DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14408 and Sh3bp5

DIOPT Version :9

Sequence 1:	NP_001285247.1	Gene:	CG14408 / 32407	FlyBaseID:	FBgn0030581	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_036024.2	Gene:	Sh3bp5 / 24056	MGIID:	1344391	Length:	458	Species:	Mus musculus

Alignment Length:	469	Identity:	129/469 - (27%)
Similarity:	220/469 - (46%)	Gaps:	93/469 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESNTPVDPRVQVELEKLNSATDNINRYEVELDEAKCEFKRLLAESVVRIKAAAHKLGNSIDAAKP 68
            |....||||:|.||||||.:||:|||.|.||::|:.:|:.:|.|:.|::...|.|:|.:::.:||
Mouse    39 EEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKP 103

  Fly    69 YYESRIYAAQLAKETQLAAANHEKAKSIHAAAKEMVYLAEQGL--GEKSTLDTACQEMLSHAASK 131
            |:|:|..|.|...|.|.|..:.::|..:..||||.:.||||.|  .:|...|:|.||||:||..:
Mouse   104 YWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQR 168

  Fly   132 VNQSQLEVTDTRNAL--KMCQLKLEVANNRVGKLQGQLKQALRASRLQLKRNLLLLRYFSIMHAL 194
            |.::  |.|.||:.|  |....:...|..|:.:|:.:||:|:..|:
Mouse   169 VMEA--EQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSK------------------- 212

  Fly   195 YCTLCSPYYETRANYNGLLKAQKTRVNELEAKVSAAKLTYNEALKNLEQISEDIHRQRQQRNNLL 259
                  ||:|.:|.|...|:..|..|::|:||::.||..|..|||:||:||::||.:|  |:|.:
Mouse   213 ------PYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERR--RSNAM 269

  Fly   260 -----------------NYEAMLRQVDAVDTLTAGLERSSCGTAANRQDLEAKAAAEEQKHVEAE 307
                             |......:.||:...:...|..:|....:..|.|.::.:.......:.
Mouse   270 GPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSP 334

  Fly   308 AEEEEEEYLRMPE------RLGHHECPHLLTDFEAVLTFPQKLAGGMHKSASTGAAAD------G 360
            :|        ||:      |.|..:.|..::..|..:.||  :.|  .:|..:||::.      |
Mouse   335 SE--------MPDQFPAVARPGSLDLPSPVSLSEFGMMFP--ILG--PRSECSGASSPECEVERG 387

  Fly   361 EAGLGPLGLHAPYEVKSGSGSLASGSASVSTSAGGAPADNDIEQWTEIRLSHSDSTSSSYSNQSL 425
            :...|         .::.....|:.:..:.::.||:....          |.|.::..|.:.::.
Mouse   388 DRAEG---------AENKMSDKANNNRVLGSTNGGSGRSR----------SQSSTSLESQALETR 433

  Fly   426 LEQQGLDSTGGMSG 439
            ::|..|..:.|..|
Mouse   434 MKQLSLQCSKGRDG 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14408	NP_001285247.1	SH3BP5	7..255	CDD:283045	94/251 (37%)
Sh3bp5	NP_036024.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		18/29 (62%)
		Sufficient for interaction with RAB11A and for guanine nucleotide exchange activity. /evidence=ECO:0000250\|UniProtKB:O60239	33..268		96/257 (37%)
		SH3BP5	44..270	CDD:283045	96/254 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..348		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..429		11/75 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S5575
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258813at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19423
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.870