DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14411 and mtmr12

DIOPT Version :9

Sequence 1:	NP_001162756.1	Gene:	CG14411 / 32408	FlyBaseID:	FBgn0030582	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_012823020.2	Gene:	mtmr12 / 100495643	XenbaseID:	XB-GENE-6051019	Length:	748	Species:	Xenopus tropicalis

Alignment Length:	847	Identity:	227/847 - (26%)
Similarity:	349/847 - (41%)	Gaps:	191/847 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GAGSAGNADHHKRNTFTSYVAPLPGDLRATADTNEWCLPSDLRDVHLAKPRLLHGEQIVASAPAY 76
            |.|:.|.|...|:.:|.||:.|...|::....:.|          .:....||.||.::..|
Frog     3 GLGTGGAAKSPKQPSFVSYLTPEEIDVKEKEPSAE----------KVDNVPLLPGEFVLCEA--- 54

  Fly    77 MYSPIDPMDSSGGSGSTLSAISSASGTPADRHHKEATFGLLSVTNFKLAFVPLHEKRNQAITAPL 141
                           :|:...:...|:      :...:|.|..|||::.|:.         ..|.
Frog    55 ---------------NTVLKCTQDEGS------QRGVYGRLICTNFRITFLG---------DEPP 89

  Fly   142 IDLYQE--NTYLGRNEITLNNIDHIYTITELGRAASALQAARGMASHAGMSRRKKLEPFKQQNIS 204
            .|...|  |...|.|:|||..:|.:|                      |:...||......|.:.
Frog    90 DDTIPEFKNKIFGENDITLQCVDQLY----------------------GVYDDKKKAILSGQGLK 132

  Fly   205 GRIAALHIVCKNFRLLKFAFQQQDSKMFGASDQGKLIASALVRFAYP---MRHDLSFAYAHREPY 266
            .....|.:.||:||:..|...      :...::.|.|.|.::.....   ::....|:||...|.
Frog   133 KYPERLIVYCKDFRVFHFCLS------YTKQEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVPR 191

  Fly   267 YS-TLGASGTSMYATKNDWARELIRC-GATEWQVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCS 329
            |. |.....|.|:.|..||..||.|. |...::|::......:...|       |.:||:|.|..
Frog   192 YKVTSFMEKTLMFETVKDWMAELERTKGNLHYKVLTANEGYKVSERL-------PQYFVVPMSLP 249

  Fly   330 VDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQDT--KSENVMLELVRKC---DAGR 389
            .|...|    |.......|.:|..:.:||:::|.| |....|.  :.:...|:.|.|.   ....
Frog   250 EDTLTD----FQGRGVPIWCWSCPNGSALLKMASL-PKDVDDVALQHQRTFLDRVEKTLHRPPYE 309

  Fly   390 QLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASE 454
            ::::..||..|||:.:|..||.:.::|...|....|...|.|:...|:.:||:..:..|||.|.|
Frog   310 EVRIEDLTASLPSLSEVQVAYCRFKQLFLIENSTDFWDTDLKWFSSLDTSNWMEIIRQCLRKAVE 374

  Fly   455 ASATLRS-GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGH 518
            ....|.: .:..||:|....|.||:||||.|:::||:.||..|||||||||||...|.|..|..|
Frog   375 VIEYLETHKINVVLKEDTASDFCCIISSLVQIMMDPYCRTKIGFQSLVQKEWVMGGHCFLDRCNH 439

  Fly   519 VYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFD 583
            :..           :..::|||||||||||||:||:|..||||:||||.|.||..:|||.||.|:
Frog   440 LRK-----------NENEAPVFLLFLDCVWQLVQQYPLAFEFTETYLTVLSDSINIPIFSTFFFN 493

  Fly   584 TQAQR-LKAVTDSQ-------LVLRPVWDWGEQFSDKDKMFFSNPLY--QRQRGDLGAQAAAVAH 638
            :..|: ..:|.:.:       |....||||..||..|...|.:||||  :.:...:..:||...|
Frog   494 SPWQKDTHSVVEGRQGKQGESLRFYTVWDWSVQFEPKAISFLNNPLYVEKAKLEKISRKAARTKH 558

  Fly   639 RRSLAV--------GSKGAHGAASGVTPSRNTI----NPQLFATASSVPQD--RYLQPAHR---- 685
            :|.|::        ..:|.....:|  |...|:    ..:|.:....||.:  .:.:..||
Frog   559 QRQLSLPLTQSKTPNKRGFFKDETG--PFIKTLLGKRISKLISALDDVPNNGWAFYESWHRKPVD 621

  Fly   686 ----IF------DLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDYQNFDDLP 740
                |.      |:::|.|...||:|...:.|||             |:|.:|:.|:..  |:|.
Frog   622 FHGLILPHLEGPDIRIWAQRLLRWIPEAQVLGGG-------------NVATMQKILEVT--DELK 671

  Fly   741 DAYYEFAGESRPNQHKDEKPDKEDEAEFVDGVERRRKPTAKAATPTSGLTSVTGNLQLSTLSSFF 805
            ....:.  |:.|.  ..:.|.||:|.:     .||:|...:                    ||.:
Frog   672 CLKKKL--ENNPT--LPQYPSKENETD-----ARRKKSVRR--------------------SSLY 707

  Fly   806 PF 807
            ||
Frog   708 PF 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14411	NP_001162756.1	PH-like	<114..225	CDD:302622	27/112 (24%)
		PTPc	<400..587	CDD:304379	83/187 (44%)
		3-PAP	<666..732	CDD:289355	18/81 (22%)
mtmr12	XP_012823020.2	PH-GRAM_MTMR12	25..201	CDD:275418	45/246 (18%)
		PTP-MTMR12	259..460	CDD:350442	74/212 (35%)
		3-PAP	560..678	CDD:403693	27/136 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2874
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279113at33208
OrthoFinder	1	1.000	-	-		FOG0003782
OrthoInspector	1	1.000	-	-		otm49116
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5728
SonicParanoid	1	1.000	-	-		X2638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100