DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14408 and SH3BP5

DIOPT Version :9

Sequence 1:	NP_001285247.1	Gene:	CG14408 / 32407	FlyBaseID:	FBgn0030581	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_004835.2	Gene:	SH3BP5 / 9467	HGNCID:	10827	Length:	455	Species:	Homo sapiens

Alignment Length:	447	Identity:	131/447 - (29%)
Similarity:	203/447 - (45%)	Gaps:	95/447 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESNTPVDPRVQVELEKLNSATDNINRYEVELDEAKCEFKRLLAESVVRIKAAAHKLGNSIDAAKP 68
            |....||||:|.||||||.:||:|||.|.||::|:.:|:.:|.|:.|::.....|:|.:::.:||
Human    36 EEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKP 100

  Fly    69 YYESRIYAAQLAKETQLAAANHEKAKSIHAAAKEMVYLAEQGL--GEKSTLDTACQEMLSHAASK 131
            |:|:|..|.|...|.|.|..:.::|..:..||||.:.||||.|  .:|...|:|.||||:||..:
Human   101 YWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQR 165

  Fly   132 VNQSQLEVTDTRNAL--KMCQLKLEVANNRVGKLQGQLKQALRASRLQLKRNLLLLRYFSIMHAL 194
            |.::  |.|.||:.|  |....:...|..|:.:|:.:||:|:..|:
Human   166 VMEA--EQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSK------------------- 209

  Fly   195 YCTLCSPYYETRANYNGLLKAQKTRVNELEAKVSAAKLTYNEALKNLEQISEDIHRQRQQ----- 254
                  ||:|.:|.|...|:..|..|::|:||::.||..|..||||||.||::||.:|:.
Human   210 ------PYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEIHERRRSSAMGP 268

  Fly   255 RNNLLNYEAMLRQV----------DAVDTLTAGLERSSCGTAANRQDLEAKAAAEEQKHVEAEAE 309
            |...:..|.....|          ||:...:...|..||....:..|.|.::.:.......:.:|
Human   269 RGCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSE 333

  Fly   310 EEEEEYLRMPE------RLGHHECPHLLTDFEAVLTFP---------------------QKLAGG 347
                    ||:      |.|..:.|..::..|..:.||                     .:..|.
Human   334 --------MPDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRSECSGASSPECEVERGDRAEGA 390

  Fly   348 MHKSASTGAAADGEAGLGPLGLHAPYEVKSGSGSLASGSASVSTSAGGAPADNDIEQ 404
            .:|   |...|:...||           .|.|||..|..:..|||..|...:|.::|
Human   391 ENK---TSDKANNNRGL-----------SSSSGSGGSSKSQSSTSPEGQALENRMKQ 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14408	NP_001285247.1	SH3BP5	7..255	CDD:283045	94/256 (37%)
SH3BP5	NP_004835.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		17/26 (65%)
		Sufficient for interaction with RAB11A and for guanine nucleotide exchange activity. /evidence=ECO:0000269\|PubMed:30217979	31..265		95/255 (37%)
		SH3BP5	41..269	CDD:310118	94/254 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..293		4/33 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..345		8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..435		17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S5575
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258813at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19423
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.870