DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and Mtmr4

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001099297.4	Gene:	Mtmr4 / 287607	RGDID:	1310306	Length:	1191	Species:	Rattus norvegicus

Alignment Length:	824	Identity:	182/824 - (22%)
Similarity:	293/824 - (35%)	Gaps:	254/824 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 DLYQENTYLGRNEITLNNIDHIYTITE------LGRAASALQAARGMASHAGMSRRKKLEPFKQ- 200
            ||:.....:...|    |:...:|:.:      |||||.||.|......|..........|.:.
  Rat    16 DLFPPKELVKEEE----NLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMI 76

  Fly   201 QNISGR-IAALHIVCKNFRLLKFAF------QQQDSKMFGASDQGKLIASALVRFAYPMRHDLSF 258
            .::..| :..|||.||:.::::..|      |:..|::..|:             |.|.:.:..|
  Rat    77 DSVESRDMFQLHIACKDSKVVRCHFSTFKQCQEWLSRLSRAT-------------ARPAKPEDLF 128

  Fly   259 AYAH--------REPYYSTLGASGTSMYATKNDWARELIRCG---ATEWQVVSCASVQLLQNPLQ 312
            |:|:        .|..::.|...|..:...:.   .||.|.|   ...|:|....|
  Rat   129 AFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQE---AELARMGFDLQNVWRVSHINS--------- 181

  Fly   313 AGKYTVPPHFVIPKSCSV-----DRFLDLSRAFCD-SRAAFWVYSY-GSSAALVRLAELQPAAQ- 369
              .|.:.|.:  |:...|     |:.|:...:|.. .|....||.: .:.||:.|.:  ||...
  Rat   182 --NYKLCPSY--PQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCS--QPEISW 240

  Fly   370 ---QDTKSENVMLELVRKC--DAGRQL-------------------------------------K 392
               ::...|.::..:.:.|  |.|.:.                                     |
  Rat   241 WGWRNADDEYLVTSIAKACALDPGTRASGGSLSAGTNDASEACDTDFDSSLTACSGVESTAAPQK 305

  Fly   393 LLQLTDR------------------------------LPSIQDVLRAYQKLRRLCTPETPEKFML 427
            ||.|..|                              :.:|..:..::|.||.:|:.      |.
  Rat   306 LLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQ------MP 364

  Fly   428 QDDKYLGLLEKTNWLFYVSLCLRYASEASATL-RSGVTCVLQESNGRDLCCVISSLAQLLLDPHF 491
            ....:|..||.|.||.::|:.|:.|...:.|: |.|...::..|:|.|....|.:||::||||::
  Rat   365 DPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYY 429

  Fly   492 RTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPD 556
            ||::|||.||:.:|:...|.|..|.||...|:.        .:||.||||.:||.|.|||:|||.
  Rat   430 RTLEGFQVLVESDWLDFGHKFGDRCGHQENAED--------QNEQCPVFLQWLDSVHQLLKQFPC 486

  Fly   557 EFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPL 621
            .|||.:.:|..|....:..::.||                                   ..:||.
  Rat   487 LFEFNEAFLVKLVQHTYSCLYGTF-----------------------------------LANNPC 516

  Fly   622 YQRQRGDLGAQAAAVAHRRSLAV------GSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYL 680
            .:.:|.         .::|:.:|      |:|..|...  .||.                .|..|
  Rat   517 EREKRN---------IYKRTCSVWALLRAGNKNFHNFL--YTPG----------------SDMVL 554

  Fly   681 QPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQ----RCLD----YQNFD 737
            .|...:..|.:|...|   ||.......|:..:|||    ||.:|:.|    |.||    .::.|
  Rat   555 HPVCHVRALHLWTAVY---LPASSPCTLGEENMDLY----LSPVAQSQEFSGRSLDRLPKTRSMD 612

  Fly   738 DLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVD-GVER-RRKPTAKAATPTSGLTS---VTGNLQ 797
            ||..|    ...|.|.......|:..:..:.|. .:|. ...|....|...||:.|   ..|::.
  Rat   613 DLLSA----CDTSSPLTRTSSDPNLNNHCQEVRVSLEPWHSNPEGAEAVIESGVGSPQLTVGDVG 673

  Fly   798 L-----STLSSFFPFGNPIAGDAPLQL-YDILSSSSELLMETSS 835
            |     |:...:.. ..|..|.....| |.:|::|....|:.:|
  Rat   674 LPPPLPSSQKDYLS-NKPFKGHKSCSLSYKLLNTSVSWEMKNTS 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	22/95 (23%)
		PTPc	<400..587	CDD:304379	64/187 (34%)
		3-PAP	<666..732	CDD:289355	17/69 (25%)
Mtmr4	NP_001099297.4	PH-GRAM_MTMR4	23..136	CDD:270150	28/129 (22%)
		Myotub-related	127..519	CDD:284109	103/458 (22%)
		FYVE_MTMR4	1107..1166	CDD:277272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840