DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Mtmr3

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006251364.1	Gene:	Mtmr3 / 305482	RGDID:	1310972	Length:	1207	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	203/849 - (23%)
Similarity:	314/849 - (36%)	Gaps:	250/849 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 KRNQAITAPLIDLYQENT-YLGRNE---ITLNNID-HIYTITELGRAASALQAARGMASHAGMSR 191
            :.::.:..|.::|:.|:| |:||.|   |.|:|.. ||
  Rat    25 REDENLQVPFLELHGESTEYVGRAEDAIIALSNYRLHI--------------------------- 62

  Fly   192 RKKLEPFKQ----------QNISGR-IAALHIVCKNFRLLKFAF----QQQD--SKMFGA-SDQG 238
                 .||:          :::..| |..||:.||:.::::..|    |.||  .::..| ...|
  Rat    63 -----KFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFPTFEQCQDWLKRLNNAIRPPG 122

  Fly   239 KLIASALVRFAYPMRHDLSF-AYAHREPYYSTL---GASGTSMYATKNDWARELIRCG---ATEW 296
            |:  ..|..|||   |.... .||..:..:..|   |...||.:  ||    |:.|.|   ...|
  Rat   123 KI--EDLFSFAY---HAWCMEVYASEKEQHGDLCRPGEHVTSRF--KN----EVERMGFDMNNAW 176

  Fly   297 QVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCSVDRFLDLSRAFCD-SRAAFWVYSYGSSAALVR 360
            ::.:......|     .|.|  |...::| :...|:.|:....|.. .|....:|.:.|:.|::.
  Rat   177 RISNINEKYKL-----CGSY--PQELIVP-AWITDKELESVAGFRSWKRIPAVIYRHQSNGAVIA 233

  Fly   361 LAELQPAAQ----QDTKSENVMLELVRKCDAGRQ------------------------------- 390
            ... ||...    ::...|:::..:.:.|.:..|
  Rat   234 RCG-QPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRNSCRGFPNAGDLSDVEFDASLS 297

  Fly   391 ------------LKLLQLTDR------------------------------LPSIQDVLRAYQKL 413
                        .|||.|..|                              :.:|..:.|::|.|
  Rat   298 NASGTESLALQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSL 362

  Fly   414 RRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYA-SEASATLRSGVTCVLQESNGRDLCC 477
            |.|||.      |.....:|..||.|.||.::|:.|:.| ....|..|.....::..|:|.|...
  Rat   363 RLLCTQ------MPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDRDQRPVLVHCSDGWDRTP 421

  Fly   478 VISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLL 542
            .|.:||:|||||::||::|||.||:.||:...|.|..|.||       |.|::.. :|:.||||.
  Rat   422 QIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGHKFADRCGH-------GENSDDL-NERCPVFLQ 478

  Fly   543 FLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGE 607
            :||||.||.:|||..|||.:.:|..|....:..:|.||..:...:|.:..|..:..  .||
  Rat   479 WLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKQTQERTC--SVW---- 537

  Fly   608 QFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSLAVGSKGAHGAASGVTPSRNTINPQLFATAS 672
            .........|.|.||..|.   .|....|.|.|:|.:.|.......|..||:.::..|  :....
  Rat   538 SLLRAGNKAFKNLLYSSQS---EAVLYPVCHVRNLMLWSAVYLPCPSPSTPTDDSCAP--YPAPG 597

  Fly   673 SVPQDRYLQ--PAHRIFD----------------------LQVWDQCYYRWLPILDIRGGGQ--P 711
            :.|.:..|.  |..|.||                      .:.|.: :.|.|.:....|.|:  |
  Rat   598 TSPDEPPLSRLPKTRSFDNLTTTCDNMVPLASRRSSDPSLNEKWQE-HGRSLELSSFAGSGEEVP 661

  Fly   712 QVDLYH---RLL----LSNIAKVQRCLDYQNFDDLPDAYYEFAGESRPNQHKD--EKPDKEDEAE 767
            .:|...   |||    ||..|.|   .:.|..:.|.:|..|.:|...|. |::  |.|:.::||
  Rat   662 AIDSLRRPSRLLGGAELSVAAGV---AEGQMENILQEATKEESGVEEPT-HREHTEVPEVKEEA- 721

  Fly   768 FVDGVERRRKPTAK---AATPTSGLTSVTGNLQLSTLSSF-------FPFGNPIAGDAPLQLYDI 822
                      |.||   .|...||:......|..:||.|.       |..|.|...:..   :.:
  Rat   722 ----------PLAKESRTAAQGSGVLYQEPQLDDATLRSHLGPSLSSFSQGIPEHREVG---HSV 773

  Fly   823 LSSS 826
            ||||
  Rat   774 LSSS 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	22/112 (20%)
		PTPc	<400..587	CDD:304379	69/187 (37%)
		3-PAP	<666..732	CDD:289355	20/98 (20%)
Mtmr3	XP_006251364.1	PH-GRAM_MTMR3	23..116	CDD:270149	25/122 (20%)
		PTP-MTMR3	169..485	CDD:350434	80/338 (24%)
		FYVE_MTMR3	1115..1184	CDD:277271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840