DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and Mtmr12

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006232108.1	Gene:	Mtmr12 / 310155	RGDID:	1307902	Length:	748	Species:	Rattus norvegicus

Alignment Length:	865	Identity:	231/865 - (26%)
Similarity:	356/865 - (41%)	Gaps:	200/865 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GGGGSGHGGAGSAGNADHHKRNTFTSYVAPLPGDLRATADTNEWCLPSDLRDVHLAKPRLLHGEQ 68
            |.||.|.||...|      .:.:|.|||.|      ....|||    .::.:.......||.|||
  Rat     3 GKGGVGGGGGTKA------PKPSFVSYVRP------EEIHTNE----KEVTEKEEVTLHLLPGEQ 51

  Fly    69 IVASAPAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKR 133
            ::..|                 .:.|..:...|       .:....|.|..|:|:::|:   ...
  Rat    52 LLCEA-----------------STVLKYVQEDS-------CQLGICGRLVCTDFRISFL---GDE 89

  Fly   134 NQAITAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPF 198
            ..|:... .:.:.:|..:|.|:|.|:.:|.||                      |:...||...|
  Rat    90 GSAVDNG-AETHFKNKIIGVNDIPLHCVDQIY----------------------GVFDEKKKPLF 131

  Fly   199 KQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAY-PMRHDLSFAYAH 262
            .|.........:|  ||:.|:|.|..:      :...::.|.|.|.::.... |......|.:::
  Rat   132 GQLKKYPEKLVIH--CKDLRVLHFCLR------YTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSY 188

  Fly   263 REPYYSTLG--ASGTSMYATKNDWARELIRC-GATEWQVVSCASVQLLQNPLQAGKYTV----PP 320
            ....:.|..  .:.|.|:.|..||..||.|. |:.:::.||          :..| |.|    |.
  Rat   189 AAAVHGTAADPRNCTVMFDTPKDWCWELERTKGSVKYKTVS----------VNEG-YRVCDRLPA 242

  Fly   321 HFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQDT--KSENVMLELVR 383
            :||:|.....|   |:.| |.......|.:|..:.:||::::.| |..|.|:  :.:...|:.:.
  Rat   243 YFVVPTPLLED---DVKR-FQGRGIPIWCWSCHNGSALLKMSAL-PKEQDDSALQIQKSFLDGIY 302

  Fly   384 KC---DAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYV 445
            |.   .....:|...|:....|:|::..:|.|.::|...::..:|...|.|:..|||.:.||..:
  Rat   303 KTIHRPPYEMVKTEDLSSNFLSLQEIQSSYCKFKQLFLIDSSSEFWDTDVKWFSLLESSGWLDII 367

  Fly   446 SLCLRYASEASATLRS-GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALE 509
            ..||:.|.|....|.: .:..:|.|.|..||||::|||.|:::|.|.||..|||||:|||||...
  Rat   368 RRCLKRAIEIIECLEAQNMNVLLLEENASDLCCLLSSLVQVMMDAHCRTWTGFQSLIQKEWVMGG 432

  Fly   510 HPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFM 574
            |.|..|..|::.:          |.|:.|||||||||||||:.|.|..||||:||||.|.||.::
  Rat   433 HSFLDRCNHLHQS----------DKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYI 487

  Fly   575 PIFDTFQFDTQAQR----LKAVTDSQ---LVLRPVWDWGEQFSDKDKMFFSNPLY-QRQRGDLG- 630
            |||.||.|::..|:    .:...|:|   |.|..||||..||..|.:....|||| ::.:.|.|
  Rat   488 PIFSTFFFNSPHQKDTNMGRESLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDKGQ 552

  Fly   631 AQAAAVAHRRSLAVGSKGAHGAASGVTPSR--------------------NTINP---------Q 666
            .:.:...|:|.|::..     ..|..:|.|                    ..||.         :
  Rat   553 RKGSRFKHQRQLSLPL-----TQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDDLQDNSRE 612

  Fly   667 LFATASSVPQDRY--LQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQR 729
            .:....|.|.|.:  |.|.....:::||.|.|.||:|...|.|||:             :|.:.:
  Rat   613 FYDNWHSKPTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGR-------------VATMGK 664

  Fly   730 CLDYQNFDDLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVD--GVER-------------RRKPT 779
            .|             |...|.:..|.|.|......||..|.  |:.|             .::.:
  Rat   665 LL-------------EMMEEVQSLQEKIEARHHRQEAIHVQAPGLLRNSARLSSLFPFAMHQRHS 716

  Fly   780 AKAATPTSGLTSVTGNLQLS 799
            ||...||||..::.|...|:
  Rat   717 AKPVLPTSGWKALGGEDDLA 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	25/110 (23%)
		PTPc	<400..587	CDD:304379	81/187 (43%)
		3-PAP	<666..732	CDD:289355	17/67 (25%)
Mtmr12	XP_006232108.1	PH-like	26..192	CDD:302622	42/233 (18%)
		PTPc	211..497	CDD:304379	112/311 (36%)
		3-PAP	562..686	CDD:289355	30/154 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349499
Domainoid	1	1.000	162	1.000	Domainoid score	I3897
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I2994
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	1	1.000	-	-		FOG0003782
OrthoInspector	1	1.000	-	-		otm46032
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2638
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860