DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and Mtmr4

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006532446.1	Gene:	Mtmr4 / 170749	MGIID:	2180699	Length:	1204	Species:	Mus musculus

Alignment Length:	826	Identity:	180/826 - (21%)
Similarity:	293/826 - (35%)	Gaps:	258/826 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 DLYQENTYLGRNEITLNNIDHIYTITE------LGRAASALQAARGMASHAGMSRRKKLEPFKQ- 200
            ||:.....:...|    |:...:|:.:      ||||..||.|......|..........|.:.
Mouse    30 DLFPPKELVKEEE----NLQVPFTVLQGEGVEFLGRATDALIAISNYRLHIKFKDSVINVPLRMI 90

  Fly   201 QNISGR-IAALHIVCKNFRLLKFAF------QQQDSKMFGASDQGKLIASALVRFAYPMRHDLSF 258
            .::..| :..|||.||:.::::..|      |:..|::..|:             |.|.:.:..|
Mouse    91 DSVESRDMFQLHIACKDSKVVRCHFSTFKQCQEWLSRLSRAT-------------ARPAKPEDLF 142

  Fly   259 AYAH--------REPYYSTLGASGTSMYATKNDWARELIRCG---ATEWQVVSCASVQLLQNPLQ 312
            |:|:        .|..::.|...|..:...:.   .||.|.|   ...|:|....|
Mouse   143 AFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQE---AELARMGFDLQNVWRVSHINS--------- 195

  Fly   313 AGKYTVPPHFVIPKSCSV-----DRFLDLSRAFCD-SRAAFWVYSY-GSSAALVRLAELQPAAQ- 369
              .|.:.|.:  |:...|     |:.|:...:|.. .|....||.: .:.||:.|.:  ||...
Mouse   196 --NYKLCPSY--PQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCS--QPEISW 254

  Fly   370 ---QDTKSENVMLELVRKC--DAGRQL-------------------------------------K 392
               ::...|.::..:.:.|  |.|.:.                                     |
Mouse   255 WGWRNADDEYLVTSIAKACALDPGTRASGGSLSTGTNDASEACDTDFDSSLTACSGVESTAAPQK 319

  Fly   393 LLQLTDR------------------------------LPSIQDVLRAYQKLRRLCTPETPEKFML 427
            ||.|..|                              :.:|..:..::|.||.:|:.      |.
Mouse   320 LLILDARSYTAAVANRAKGGGCECEEYYPNCEVLFMGMANIHAIRNSFQYLRAVCSQ------MP 378

  Fly   428 QDDKYLGLLEKTNWLFYVSLCLRYASEASATL-RSGVTCVLQESNGRDLCCVISSLAQLLLDPHF 491
            ....:|..||.|.||.::|:.|:.|...:.|: |.|...::..|:|.|....|.:||::||||::
Mouse   379 DPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYY 443

  Fly   492 RTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPD 556
            ||::|||.||:.:|:...|.|..|.||...|:.        .:||.||||.:||.|.|||:|||.
Mouse   444 RTLEGFQVLVESDWLDFGHKFGDRCGHQENAED--------QNEQCPVFLQWLDSVHQLLKQFPC 500

  Fly   557 EFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPL 621
            .|||.:.:|..|....:..::.||                                   ..:||.
Mouse   501 LFEFNEAFLVKLVQHTYSCLYGTF-----------------------------------LANNPC 530

  Fly   622 YQRQRGDLGAQAAAVAHRRSLAV------GSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYL 680
            .:.:|.         .::|:.:|      |:|..|..              |:...|.|    .|
Mouse   531 EREKRN---------IYKRTCSVWALLRAGNKNFHNF--------------LYTPGSDV----VL 568

  Fly   681 QPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQ----RCLD----YQNFD 737
            .|...:..|.:|...|   ||.......|:..:|||    ||.:|:.|    |.||    .::.|
Mouse   569 HPVCHVRALHLWTAVY---LPASSPCTLGEENMDLY----LSPVAQSQEFSGRSLDRLPKTRSMD 626

  Fly   738 DLPDAYYEFAGESRPNQHKDEKPDKEDEAEFVDG-VERRRKPTAKAATPTSGLTSVTGNLQLSTL 801
            ||..|    ...|.|.......|:..:.::.|.| :|........|.|.   :.|..|:.||:..
Mouse   627 DLLSA----CDTSSPLTRTSSDPNLNNHSQEVRGSLEPWHSSPEGAETV---IDSGVGSPQLTVG 684

  Fly   802 SSFFP-----------FGNPIAGDAPLQL-YDILSSSSELLMETSS 835
            ....|           ...|..|.....| |.:|::|....|::::
Mouse   685 EMGLPPPLPSSQKEYLSNKPFKGHKSCSLSYKLLNTSVSWEMKSNT 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	21/95 (22%)
		PTPc	<400..587	CDD:304379	64/187 (34%)
		3-PAP	<666..732	CDD:289355	19/69 (28%)
Mtmr4	XP_006532446.1	PH-GRAM_MTMR4	37..150	CDD:270150	27/129 (21%)
		PTP-MTMR4	186..493	CDD:350435	78/335 (23%)
		Atrophin-1	743..>863	CDD:367360
		FYVE_MTMR4	1120..1179	CDD:277272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840