DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and mtmr3

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_021333893.1	Gene:	mtmr3 / 393838	ZFINID:	ZDB-GENE-091204-465	Length:	1186	Species:	Danio rerio

Alignment Length:	674	Identity:	159/674 - (23%)
Similarity:	243/674 - (36%)	Gaps:	188/674 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 IDLYQENTYLGRNEITLNNIDHIYTITEL--------GRAASALQAARGMASHAGMSRRKKLEPF 198
            ::..|.|....|....|...|......||        |||..|:.|......|.         .|
Zfish     9 LECIQANQIFPRKPPVLEEEDLQVPFPELHGEFTEYVGRAEDAVIAMSSYRLHI---------KF 64

  Fly   199 KQ---QNISGRIAA---------------LHIVCKNFRLLKFAFQ-----QQDSKMFGASDQGKL 240
            |:   .|.|..::.               |||.||:.::::..|.     |:..|...|:.:...
Zfish    65 KESVVNNCSCEVSVPLQLIECVECRDMFQLHITCKDCKIVRCQFSTFEQCQEWLKRLTAAVRPPS 129

  Fly   241 IASALVRFAYPMRH----DLSFAYAHREPYYSTLGASGTSM------------YATKNDWARELI 289
            ....|..||:   |    ||   |...:..:..|...|..:            :.|:|.|
Zfish   130 RIEELFSFAF---HAWCVDL---YTGEKEQHGDLCRPGDHVMSRFHNEVERMGFDTQNAW----- 183

  Fly   290 RCGATEWQVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCSVDRFLDLSRAFCD-SRAAFWVYSYG 353
            |......:...|:|.               |..::..:...|:.|:...||.. .|....||.:.
Zfish   184 RVSEINNKYKLCSSY---------------PQLLLVPAWITDKELENVAAFRSWKRIPAVVYRHQ 233

  Fly   354 SSAALVRLAELQPAAQ----QDTKSENVMLELVRKCDA-------------------GRQL---- 391
            |:.|::.... ||...    ::...|:::..:.|.|..                   |..|
Zfish   234 STGAVIARCG-QPEVSWWGWRNADDEHLVQSIARACAVDSSSCKGVSNGSLSREYTNGADLSDVD 297

  Fly   392 -------------------KLLQLTDR------------------------------LPSIQDVL 407
                               |||.|..|                              :.:|..:.
Zfish   298 FESSMTNSSEVETLAIQPRKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIR 362

  Fly   408 RAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEAS-ATLRSGVTCVLQESN 471
            :::|.||.|||.      |.....:|..||.|.||.::||.|:.:...| |..|.....::..|:
Zfish   363 KSFQSLRFLCTQ------MPDPANWLSALESTKWLQHLSLLLKASLLVSNAVDRDHRPVLVHCSD 421

  Fly   472 GRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQ 536
            |.|....|.:||:|||||::|||:|||.||:.||:...|.|..|.||       |.|||.. :|:
Zfish   422 GWDRTPQIVALAKLLLDPYYRTIEGFQVLVETEWLDFGHKFADRCGH-------GENAEDL-NER 478

  Fly   537 SPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRP 601
            .||||.:||||.||.:|||..|||.:.:|..|....:..:|.||..::..:|    .|.::..|.
Zfish   479 CPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNSGKER----EDRRIQERT 539

  Fly   602 VWDWGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQ 666
            ...|  .........|.|.||......:   ...|.|.|:|.:.:.....::|..|||.::..|
Zfish   540 CSVW--SLLRAANRSFGNMLYSSHSETV---LHPVCHVRNLMLWTAVYLPSSSPTTPSDDSCAP- 598

  Fly   667 LFATASSVPQDRYL--QPAHRIFD 688
             :....:.|:|:.|  :|..|.||
Zfish   599 -YPAPGANPEDQPLGRRPKTRSFD 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	22/108 (20%)
		PTPc	<400..587	CDD:304379	72/187 (39%)
		3-PAP	<666..732	CDD:289355	7/25 (28%)
mtmr3	XP_021333893.1	PH-like	24..143	CDD:327399	27/130 (21%)
		Myotub-related	167..531	CDD:310891	101/402 (25%)
		FYVE_MTMR3	1094..1163	CDD:277271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840