DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Mtmr12

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_766546.1	Gene:	Mtmr12 / 268783	MGIID:	2443034	Length:	747	Species:	Mus musculus

Alignment Length:	906	Identity:	238/906 - (26%)
Similarity:	362/906 - (39%)	Gaps:	228/906 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GGGGSGHGGAGSAGNADHHKRNTFTSYVAP--LPGDLRATADTNEWCLPSDLRDVHLAKPRLLHG 66
            |.||.|.||...|      .:.:|.|||.|  :..|.:...:          ::|.|   .||.|
Mouse     3 GKGGVGGGGGTKA------PKPSFVSYVRPEEIHTDEKEVTE----------KEVTL---HLLPG 48

  Fly    67 EQIVASAPAYMYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHE 131
            ||::..|                 .:.|..:...|       .:...:|.|..|:||::|:...:
Mouse    49 EQLLCEA-----------------STVLKYVQEDS-------CQRGVYGRLVCTDFKISFLGDED 89

  Fly   132 KRNQAITAPLIDLYQE----NTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRR 192
            .        .:|...|    |..:|.|::.|:.:|.||                      |:...
Mouse    90 S--------ALDNGGEAQFKNKIIGVNDVPLHCVDQIY----------------------GVFDE 124

  Fly   193 KKLEPFKQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYP---MRH 254
            ||...|.|.........:|  ||:.|:|.|..:      :...::.|.|.|.::.....   ::.
Mouse   125 KKKPLFGQLKKYPEKLVIH--CKDLRVLHFCLR------YTKEEEVKRIVSGIIHHTQSPKLLKR 181

  Fly   255 DLSFAYAHREPYYSTLGASGTSMYATKNDWARELIRC-GATEWQVVSCASVQLLQNPLQAGKYTV 318
            ...|:||......:|...:.|.|:.|..||..||.|. |:.:::.||......:.:.|
Mouse   182 LFLFSYAAAVHGTATDSRNCTVMFDTPKDWCWELERTKGSVKYRTVSVNEGYRVSDRL------- 239

  Fly   319 PPHFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQD--TKSENVMLEL 381
            |.:||:|.....|   |: |.|.......|.:|..:.:||::::.| |..|.|  .:.:...|:.
Mouse   240 PAYFVVPTPLPED---DV-RRFQGHGIPIWCWSCHNGSALLKMSAL-PKEQDDGALQVQKSFLDG 299

  Fly   382 VRKC---DAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLF 443
            :.|.   .....:|...|:....|:|::..||.|.::|...:...:|...|.|:..|||.::||.
Mouse   300 IYKTIHRPPYEMVKTEDLSSNFLSLQEIQSAYCKFKQLFLIDNSSEFWDTDIKWFSLLESSSWLD 364

  Fly   444 YVSLCLRYASEASATLRS-GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVA 507
            .:..||:.|.|.:..|.: .|..:|.|.|..||||::|||.|:::|.|.||..|||||:|||||.
Mouse   365 IIRRCLKKAIEITECLEAQNVNVLLLEENASDLCCLLSSLVQVMMDAHCRTRTGFQSLIQKEWVM 429

  Fly   508 LEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSC 572
            ..|.|..|..|::.:          |.|:.|:|||||||||||:.|:|..||||:||||.|.||.
Mouse   430 GGHSFLDRCNHLHQS----------DKEEVPIFLLFLDCVWQLVHQYPPAFEFTETYLTVLSDSL 484

  Fly   573 FMPIFDTFQF------DTQAQRLKAVTDSQ-LVLRPVWDWGEQFSDKDKMFFSNPLY-QRQRGDL 629
            ::|||.||.|      ||...|......|: |.|..||||..||..|.:....|||| ::.:.|.
Mouse   485 YIPIFSTFFFNSPHQKDTNMGRENLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDR 549

  Fly   630 GAQ-AAAVAHRRSLAVGSKGAHGAASGVTPSR------------NTINPQLFATASSVPQDRYLQ 681
            |.| .:...|:|.|::..     ..|..:|.|            |.:..::....:|...   ||
Mouse   550 GQQKGSRFKHQRQLSLPL-----TQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDD---LQ 606

  Fly   682 PAHRIF----------------------DLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNI 724
            .:.|.|                      :::||.|.|.||:|...|.|||:             :
Mouse   607 DSSREFYDSWHSKPTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGR-------------V 658

  Fly   725 AKVQRCLDYQNFDDLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGL 789
            |.:.:.|             |...|.:..|.|.|             ....|:....|..|
Mouse   659 ATMGKLL-------------EMMEEVQSLQEKIE-------------ARHHRQEAVHAEAP---- 693

  Fly   790 TSVTGNLQLST-LSSFFPF-------GNPIAGDAPLQLYDILSSSSELLMETSSFLDKSSI 842
                |.|:.|. |||.|||       ..|:   .|...:..|....:|......|:|...:
Mouse   694 ----GLLRNSVRLSSLFPFALLQRHSAKPV---LPTSGWKALGGEDDLAKREDEFVDLGDV 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	26/114 (23%)
		PTPc	<400..587	CDD:304379	84/193 (44%)
		3-PAP	<666..732	CDD:289355	17/87 (20%)
Mtmr12	NP_766546.1	PH-like	26..204	CDD:302622	46/252 (18%)
		PTPc	210..496	CDD:304379	111/307 (36%)
		Interaction with MTM1. /evidence=ECO:0000250	449..558		51/108 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..575		7/31 (23%)
		3-PAP	561..685	CDD:289355	29/170 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846042
Domainoid	1	1.000	163	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I3031
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	1	1.000	-	-		FOG0003782
OrthoInspector	1	1.000	-	-		otm43944
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5728
SonicParanoid	1	1.000	-	-		X2638
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.890