DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and Mtmr10

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_766330.2	Gene:	Mtmr10 / 233315	MGIID:	2142292	Length:	771	Species:	Mus musculus

Alignment Length:	894	Identity:	237/894 - (26%)
Similarity:	372/894 - (41%)	Gaps:	216/894 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RNTFTSYVAPLPGDLRATADTNEWCLPSDLRDVHLAKPRLLHGEQIVASAPAYMYSPIDPMDSSG 88
            |.:|.||:.|       .|.|::..  |....:...:|.||.||.:|
Mouse     8 RPSFRSYLLP-------PAQTDDKI--SSEPKIKKLEPVLLPGEIVV------------------ 45

  Fly    89 GSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFV---PLHEKRNQAITAPLIDLYQENTY 150
               :.::.:.....|...::.   .:|.|..:|||::|:   |:          ||...:..|..
Mouse    46 ---NEVNFVRKCIATDTSQYD---LWGKLICSNFKISFITDDPM----------PLQKFHYRNLL 94

  Fly   151 LGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQNISGRIAALHIVCK 215
            ||.:::.|..|:.|.|:.:..|....|          |.:::.|..|          ..|.|.||
Mouse    95 LGEHDVPLTCIEQIVTVNDHKRKQKVL----------GPNQKLKFNP----------TELIIYCK 139

  Fly   216 NFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYPMRHDLSFAYAHREPYY------------- 267
            :||:::|.|.:      ...:..|.:..|:..::.|....|.||:.:....|
Mouse   140 DFRIVRFRFDE------SGPESAKKVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSANKVNGVSSG 198

  Fly   268 -----STLGASG---TSMYATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKYTVPPHFVI 324
                 |..|::|   |.::.|.:||.||..|.||:.|:|.|.....::...|       |.:||:
Mouse   199 GGGVWSGAGSTGSQRTPLFETYSDWDRETKRTGASGWRVCSINEGYMISTCL-------PEYFVV 256

  Fly   325 PKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQDTKSENVMLELVRKCDAGR 389
            |.|.:.......|.:|...|..||.:|:.:.:||||:|.::.|.||....:.:...:.:......
Mouse   257 PSSLADQDLKIFSHSFVGRRMPFWCWSHSNGSALVRMALIKDALQQRKIDQRICNAITKSHPQRS 321

  Fly   390 QLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASE 454
            .:....|...||:||::..|:.||::||..|..|:   .::|:|..||.|.||.||...|::::|
Mouse   322 DVYKSDLDKALPNIQEIQAAFVKLKQLCVNEPFEE---TEEKWLSSLESTRWLEYVRAFLKHSAE 383

  Fly   455 ASATLRS-GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGH 518
            ....|.| .::.||||..||||.|:::||.|:::||:||||.|||||:|||||...:.|..|..|
Mouse   384 LVYILESQRLSVVLQEEEGRDLSCLVASLIQVMMDPYFRTITGFQSLIQKEWVMAGYQFLDRCNH 448

  Fly   519 VYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFD 583
            :..::           ::||:||||||..||||:|:|..|||::|||..|.||..:.:|.||.|:
Mouse   449 LKRSE-----------KESPLFLLFLDTTWQLLEQYPAAFEFSETYLAVLCDSTRISLFGTFLFN 502

  Fly   584 TQAQRLKAVT------------DSQLVLRPVWDWGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAV 636
            :..||:|..|            :..|....||||..||:.||:..|.||.|      :|.....|
Mouse   503 SPHQRVKQSTEFAISKNIQLGDEKGLKFPSVWDWALQFTAKDRTLFHNPFY------IGKSTPCV 561

  Fly   637 AH--RRSLAVGSKGAHGAASG--------------VTPSRNTI------NPQLFATASSVPQDRY 679
            .:  |:|.....|.......|              :.|.||::      :|.....:.....::|
Mouse   562 QNGSRKSFKRTKKSYSSTLRGMPSCLKNGIITDQDLLPRRNSLVLKLKPDPPQHTDSQHSGAEQY 626

  Fly   680 L-----QPA--HRIF-------DLQVWDQCYYRWLPILDIRGGGQPQVDLYHR--LLLSNIAKVQ 728
            .     :||  |.|.       .:::|..||:||:|...|..||  .:..:|:  ||...:..:.
Mouse   627 FKEWFSRPANLHGIILPRLSGTHIKLWKLCYFRWVPEAQINLGG--SIMAFHKLSLLADEVDMLS 689

  Fly   729 RCLDYQNFDDLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGLTSVT 793
            |.|.......|...|.|.                 |::..   ..|...|.....||
Mouse   690 RMLRQHRSGPLEACYAEL-----------------DQSRM---YFRATGPHDTLGTP-------- 726

  Fly   794 GNLQLSTLSSFFPFGNPIAGDAPLQLYDILSSSSELLMETSSFLDKSSI 842
                 ..|||.||| :|:..         |...|.|....|.||..:.|
Mouse   727 -----EFLSSSFPF-SPVGN---------LCRRSILGTPLSKFLSGAKI 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	28/113 (25%)
		PTPc	<400..587	CDD:304379	82/187 (44%)
		3-PAP	<666..732	CDD:289355	18/81 (22%)
Mtmr10	NP_766330.2	PH-GRAM_MTMR10	21..193	CDD:270154	45/233 (19%)
		PTPc	222..503	CDD:304379	113/301 (38%)
		3-PAP	574..701	CDD:289355	25/128 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846052
Domainoid	1	1.000	163	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9822
Inparanoid	1	1.050	266	1.000	Inparanoid score	I3031
Isobase	1	0.950	-	0	Normalized mean entropy	S5636
OMA	1	1.010	-	-		QHG46952
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	1	1.000	-	-		FOG0003782
OrthoInspector	1	1.000	-	-		otm43944
orthoMCL	1	0.900	-	-		OOG6_107756
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5728
SonicParanoid	1	1.000	-	-		X2638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750