DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Mtmr2

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001101593.1	Gene:	Mtmr2 / 315422	RGDID:	1311865	Length:	643	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	187/823 - (22%)
Similarity:	305/823 - (37%)	Gaps:	262/823 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SAGNADHHKRNTFTSYVAPLPGDLRATADTNEWCLPSDLRDV-------HLAKPRLLHGEQIVAS 72
            |:.:..|.:.:..|..|:.:..|..:|:..|   ...|||.:       .:.:|.||.||.|...
  Rat    26 SSASTSHSENSVHTKSVSAISSDSISTSADN---FSPDLRVLREANKLAEMEEPALLPGENIKDM 87

  Fly    73 APAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKRNQAI 137
            |....|                  |...:|         |..|.|:|||::|.|..:.......:
  Rat    88 AKDVTY------------------ICPFTG---------AVRGTLTVTNYRLYFKSMERDPPFVL 125

  Fly   138 TAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQN 202
            .|                    ::..|..:.::|.|:|     ||..|:
  Rat   126 DA--------------------SLGVISRVEKIGGASS-----RGENSY---------------- 149

  Fly   203 ISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLS-FAYAHREPY 266
                  .|..|||:.|.|:||.:.:....       :.|...|:::|:|:.:.|. ||:.::|.:
  Rat   150 ------GLETVCKDIRNLRFAHKPEGRTR-------RSIFENLMKYAFPVSNGLPLFAFEYKEVF 201

  Fly   267 YSTLGASGTSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKY----TVPPHFVIPKS 327
                ..:|..:|....::.|:.|  ....|::.....           :|    |.|....:|.:
  Rat   202 ----PENGWKLYDPLLEYRRQGI--PNESWRITKVNE-----------RYELCDTYPALLAVPAN 249

  Fly   328 CSVDRFLDLSR-AFCDSRAAFWVYSY---GSSAALVRLAELQP---AAQQDTKSENVMLELVRKC 385
            ...:   :|.| |...||....|.|:   .|.|.:.|.:  ||   .:.:.:|.:...|:.:  .
  Rat   250 IPDE---ELKRVASFRSRGRIPVLSWIHPESQATVTRCS--QPMVGVSGKRSKEDEKYLQAI--M 307

  Fly   386 DAGRQLKLLQLTDRLPSIQDVLR-----------AYQ--------------------KLRRLCTP 419
            |:..|...:.:.|..||:..|..           |||                    ||:.:..|
  Rat   308 DSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYP 372

  Fly   420 ETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQE-SNGRDLCCVISSLA 483
            .      :::..:|..||.|:||.::.|.|..|...:..:.||.|.|:.. |:|.|....::|||
  Rat   373 N------IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLA 431

  Fly   484 QLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVW 548
            .|:||.::|||.||:.||:|||::..|.||.|:||        |:....|:::|||||.|:||||
  Rat   432 MLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGH--------GDKNHADADRSPVFLQFIDCVW 488

  Fly   549 QLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDW-GEQFSDK 612
            |:.:|||..|||.:.:|.|:.|..:..:|.||..:::.||.|.....:.|  .:|.: ..|..|
  Rat   489 QMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTV--SLWSYINSQLED- 550

  Fly   613 DKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQD 677
                |:|||:                      ||...|
  Rat   551 ----FTNPLF----------------------GSYSNH--------------------------- 562

  Fly   678 RYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLPDA 742
             .|.|...:..|::|...|.||.|.:      :||..::.|
  Rat   563 -VLYPVASMRHLELWVGYYIRWNPRM------KPQEPIHSR------------------------ 596

  Fly   743 YYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATP 785
            |.|...:....|.|.|:..:|.........||...| |:..||
  Rat   597 YKELLAKRTELQRKVEELQREISNRSTSSSERASSP-AQCVTP 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	23/110 (21%)
		PTPc	<400..587	CDD:304379	72/218 (33%)
		3-PAP	<666..732	CDD:289355	11/65 (17%)
Mtmr2	NP_001101593.1	PH-like	73..187	CDD:418428	38/194 (20%)
Mtmr2	NP_001101593.1	Myotub-related	202..528	CDD:399535	98/359 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349530
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840