DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14411 and mtmr11

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001313370.1	Gene:	mtmr11 / 101882209	ZFINID:	ZDB-GENE-130530-726	Length:	814	Species:	Danio rerio

Alignment Length:	671	Identity:	182/671 - (27%)
Similarity:	279/671 - (41%)	Gaps:	158/671 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 GLLSVTNFKLAFVPLHEKRNQAITAPLIDLYQENTYLGRNEITLNNIDHIYTITELGRAASALQA 179
            |.|..|:|::||||...::......|::        ||.:::.|.:|:.:..:
Zfish    68 GTLFCTHFRVAFVPQDSQKPDDNADPVL--------LGDHDVALASIEKVVAV------------ 112

  Fly   180 ARGMASHAGMSRRKKLEPFKQQNISGRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASA 244
                    |.||.|.:.|......:.....|:  |::.|:|.|.|.:     .....|...|...
Zfish   113 --------GPSRTKLVTPTCSLKFTPEELVLY--CRDLRVLCFLFDR-----LTPDTQAVEITYT 162

  Fly   245 LVRFAYPMRHD--LSFAYA--------------HREPYYSTLGASGTSMYATKNDWARELIRCGA 293
            :.:...|::..  |||..|              .|:|..:.|..|        ..|.:||.|.||
Zfish   163 IAKTYQPLKPGTILSFQNAALGSIEMKQFLSNRRRDPSMNWLECS--------LGWEQELERTGA 219

  Fly   294 TEWQVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCSVDRFLD--LSRAFC---DSRAAFWVYSYG 353
            :.|:|.|.       |.......::|...|:|:     |.||  |.:.|.   :.|...|.:.:.
Zfish   220 SGWRVSSV-------NDRFEMSTSLPRFNVVPQ-----RVLDTELKKTFAHFNEGRIPRWCWRHP 272

  Fly   354 SSAALVRLAELQPAAQQDTKSENVMLELVRKCDAGRQL-KLLQLTDRLPSIQDVLRAYQKLRRLC 417
            ..:.|:|:|..|.....: |.:...||||  ...|:|| .::.|.:.:||..|:..|:.:||.||
Zfish   273 RGSDLLRMASFQNNIYHE-KDDIRNLELV--LFGGQQLCVIVDLGEEMPSPADIQLAHTRLRTLC 334

  Fly   418 TPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSG-VTCVLQESNGRDLCCVISS 481
            ..:......:.|||:|..||.|.||.|...|||.|:|....||:| :|.||||...||:.||:.|
Zfish   335 LGDISSSVSVPDDKWLSTLESTRWLDYTRCCLRKAAEVCCLLRAGHMTVVLQEPEDRDMNCVVCS 399

  Fly   482 LAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDC 546
            |.|::.|||.||:.|||.||||||:...|.|..|:.:...:          |.|::|||||||||
Zfish   400 LVQVMCDPHCRTVAGFQGLVQKEWITAGHKFLSRINYHRES----------DKEEAPVFLLFLDC 454

  Fly   547 VWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLV---------LR-- 600
            ||||..|:|..|:.|:.||..|.||..:|:|.:|..::|.:|.:.   ||.:         ||
Zfish   455 VWQLWAQYPARFQLTEDYLLALHDSVHLPLFSSFLANSQRERCRR---SQHLPQSYTPVNGLRDV 516

  Fly   601 --------------PVWDWGEQFSDKDKMFFSNPLYQRQ------RGDLGAQAAAVAHR----RS 641
                          |||||..|:|.:.:..|:.|:.|..      .|:|........|.    .|
Zfish   517 PMSVPEEPVDPPFPPVWDWALQYSSQRRARFTQPISQPTCPPPVLNGNLNTNLERSWHNDGLPGS 581

  Fly   642 LAVGSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYLQPAHRIFD------------------ 688
            :.:.|:......|.:.|.|::.:...:.:....|....|....|:..
Zfish   582 VFLLSRSTFSHPSNLLPWRSSNSGSYWKSHRRAPSSESLSGLERLIRACSLSEPSENNTILHDPY 646

  Fly   689 -----------LQVWDQCYYR 698
                       ::||..||.|
Zfish   647 EPLLPLLLGPCVRVWRSCYLR 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	23/109 (21%)
		PTPc	<400..587	CDD:304379	83/187 (44%)
		3-PAP	<666..732	CDD:289355	8/62 (13%)
mtmr11	NP_001313370.1	PH-GRAM_MTMR11	41..162	CDD:275433	26/128 (20%)
		PTPc	210..495	CDD:304379	116/309 (38%)
		3-PAP	578..703	CDD:289355	13/90 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590804
Domainoid	1	1.000	40	1.000	Domainoid score	I12519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25183
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.000