------HSQQAPQAE------------ 691

  Fly   776 RKPTAKAATPTSGLTSVTGNLQLSTLSSFFPF-------GNPIAGDAPLQLYDILSSSSELLMET 833
                |......|           :.|||.|||       ..|:   .|...:..|....:|....
Human   692 ----APCLLRNS-----------ARLSSLFPFALLQRHSSKPV---LPTSGWKALGDEDDLAKRE 738

  Fly   834 SSFLDKSSI 842
            ..|:|...:
Human   739 DEFVDLGDV 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	28/115 (24%)
		PTPc	<400..587	CDD:304379	87/202 (43%)
		3-PAP	<666..732	CDD:289355	21/86 (24%)
MTMR12	NP_001035536.1	PH-like	26..202	CDD:327399	48/250 (19%)
		PTPc	228..496	CDD:328744	107/296 (36%)
		Interaction with MTM1. /evidence=ECO:0000269\|PubMed:12847286	449..558		50/116 (43%)
		3-PAP	563..686	CDD:315286	28/148 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155597
Domainoid	1	1.000	161	1.000	Domainoid score	I4017
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3042
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	1	1.000	-	-		FOG0003782
OrthoInspector	1	1.000	-	-		otm41897
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5728
SonicParanoid	1	1.000	-	-		X2638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890