DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Sbf2

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006507990.1	Gene:	Sbf2 / 319934	MGIID:	1921831	Length:	1904	Species:	Mus musculus

Alignment Length:	965	Identity:	200/965 - (20%)
Similarity:	304/965 - (31%)	Gaps:	381/965 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LAKPRLLHGEQIVASAPAYMYSPIDPMDSSGG--SGSTLSAISSA----------SGTPADRHHK 110
            :.:|.||.||:||......:..|....:::||  .|..|.....|          .|||.|:...
Mouse   871 ILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVG 935

  Fly   111 EAT----FGLLSVTN---------------------------FKLAF--------VPLHEKR--- 133
            |.|    |.:.|:|.                           .|:||        |.:.:|:
Mouse   936 EQTVVRSFPIASITKEKKITMQNQLQQSVQEGLQITSASFQLIKVAFDEEVSPEVVDIFKKQLMK 1000

  Fly   134 ---NQAI----------TAPLIDL---YQENT------------------------YL------- 151
               .|:|          |.|.|.|   .::||                        ||
Mouse  1001 FRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKKAGKMTIGRQYLLKKRTGT 1065

  Fly   152 ---------GRNE---ITLNNIDHIYTITELGRAASALQ------------AARGMASHAGMSRR 192
                     |.||   |::::...:.|.|.|..:..:..            ...|:.:.:|.|.|
Mouse  1066 IVEERVNRPGWNEEDDISVSDDSELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGNSSR 1130

  Fly   193 KKLEPFKQQNISGRIAA---LHIVCKNF-RLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMR 253
            .|.|.|       |:.|   |:.:|::: .||......||              |:|.|.|...|
Mouse  1131 SKPEYF-------RVTASNRLYSLCRSYPGLLVIPQAVQD--------------SSLPRVARCYR 1174

  Fly   254 HDLSFAYAHREPYYSTL--------GASGTSMYATKNDWARELIRCGATEWQVVSCASVQ----- 305
            |:.......:.....||        |.....::.::|            ..|.||.:|::
Mouse  1175 HNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQN------------SPQAVSTSSLESSSSI 1227

  Fly   306 ------------------------LLQNP---LQAG------------KYTVPPHFVI------- 324
                                    |...|   |..|            |..||.|..:
Mouse  1228 EQEKYLQALLTAVIVHQKLRGSSTLTVRPALALSPGTERRSSRMSTVLKQVVPGHLDVNPSNSFA 1292

  Fly   325 ---------------PKS----------------------CSVDRFLDLSRAFC--DSRAAFWVY 350
                           |||                      .|...|:|:.....  |..|:|...
Mouse  1293 RGVHGYRDKSFTQSNPKSSAKEPVHNQGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNS 1357

  Fly   351 SYGSSAALVRLAELQPAAQQDTKSENVMLELVRKCDAGRQLKLLQLTDRLPSIQDVLRAYQKLRR 415
            :|..:..|.|.|.|....:: ::..:..:|....|:.        :......|:.|..:::||.|
Mouse  1358 TYLQNQLLKRQAALYIFGEK-SQLRSSKVEFAFNCEF--------VPVEFHEIRQVKASFKKLMR 1413

  Fly   416 LCTPETPEKFMLQDDK---YLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQESNGRDLCC 477
            .|.|.|     :..|.   :|..|..:.|...:...::.|...|..|.:|.:..:....|.|:..
Mouse  1414 ACIPST-----IPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVWVCLEEGWDITT 1473

  Fly   478 VISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLL 542
            .::||||||.||.:|||.||::||:|||::..|.|.:|......:| .||.|        |:||.
Mouse  1474 QVTSLAQLLSDPFYRTIAGFRTLVEKEWLSFGHKFSQRSSLALNSQ-GGGFA--------PIFLQ 1529

  Fly   543 FLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGE 607
            |||||.|:..|:|.||||...||..|........|.||..|:..:||              :.|.
Mouse  1530 FLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERL--------------EHGT 1580

  Fly   608 QFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGV-----TPSRNTINPQL 667
            .|.|                                   ||...|..||     ....:|.:|..
Mouse  1581 LFDD-----------------------------------KGDKHAKKGVCIWECIDKMHTRSPIF 1610

  Fly   668 FATASSVPQDRYLQPAHRIFDLQVWDQCYYR-----------WLPIL---------DIRGGGQPQ 712
            |....|..:...|:|...:..|:.||  ||.           |:.:.         |:.||..||
Mouse  1611 FNYLYSPVEVEALKPNVNVSSLKKWD--YYTEETLSAGPSYDWMMLTPKHFPYEESDVAGGAGPQ 1673

  Fly   713 VDLYHRLLLSNIAKVQRCLDYQNFDDL----PDAYYEFAGESRPNQHK-DEKPDK 762
                          .||...:..:||:    |||......|....:|| ::.|::
Mouse  1674 --------------SQRKTVWPCYDDVTCSQPDALTRLFSEIEKLEHKLNQTPER 1714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	38/223 (17%)
		PTPc	<400..587	CDD:304379	65/189 (34%)
		3-PAP	<666..732	CDD:289355	17/85 (20%)
Sbf2	XP_006507990.1	uDENN	1..87	CDD:214824
		DENN	116..298	CDD:366936
		dDENN	352..420	CDD:129037
		SBF2	531..752	CDD:372054
		PH-GRAM_MTMR13	880..998	CDD:275416	23/117 (20%)
		PTP_DSP_cys	1136..1540	CDD:391942	99/459 (22%)
		PH_Sbf1_hMTMR5	1797..1902	CDD:269941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840